J.M. Murphy's scientific contributions
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Publications (2)
The JAK–STAT pathway is the central intracellular signal transduction cascade initiated by ligand binding to numerous growth factor and cytokine receptors, and since its discovery two decades ago it has been the subject of extensive investigation. The pathway is negatively regulated by the SOCS family proteins, which restrict the extent of the cyto...
The JAK–STAT pathway is the central intracellular signal transduction cascade initiated by ligand binding to numerous growth factor and cytokine receptors, and since its discovery two decades ago it has been the subject of extensive investigation. The pathway is negatively regulated by the SOCS family proteins, which restrict the extent of the cyto...
Citations
... SOCS3 SOCS3 contributes to the STAT3-JAK-SOCS3 pathway, which is usually activated by pro-inflammatory cytokines and switched off by SOCS3 (Murphy et al., 2016) and plays a prominent role in adipose regulation and leptin signaling (Scarpace et al., 2001;Gurzov et al., S100A9 and SOCS3 as biomarkers 2016). Emerging evidence indicates that JAK-STAT3 has a protective role in AMI by elevating the sensitivity of ischemic preconditioning (Yasukawa et al., 2012;Nohara et al., 2021), and the blockage of SOCS3 shows an effect on prevention of myocardial damage and ventricular reconstruction (Eid et al., 2018). ...
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