J. K. Kwakye's scientific contributions
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Publications (6)
To improve the efficiency of medicines quality monitoring in developing countries by reducing the limitations of lack of regular access to chemical reference standards(CRS) and corresponding financial burden, a new approach of using readily available compounds, physico-chemically related to the active pharmaceutical ingredient (API) as surrogate re...
Purpose: Compounds chemically related to analyte as surrogate reference standards in quantitative HPLC and the impact of internal standard on such applications have been investigated. Method: A simple reversed-phase isocratic HPLC method with UV detection was developed and validated. The solutes were paracetamol (principal analyte), caffeine (inter...
Purpose: The mechanics of ion-pair complex formation between 1-cyclopropyl- 6-fluoro- 4-oxo- 7-
piperazin- 1-yl- quinoline- 3-carboxylic acid monohydrochloride (CPF) and 4,4'-(1,1-dioxido-3 H-2,1-
benzoxathiole-3,3-diyl)bis(2,6-dibromophenol) (BPB) and its application in Ghana for quality control of some
medicinal agents have been examined. Method:...
The bioequivalence of two generic paracetamol products and an innovator, Tylenol Forte, was studied in six healthy male subjects in a single-dose randomized cross-over fashion using the amount of unchanged paracetamol excreted in urine over 24 hours. The two generic products were coded as Paracetamol CoA and Paracetamol CoB. Preliminary sample iden...
High Performance Liquid Chromatography has been used to evolve an analytical procedure for the evaluation of the content of paracetamol in the bulk, dosage forms and in urine, a body fluid. Separation and resolution have been achieved with a combination of methanol and 2.5% acetic acid (15:85) on a reversed-phase column at ambient temperature. Elut...
Citations
... In an attempt to overcome the limitation of lack of regular access to CRS in drug analyses and to strengthen cost effective management of the quality of pharmaceuticals in Sub-Saharan Africa, we had in a preliminary study [5] examined the use of compounds chemically related to target analytes as surrogate reference standards in quantitative HPLC. In this context, a suitable surrogate reference standard should be physicochemically similar to the analyte of interest. ...
... [4] PCM classified as nonsteroidal antiinflammatory drug (NSAID) analgesics, is often used as an analgesic, joint aches, middle ear aches, a painkiller effect on headaches, toothaches, neuralgia, aches stem from cold, flue and lumbago. [5] Numerous analytical methods were reported for the determination of this drugs in pharmaceuticals such as SP-FT-Raman [6] , HPLC [7][8][9][10] , Electromagnetic [11] , Spectrophotometric [12][13][14][15] , Ion selective electrode [16] , Thermogravimetric analysis (TGA) [17] and Voltammetry. [18] Aim of this work is to use the ease and accurate spectrophotometric method for the determine the drugs content in tablet samples from different pharmaceutical companies available in Iraqi pharmaceutical market, to give information about these products, which may or may not comply with the requirements of the standard method or other official methods. ...
