Jana Sticht's research while affiliated with Freie Universität Berlin and other places

... Next is 2,6-dipicolinic acid (DPA, 3) 27 , which demonstrates potency in micromolar against three major MBLs. In addition, the ongoing efforts in this eld were emphasized by the recently reported indole-2-carboxylates (4) 28 , quinoline-2-carboxylates (5) 29 and sulfonamides (6, 7) 30,31 as promising MBLIs. ...

... Our study revealed that HLA DR + + monocyte AC may be the key immune cell trait mediating the causal relationship between the level of Phosphatidylcholine (16:1_18:1) and female infertility. HLA-DR is an MHC-II class molecule expressed on B lymphocytes, monocytes, macrophages, activated T-lymphocytes, activated NK-lymphocytes, and human progenitor cells [22]. Research has shown that HLA-DR expression is linked to both successful IVF implantations, and the mechanism underlying this relationship may be the down-regulation of HLA-DRs, which re ects the absence of antigen-presenting cells in the endometrium and causes infertility [23,24]. ...

... This tryptophan residue and other aromatic positions conserved on the surface of the β-sheet are involved in establishing interactions, converting this surface into the binding platform for peptide recognition 51,52 . Several studies have analyzed the binding selectivity of WW domains, classifying them in different groups depending on the type of peptide motif recognized 53 ; in most cases, WW domains show some promiscuity to bind proline-rich sequences, and recently it has been proposed that this ambiguity can be reduced by the combination of two WW domains in tandem 54,55 . For the PRPF40A WW domains, only the binding of the first one has been extensively characterized, and a short proline-rich motif (PPLP) was identified with an affinity in the high micromolar range 56 . ...

... LMP2 attenuates ischaemia/hypoxia-induced blood-brain barrier injury through Wnt/β-catenin signalling activation 51 . Transporter associated with antigen processing (TAP) binding protein (TAPBP) encodes tapasin, a key MHC-I pathway component 52,53 , that mediates inflammatory injury via CD8 + T-cell infiltration 52,54 . A novel partial MHC II structure, DRmQ, promotes ischaemic stroke neuroprotection by inhibiting neuroantigen-specific T cells and blocking cytotoxic monocytes/macrophages 55 . ...

... 5 HLA alleles have been extensively studied in several disorders, 6 and particularly associated with autoimmmune and infectious disease susceptibility, resistance, severity and particular clinical outcomes. For instance, the HLA-DQB1*03:02 is associated with type 1 diabetes development, 7 HLA-C*12:02 and HLA-DQB1*06:01 with severe acute hepatitis protection, 8 and HLA-B*27 strongly with ankylosing spondylitis. 9 Generally, the mechanism underlying these associations is related to differential antigen presentation. ...

... As of March 2024, the IPD-IMGT/HLA Database has catalogued a cumulative count of 38,975 HLA alleles, with 9877 alleles described for the HLA-B gene. 1 These molecules serve as fundamental elements in the discrimination between self and non-self and are instrumental in the presentation of antigens to T cells, thus instigating immune responses. 2 In this report the identification of the novel HLA-B*38:01:01:18 allele, is described. It was observed in a 29-year-old Greek female, who was typed for HLA class I and II by NGS technology as volunteer bone marrow donor, during routine typing for HLA class I (HLA-A, -B and -C) and class II (HLA-DRB1, -DQB1 and -DPB1), developed at the Immunology and Histocompatibility Department of Evangelismos General Hospital in Athens. ...

... The sorting signals that target UcPS cargos for secretion are not fully defined. For type I UcPS, cargos appear to contain specific protein sequences that facilitate membrane binding and translocation (8), whereas two consensus targeting sequences were identified for some type III UcPS cargos (9). By contrast, for lysosome-mediated type III UcPS, cargos first enter the lumen of lysosomes via the endosomal sorting complexes required for transport-dependent multivesicular body formation, which uses ubiquitin as a sorting signal (10). ...

... They are preceded by five SH3 domains (Fig. 4A). ITSN1L (hereafter just ITSN1) is constitutively active due to a five amino acid insertion in the SH3A domain 71,72 . ITSN1 SH3A binds synaptojanin1, SH3B binds endophilin. ...

... FBP21 and other B-specific proteins are displaced again during the BRR2-dependent conversion of the B complex to the B act complex 4,27 . FBP21 stably interacts with the Sec63 module of the BRR2 CC and inhibits the BRR2mediated U4/U6 di-snRNA unwinding 28,29 . Two additional, largely intrinsically disordered proteins (IDPs), NTR2 and SNU66, interact with the BRR2 CC in yeast [30][31][32] . ...

... The data of the selected proteins are gathered in Supplementary information (Hemmings et al. 1984;McCubbin et al. 1985;Lynch et al. 1987;Donaldson and Capone 1992;Uversky et al. 1999Uversky et al. , 2002aUversky et al. , 2002bWilkins et al. 1999;Guez et al. 2000;Campbell et al. 2000;Bouvier and Stafford 2000;Adkins and Lumb 2002;Danielsson et al. 2002Danielsson et al. , 2008Karlin et al. 2002;Denning et al. 2002Denning et al. , 2003Permyakov et al. 2003;Zeev-Ben-Mordehai et al. 2003;Tcherkasskaya et al. 2003;Longhi et al. 2003;Mayor et al. 2003;Chong et al. 2004;Sánchez-Puig et al. 2005a, b;Yiu et al. 2006;Goldgur et al. 2007;Geething and Spudich 2007;Magidovich et al. 2007;Khaymina et al. 2007;Gall et al. 2007;Yi et al. 2007;Lowry et al. 2008;Zhang et al. 2008;Paleologou et al. 2008;Kapłon et al. 2008;Krishnan et al. 2008;Paz et al. 2008;Soragni et al. 2008;Haaning et al. 2008;Sivakolundu et al. 2008;Baker 2009;Neira et al. 2009;Habchi et al. 2010;Choi et al. 2011;Perez et al. 2014;Langridge et al. 2014;Yarawsky et al. 2017;Poznar et al. 2017;Wollenhaupt et al. 2018;Więch et al. 2019;Chatterjee and Pollard 2019). ...