Inês Duarte's research while affiliated with Centro Hospitalar Lisboa Norte and other places
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Publications (26)
Introduction:
In chronic kidney disease (CKD) patients, the risk of kidney replacement therapy (KRT) is highly variable. In 2011, Tangri et al. developed the kidney failure risk equations (KFRE) to predict the 2 and 5-year probability of requiring kidney replacement therapy (KRT). The KFRE is an easily calculated 4-variable equation which has been...
BACKGROUND AND AIMS
In chronic kidney disease (CKD) patients, the risk of kidney replacement therapy (KRT) is highly variable. In 2011, Tangri et al. developed the kidney failure risk equations (KFRE) to predict the 2- and 5-year probability of requiring kidney replacement therapy (KRT). The KFRE is an easily calculated 4-variable equation that has...
Introduction: In chronic kidney disease (CKD) patients, the risk of kidney replacement therapy (KRT) is highly variable. In 2011, Tangri et al developed the kidney failure risk equations (KFRE) to predict the 2 and 5 year probability of requiring kidney replacement therapy (KRT). The KFRE is an easily calculated 4-variable equation which has been e...
Introduction:
Acute kidney injury (AKI) has been described in Coronavirus Disease 2019 (COVID-19) patients and is considered a marker of disease severity and a negative prognostic factor for survival. In this study, the authors aimed to study the impact of transient and persistent acute kidney injury (pAKI) on in-hospital mortality in COVID-19 pat...
Introduction:
The use of Rituximab (RTX) in glomerular diseases (GD) has increased in the past years, although it is still only used in a small fraction of patients.
Methods:
A single center retrospective study of adult patients with membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS), lupus nephritis (LN), and vasculitis trea...
Introduction:
COVID-19 is currently a global health issue and an important cause of mortality. Chronic kidney disease (CKD) is one of the risk factors for infection, morbidity and mortality by SARS-CoV-2. In our study, we aimed to evaluate the clinical presentation and outcomes of CKD patients with COVID-19, as well as identify predictors of morta...
Background:
The incidence of AKI in coronavirus disease 2019 (COVID-19) patients is variable and has been associated with worse prognosis. A significant number of patients develop persistent kidney damage defined as Acute Kidney Disease (AKD). There is a lack of evidence on the real impact of AKD on COVID-19 patients. We aim to identify risk facto...
Corona Virus Disease-19 (COVID-19) recently emerged as a global pandemic. Advanced age is the most important risk factor for increased virus susceptibility and worse outcomes. Many older adults are currently treated with renin–angiotensin–aldosterone system (RAAS) inhibitors and there is concern that these medications might increase the risk of mor...
Background and Aims
Glomerular diseases (GD) account for about 20% of chronic kidney disease causes. They are a heterogeneous group of diseases and current treatment is still inadequate. Rituximab (RTX) is a chimeric antibody which binds specifically to the B-cell surface antigen CD20 and has been applied in the treatment of different GD. The autho...
Introduction:
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a multisystemic disease. Despite the improvement in mortality rate since the introduction of immunosuppression, long-term prognosis is still uncertain not only because of the disease activity but also due to treatment associated adverse effects. The neutrophil-to-lym...
Fournier gangrene is a progressive necrotizing infection of the external genitalia or perineum that constitutes a urologic emergency. Incidence of Fournier gangrene is rising because of population aging, increasing comorbidities, and widespread use of immunosuppressive therapy, including immunosuppressive regimens used in kidney transplants. This i...
Atypical hemolytic uremic syndrome (aHUS) is a rare disease. It results from the dysregulation of the alternative complement pathway on the cell surface which causes endothelial damage. Increasing evidence links, these abnormalities to mutations in genes of complement regulators or with autoantibodies against complement factors. These mutations hav...
Introduction
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a multisystemic disease. Despite the improvement in mortality rate since the introduction of immunosuppression, long-term prognosis is still uncertain not only because of the disease activity but also due to treatment associated adverse effects. The neutrophil-to-lymph...
Background and Aims
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a multisystemic disease. Despite the improvement in mortality rate since the introduction of immunosuppression, long-term prognosis is still uncertain not only because of the disease activity but also due to treatment associated adverse effects. The neutrophil-t...
Objective
To determine risk factors for in-hospital mortality in elderly patients with acute kidney injury (AKI) requiring dialysis.IntroductionAKI requiring dialysis is frequent in elderly and is associated with an increased intra-hospital mortality. With the growing number of older individuals among hospitalized patients with AKI demands a thorou...
Background and Aims
Cyclophosphamide (CYC), associated with corticosteroids has been considered the mainstay of treatment for severe antineutrophil cytoplasmic antibody−associated vasculitis (AAV) for decades. This protocol is effective in 70-90% of patients resulting in drastic improvement in both renal and patient survival. Nevertheless, cyclopho...
Introduction:
Acute kidney injury (AKI) is a frequent diagnosis in surgical patients which has a detrimental effect on short-term and long-term outcomes. The purpose of this study was to evaluate the incidence and predictive factors of transient and persistent postoperative AKI in patients submitted to major abdominal surgery and to characterize t...
Malignant ascites is a rare first manifestation of gastric carcinoma and is usually associated with symptoms which include early satiety, abdominal pain and deteriorating clinical state. The authors describe the case of a male patient presenting with malignant ascites of rapid onset which was the sole presentation of gastric cancer, highlighting th...
Mineral bone disorder is a common feature of chronic kidney disease. Lion face syndrome is rare complication of severe hyperparathyroidism in end-stage renal disease patients, which has been less commonly reported due to dialysis and medical treatment advances in the last decade. The early recognition of the characteristic facial deformity is cruci...
Anemia is a common finding after kidney transplantation (KT). Herein, we present a 34-year-old man who received a deceased-donor KT in 2017. Induction immunosuppression therapy consisted of thymoglobulin, tacrolimus (TAC) and methylprednisolone; the maintenance therapy included mycophenolate (MMF) 500 + 500 mg, TAC 4 + 4 mg and prednisolone (PD) 5...
Citations
... The most widely used prediction model is the Kidney Failure Risk Equation (KFRE) [9]. It has been validated in different populations [10][11][12][13] and is easily calculable in daily clinical practice. It is applied to patients with CKD G3 + . ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281181594604-1692095128264_Q64/Bernardo-Marques-Da-Silva.jpg)
... Duarte I et al. 3 present 19 patients with glomerular disease treated with RTX, retrospectively analyzed and with two different protocols of posology. Four of the 19 patients had FSGS, one of whom was considered steroid-resistant, whereas two patients both of whom were not steroid-resistant responded to the use of RTX. ...
Reference: Use of rituximab in glomerulopathies
... As complicações causadas pela LRA envolvem encefalopatia, pericardite, lesão renal crônica e insuficiência respiratória, sendo um preditor para a mortalidade, principalmente quando associada à Covid-19 (9) . Diante da alta incidência e morbimortalidade da LRA, o enfermeiro atua como elemento fundamental na prevenção da doença, ao identificar os sintomas de forma precoce e assertiva, bem como no cuidado ao paciente complexo, ao construir um plano (10) . ...
... These findings are consistent with a study conducted in a reference hospital in Lisbon, Portugal, which reported a mortality rate of 26.2% among CKD patients diagnosed with COVID-19, with a majority of them being considerably older. However, there was no differentiation by gender in that study (Branco et al., 2021). This differs from a study conducted in Paris, where 65.9% of dialysis patients with COVID-19 were male (Tortonese et al., 2020). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281252043916-1718466577898_Q64/Claudia-Costa-59.jpg)
... presentaban HAS, mientras que la mortalidad asociada al desarrollo de LRA fue del 67.7% de la población que desarrolló LRA (192) 18 . Si bien se sabe que la hipertensión no tiene un incremento en la mortalidad en los pacientes con infección por SARS-CoV-2, la presencia de LRA representa un incremento importante en la mortalidad de los pacientes 19 . Así mismo se analizó el uso de ventilación mecánica en paciente con presencia de LRA, siendo un total de 64 pacientes (59.6%), esto contribuye a un incremento de la mortalidad, son similares los resultados a los obtenidos en el estudio de Davide Ottolina et al. en 2021 con una población de 101 pacientes, en el cual se analizó el uso de VMI, la cual tuvo un incremento en el desarrollo de LRA, con un incremento en la mortalidad, observándose que los valores de PEEP bajo tuvieron una mortalidad menor (42%) con respecto a los que se trataron con niveles de PEEP alto (69%) 20 . ...
... Recently, it was reported that neutrophil-to-lymphocyte ratio (NLR) served as a biomarker of severe infection, vasculitis activity, relapse, renal prognosis, and allcause mortality in AAV. However, whether NLR was related to long-term survival in AAV was controversial (14)(15)(16)(17). Platelet-tolymphocyte ratio (PLR) was identified to be an independent predictor of current vasculitis activity in AAV (18). ...
... Carpenè et al. (86) demonstrated that blood lactate levels were higher in severe cases of non-survivor patients with COVID-19 than in non-severe survivor cases, as shown in Supplementary Figure 2 (87)(88)(89)(90)(91)(92)(93)(94)(95)(96). Figure 2 shows the blood lactate levels in coronavirus disease 2019 (COVID-19) survivors vs. non-survivors taken from the results of references 87-96, suggesting that the blood lactate levels in COVID-19 non-survivors are significantly higher than the survivors. The results of Supplementary Figure 2 show that in long COVID patients, intracellular energy production tends to use glycolysis rather than using mitochondrial oxidative phosphorylation. ...
... Glomerulonephritis, on the other hand, is primarily an inflammatory disease which results in a congregation of inflammatory molecules that damages the glomeruli. Likewise, several investigators have previously reported that NLR was not only associated with renal function [72][73][74] but also predicted the deterioration of kidney function and CVD [21,[75][76][77] in various types of glomerulopathies including lupus, vasculitis and IgA nephropathy. ...
... Duarte, Inês, et al. . found hypoalbuminemia and higher CRP as predictors for mortality in AKI-D patients (26) . Consistent with the literature, we found high levels of CRP, hypoalbuminemia, and hypotension to be factors predicting mortality in our study. ...
... Aligned with our findings, one retrospective study among elderly patients showed that AKI duration of more than seven days increased the risk of CKD [24]. Another retrospective study found an OR of 23.7 for CKD in patients with an AKI duration of more than seven days [25]. However, the Acute Dialysis Quality Initiative (ADQI) proposed a standardized definition of persistent AKI based on the recovery of kidney function within 48 h, which is consistent with the definition used in the EPIS-AKI study [15]. ...
