J. Dirks's research while affiliated with University of Pretoria and other places
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Publications (2)
This study was undertaken to assess whether gamma-linolenic acid (GLA) in the form of evening primrose oil (EPO) could affect rat serum cytokines, interferon-gamma (IFN-gamma), monocyte chemotactic protein-1 (MCP-1) and tumour necrosis factor-alpha (TNF-alpha). The following diets were administered: control, glucan, Freund's adjuvant and glucan plu...
The aim of this study was to determine whether evening primrose oil (EPO), as substrate for pro-inflammatory compounds such as prostaglandins and leukotrienes, affects the immune response during an elicited delayed hypersensitivity reaction in healthy individuals. In a placebo-controlled, randomized single blind parallel study, blood was collected...
Citations
... An interesting example of Oenothera, a genus of about 125 species of annual, biennial and perennial herbaceous flowering plants which has attracted attention within the past few years, is the Evening Primrose (Oenothera biennis). The seeds, containing -linolenic acid (GLA), have been used to produce edible oil which exhibits anti-diabetic, antitumor, and antipremenstrual properties200201202203204205206 . The major product of oilseed cold-pressing or extraction is the remains of seeds and meal, being a source of natural polyphenol antioxidants scavenging hydrogen peroxide and oxygen-derived free radicals [201,207208209. ...
... Regarding O. biennis, the administration of the seed oil (namely, evening primrose oil) in animal models enhanced PGE1 synthesis in peritoneal macrophages, decreased PGE2 amounts in granulocytes, and suppressed the natural killer (NK) cell activity and lymphocyte proliferation; moreover, it decreased the serum levels of interferon γ (IFN-γ) and MCP-1, while stimulating TNF-α [187][188][189][190][191]. Furthermore, anti-inflammatory effects have been found to be involved in the immunomodulation by evening primrose oil [160]. ...
