Jacob M. Hilzinger's research while affiliated with University of California, Berkeley and other places
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Publications (11)
Spirulina is the common name for the edible, non-heterocystous, filamentous cyanobacterium Arthrospira platensis that is grown industrially as a food supplement, animal feedstock, and pigment source. Although there are many applications for engineering this organism, until recently no genetic tools or reproducible transformation methods have been p...
Space bioprocess engineering (SBE) is an emerging multi-disciplinary field to design, realize, and manage biologically-driven technologies specifically with the goal of supporting life on long term space missions. SBE considers synthetic biology and bioprocess engineering under the extreme constraints of the conditions of space. A coherent strategy...
Electromicrobial production (EMP) processes based on CO 2 -fixing microbes that directly accept electrons from a cathode have received significant attention in the past decade. However, fundamental questions about the performance limits and viability of this strategy remain unanswered. Here, we sought to determine what would be necessary for such a...
Electromicrobial production (EMP) systems can store renewable energy and CO2 in many-carbon molecules inaccessible to abiotic electrochemistry. Here, we develop a multiphysics model to investigate the fundamental and practical limits of EMP enabled by direct electron uptake. We also identify potential electroautotrophic organisms and metabolic engi...
Reinvigorated public interest in human space exploration has led to the need to address the science and engineering challenges described by NASA's Space Technology Grand Challenges (STGCs) for expanding the human presence in space. Here we define Space Bioprocess Engineering (SBE) as a multi-disciplinary approach to design, realize, and manage a bi...
Reinvigorated public interest in human space exploration has led to the need to address the science and engineering challenges described by NASA's Space Technology Grand Challenges (STGCs) for expanding the human presence in space. Here we define Space Bioprocess Engineering (SBE) as a multi-disciplinary approach to design, realize, and manage a bi...
A crewed mission to and from Mars may include an exciting array of enabling biotechnologies that leverage inherent mass, power, and volume advantages over traditional abiotic approaches. In this perspective, we articulate the scientific and engineering goals and constraints, along with example systems, that guide the design of a surface biomanufact...
Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical systems. Space agencies can no longer reduce the majority of the human health and performance risks through crew...
A crewed mission to and from Mars may include an exciting array of enabling biotechnologies that leverage inherent mass, power, and volume advantages over traditional abiotic approaches. In this perspective, we articulate the scientific and engineering goals and constraints, along with example systems, that guide the design of a surface biomanufact...
Microbial electrosynthesis (MES) systems can store renewable energy and CO 2 in many-carbon molecules inaccessible to abiotic electrochemistry. Here, we develop a multiphysics model to investigate the fundamental and practical limits of MES enabled by direct electron uptake and we identify organisms in which this biotechnological CO 2 -fixation str...
Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical system. Space agencies can no longer buy down the majority of human system risk through the crew member selection...
Citations
... Electroporation involves applying a high-intensity electrical field to generate pores in the cell membrane, allowing DNA entry. So far, electroporation has been established for only a few cyanobacterial species, including A. platensis, Anabaena sp., Synechococcus sp., Synechocystis sp., F. diplosiphon and the nitrogen-fixing Plectonema boryanum [68,127]. Optimal voltage and pulse duration for high-efficiency transformation are species-specific [129]. ...
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... ESA, for example, has explicitly recognized the 'socio-economic impact of space activities'. We argue that meaningful societal advantages and benefits are achievable through equitable distribution gains engendered specifically by space bioprocess engineering (SBE) 10 technologies. ...
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... However, each process should be designed considering its own requirements and specifications. Gaseous substrates such as CO 2 , methane or syngas can be used for the production of renewable chemicals, as well as in more futuristic applications like CO 2 fixation in a Martian atmosphere [83]. However, mass transfer limitations in gas fermentations remain as an obstacle to solve, although several strategies are proposed [84]. ...
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... By establishing human communities on other celestial bodies, we can preserve our cultural legacy and collective knowledge while also ensuring the survival of the human species. Numerous real-world applications of space exploration and colonization can be found in disciplines including environmental sustainability, materials science, and medicine [1,2].Future generations may be motivated to seek scientific and technological advancements as a result of space travel and colonization. Space exploration has the power to advance society and open up new avenues for growth and discovery by pushing the boundaries of human knowledge and capacity.For a number of reasons, including scientific research, technological development, and the possibility of human settlement of other planets, humans are thinking of visiting Mars [3]. ...
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... In situ resource utilization (ISRU) is being seen as an essential concept to extend capabilities without penalizing or sacrificing redundancy, as well as to break the supply chain from Earth, which is pivotal to sustaining human exploration of deep space (Hall, 2017). For ISRU, biotechnology holds some of the most promising approaches (Menezes et al., 2015;Rothschild, 2016;Verseux et al., 2016;Nangle et al., 2020;Berliner et al., 2021a). Fundamentally, the ability of biology to fix inorganic carbon can generate carriers of energy and substrates for biotechnology in the form of biomass, which can be converted into more reduced carbon feedstocks, e.g., methane (Averesch, 2021). ...
... Light-independent, lithoautotrophy can fix carbon by relying on chemically provided reducing power. On Mars, this could either directly be electricity through microbial electrosynthesis in bio-electrochemical systems (Moscoviz et al., 2016;Abel et al., 2020;Chen et al., 2020a), or indirectly by means of hydrogen or (organoautotrophically) formate, both of which can also be generated electrochemically (Kracke et al., 2020;Abel and Clark, 2021). Use of other electron donors like, e.g., sulphide, sulphur and iron (II) is theoretically possible, but technically less feasible (crustal materials from Mars are in principle able to support lithotrophic growth (Milojevic et al., 2021), but mining and purifying these in quantities that could support biotechnological processes is likely not viable). ...
