J Kragstrup's research while affiliated with Aarhus University Hospital and other places
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Publications (26)
Cross-sectional osteon size was measured in undecalcified stained sections of iliac crest bone specimens from normal individuals (n = 68) and from patients with spinal osteoporosis (n = 27), primary hyperparathyroidism (n = 23), epilepsia (receiving chronic anti-convulsant therapy) (n = 11), acromegaly (n = 18), and hypothyroidism (n = 12). In each...
The objective of this study was to describe induced heterotopic bone formation in the rat using stereologic methods and to optimize the sampling for toxicologic studies. Bone formation was induced by implants of demineralized bone powder in 24 male Wistar rats. The ossicles formed were removed after 14, 16, 17, 18, and 20 days. From each ossicle, s...
Ectopic bone formation was induced in 14 rats receiving 100 ppm fluoride in drinking water and in 14 control animals. Sections from ossicles removed after 14 and 20 days were sampled for stereological analysis. Bone volume density and bone volume were reduced in experimental animals on day 14 (p less than 0.05). This difference was no longer presen...
This paper describes the reconstruction of the remodelling cycle in normal iliac crest cortical bone from static and dynamic variables after double labelling with tetracycline in 10 young normal individuals. The average duration of the resorptive period was 27 days during which the average rate of resorption was 4.7 microns/day. The final resorptio...
The purpose of this histomorphometric study of iliac bone biopsies from 10 postmenopausal osteoporotic patients was to describe
the effects of sodium fluoride (combined with calcium and vitamin D) on remodeling in cortical bone after 6 months and after
5 years of tretment. Biopsies had been fixed in absolute methanol, embedded undecalcified in meth...
The purpose of the experiment was to assess the effects of fluoride (F-) on the remodeling process of cortical bone. Sixteen pigs, eight experimental animals receiving a supplement of 2 mg F-/kg b.w. and eight controls, were studied in individual sites from age 8 to 14 months. At slaughter samples of cortical bone were obtained from the right femur...
The purpose of this study was to describe cortical bone remodeling by means of a new stereologic model, which is based on isotropic uniform (IUR) histological sections and two fluorochrome tissue time markers (tetracycline and calcein) given with a 15-day interval. From each of five pigs two samples of cortical bone were sawed out from the middle p...
The aim of the investigation was to measure the effect of fluoride on vertebral trabecular bone compressive strength and to correlate this with fluoride-induced changes in bone density. This correlation would express changes in the quality of bone during fluoride treatment. Pigs were used in the experiment because their trabecular bone structure an...
The conventional stereologic procedure for estimating bone surface densities in iliac crest biopsies gives biased estimates because bone substructure is anisotropic and the sectioning of the biopsies is intended to be parallel to the cylindrical axis of the iliac crest biopsy. It has recently been shown that random anisotropic sections with an iden...
The aim of this study was to test whether dental fluorosis can be produced by administration of chronic doses of fluoride during only the post-secretory stage of enamel mineralization. Eight control and eight experimental pigs matched by weight and litter were fed a low-fluoride diet (less than 0.05 mg F-/kg b.w. daily) from weaning to slaughter at...
The purpose of this study was to determine whether total serum calcium, parathyroid gland structure, and/or levels of parathyroid hormone, 1,25 and 24,25 DHCC, are altered in pigs with dental and skeletal fluorosis. Eight experimental animals receiving 2 mg F-/kg b.w. per day from age 8-14 months were compared with eight controls. Concentrations of...
The present study was undertaken to estimate bio-availability and biological half-life of fluoride and accumulation of fluoride in bone in the domestic pig. Eight animals receiving 2 mg F ⁻ /kg b.w. per day from age 8 to 14 months were compared with eight controls.
Plasma fluoride concentrations just prior to the daily oral dose were measured at re...
The experiment aimed at describing effects of fluoride on structure and remodeling of vertebral trabecular bone in pigs. Eight animals receiving a supplement of 2 mg F-/kg b.w. per day from age eight to 14 mo were compared with eight controls. Plasma fluoride increased from 0.7 +/- 0.1 microM/1 to 12.7 +/- 2.0 microM/1 in pigs receiving fluoride. A...
With the aim of investigating whether patients with otosclerosis suffer from a generalized bone disorder, a histomorphometric analysis of trabecular bone from the iliac crest was performed. Iliac crest biopsies from 10 patients with otosclerosis and 20 normal controls were obtained after tetracycline double labelling and examined by histomorphometr...
Radiographs of the left forelimb were obtained after slaughter in 16 14-month-old pigs. From age 8-14 months, eight pigs in the experimental group received 2 mg F-/kg body weight per day. Bone maturity in F-animals was the same as in controls. Cortical thickness was increased by 10 per cent in the fluorotic animals (p less than 0.01) and their plas...
The three-dimensional (3-D) thickness of lamellae in normal trabecular bone was estimated by means of a stereologic transformation of the apparent width measured on 7 mm stained sections of undecalcified iliac bone from 65 nondiseased individuals aged 16--90 years. The average 3-D thickness of double lamellae (one bright and one dark) was 6.4 mm wi...
The thickness of the bone walls formed at completed remodeling sites was estimated by morphometry in iliac trabecular bone from 85 normal individuals (48 women and 37 men) aged 18-90 years. The mean three-dimensional (3-D) wall thickness was 59.4 +/- 5.9 micron. No sex difference was observed. The wall thickness decreased with age: Thickness (micro...
The anatomy of the remodeling sites in bone is only partly reflected by random histologic sections. This study is aimed at reconstructing the three-dimensional morphology of the osteons in human trabecular bone from serial sections of decalcified tissue. The osteons resembled broad bands, which were made up of parallel lamellae, bounded on one side...
Cross-sectional osteon size was measured in undecalcified stained sections of iliac crest bone specimens from normal individuals (n = 68) and from patients with spinal osteoporosis (n = 27), primary hyperparathyroidism (n = 23), epilepsia (receiving chronic anti-convulsant therapy) (n = 11), acromegaly (n = 18), and hypothyroidism (n = 12). In each...
The wall thickness of completed remodeling sites in trabecular bone was estimated in 25 normal individuals and 5 patients with arthrosis of the knee, using 7 micron sections of undecalcified iliac crest bone. A systematic sampling procedure which gives a surface referent estimate of the thickness was applied. The efficiency of the sampling design w...
The calcification rate and the completed wall thickness of remodeling sites in trabecular bone were estimated in undecalcified sections of tetracycline double-labeled iliac crest bone biopsies from 20 epileptic patients aged 19 to 50 years receiving long-term combined anticonvulsant therapy and 20 age- and sex-matched normal individuals. Surface di...
The mean wall thickness of iliac trabecular bone packets was determined in undecalcified iliac crest bone specimens from 14 hypothyroid patients, 14 hyperthyroid patients and 28 age- and sex-matched normal controls. Calcification rate and fractional resorption, formation and labeled surfaces in trabecular bone from the patients were measured by con...
Citations
... Since then, researchers from different countries have developed new techniques and have introduced concepts that allowed the development of bone histomorphometry, considered the key tool to study bone metabolism, remodelling and structure. [3][4][5][6] ...
... Numerous histomorphometric studies of cortical osteons have provided insights into cortical bone remodelling during health, ageing, and disease [7,[9][10][11][12][13][14][15][16][17][18]. Most have focused on the mean dimensions of the osteons as a measure of the mean size of the resorption cavity (osteon area, osteon diameter), the mean magnitude of infilling (mean wall thickness), and the overall remodelling balance between these two activities (pore area, pore diameter). ...
... Our results are on the line with earlier human as well as animal studies where F treatment increased BMD [39][40][41]. On the other hand, a significant decrease in BMD of cortical bone (forearm radius) [39,41] suggests that F has anabolic and catabolic effects on trabecular and cortical bone respectively [42] and induces cortical porosity [43,44]. In phase I, higher bone turnover was observed, which in turn has a significant increase in BMD due to the presence of F. In phase II, on Ca supplementations to groups 4X and 4Y, BMD showed significant recovery irrespective of F intake. ...
... Bone remodeling consists of resorption, reversal, and formation phases, which take approximately 6 months (Agerbaek et al., 1991). Therefore, bone turnover markers, biomarkers reflecting bone formation and bone resorption, are more effective than BMD in assessing bone responses to exercise interventions in a shorter duration (<6 months). ...
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... Many reports have confirmed that fluoride stimulates bone formation (18)(19)(20). On the other hand, almost no confirmed or reliable relationships have been observed between fluoride exposure and the prevalence of bone fractures (21)(22)(23)(24)(25). It is generally accepted that the hydroxyapatite structure is a prototype for the structure of bone mineral, and fluoride ions substitute for the hydroxy ions giving rise to partially fluoridated hydroxyapatite or fluoroapatite. ...
... The rate of bone regeneration depends on various factors such as the defect size, the location of the defect, and condition of the subject. One previous study showed that the bone regeneration rate of the human mandible is 1.0-1.5 lm/day [77], while another study estimated that the remodeling rate of human cortical bone is only about 3%/year [78]. On comparing the in-vivo results obtained herein, we observed that the biodegradation rate of the proposed porous Mg scaffold was still faster than the bone regeneration rates reported previously. ...
... Most of the included studies reported the use of minipigs, particularly Göttingen minipigs, on average 19-20 months old. In general, minipigs are reported to be more morphologically similar to humans in terms of skeletal features than lager farm breeds and have a more similar rate of mandibular bone regeneration (1.2-1.5 mm/day) to humans (1.0-1.5 mm/day) than do dogs (1.5-2.0 mm/day) [58,59]. Moreover, several biological features of minipig alveolar bone, such as bone volume, density, etc. are reported to be similar to those of humans [19]. ...
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... Although a few previous studies have successfully identified the PTGs in domestic pigs and minipigs (e.g. Andersen et al., 1986;Soshin et al., 2010) we have recognized the need for a detailed guideline for the fast dissection of porcine PTGs to ensure sample integrity for downstream expression and histology analyses. Klute (1959) provided a guideline for the fresh tissue dissection of PTGs in domestic pigs, but the respective instructions were only intended and useful for the dissection of carcasses (sagittally bisected bodies) during commercial slaughter. ...
... This study utilized the manufacturing approach, which consists in prepolymer infiltration onto the ceramic scaffold and in situ crosslinking. Ultimately, the ultimate bone compression strength lies within the MPa region [18][19][20] depending on bone type and measuring technique and it has to be taken under consideration while discussing the boundary load bearing capabilities of the material. ...
... Accordingly, many studies have used pigs as model organisms in various fields of dental research. These studies either focused on the normal process of enamel mineralization Gil-Bona et al., 2023;Kirkham et al., 1988;Robinson et al., 1987Robinson et al., , 1988Sova et al., 2018) or on the effects of undernutrition, exposure to excess levels of drugs or toxicants, or other kinds of developmental stress on dental hard tissue formation (Dobney et al., 2007;Dobney & Ervynck, 2000;Ervynck & Dobney, 1999, 2002Giunta et al., 1993;Kierdorf et al., 2004;McCance et al., 1961;Richards et al., 1986;Skinner & Byra, 2019;Tonge & McCance, 1973). ...
