Isaac O. Afara's research while affiliated with The University of Queensland and other places

... Previously, CRISPR-Cas9 has been used to modify GSL glycans on leukocyte cells [81], and it might be useful for regenerating cartilage [82]. The multi-omics of cartilage from a spatio-temporal perspective is currently of vital interest [83,84]. On the other hand, spatial and temporal analysis of glycome expression patterns on tissues is limited to N-glycans due to technical difficulties [85][86][87][88]. ...

... It is known that articular cartilage zonal architecture influences its optical properties [9], [10]. This study investigates the parametric characterization of light propagation in articular cartilage. ...

... Of note, NIR spectroscopy has gained increasing recognition in human medical research [21], particularly for screening pathological kidney tissues and conditions associated with fibrotic and steatotic liver diseases [22][23][24]. The versatility of this technique has also been proven in veterinary medicine and meat inspection, where NIR and ultraviolet-visible (UV) spectroscopy, often integrated within hyperspectral imaging systems, have been successfully employed to differentiate normal from septicemic poultry carcasses, discriminate among different poultry myopathies [25][26][27][28], identify milk spot livers [29], and discern between healthy and pathological sheep lung tissues [30]. ...

... The notion of a testing platform that is reagent-free and requires minimal sample preparation is incredibly attractive, especially in the context of achieving a cost-effective yet efficient analysis of numerous samples or patients in routine clinical practices [3]. Data fusion, also known as data blocking, combines two or more systems biology datasets from different "omics" modalities to generate greater organism insights and can be exploited to provide an even more integrated approach [4]. Biospectroscopy approaches employ spectrochemical technologies (Table 1) primarily associated with mid-infrared (MIR) or Raman platforms [5], although near-infrared (NIR) can also be included [4]. ...

... Here the probe was pressed against tissue samples with tip window diameter 2 mm (total ø 3.25 mm) to take an average of 10 co-added scans (30 ms exposure) from the centre of each sample. Samples were chosen from biopsy plugs 4 or 8 mm in diameter, or measurements taken from intact tissue with 3.25 mm separation [57][58][59]. ...