I. Pangrazzi's research while affiliated with Mario Negri Institute for Pharmacological Research and other places
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Publications (3)
Aspirin therapy reduces the risk of cardiovascular disease in adults who are at increased risk. However, it is unclear if women derive the same benefit as men.
To determine if the benefits and risks of aspirin treatment in the primary prevention of cardiovascular disease vary by sex.
MEDLINE and the Cochrane Central Register of Controlled Trials da...
Citations
... Other studies showed that lipid peroxidation is inhibited by supplementation with vitamin E, sesamin, and sesamolin [46,50,[58][59][60][61]. Antioxidant effects improve endothelial dysfunction by reducing free radicals [51] and lead to an increase in vasodilator or nitric oxide factors [62]. However, a number of studies related to vitamin E do not confirm these results [63][64][65]. ...
... The former depends on vascular tone while natriuresis intensity constitutes an important factor regulating the latter through changes in blood volume and subsequently in central venous pressure. Despite a clear association between NSAIDs use and rise in blood pressure, the relationship between aspirin and blood pressure is inconclusive192021222324252627. A pooled analysis of five cohort studies demonstrated an 18% increase in the risk of hypertension among patients treated with aspirin [21] in contrast to the demonstration of an absence of influence of aspirin dose on blood pressure in two large meta-analyses [19, 20]; moreover, in two other studies, aspirin administered at bedtime lowered blood pressure [22, 23] . ...
... With regards to CV drugs, in primary prevention studies, while aspirin lowered the risk of stroke it did not reduce myocardial infarction or CV death in women compared with men [24]. Similarly, the effects of statins in primary prevention are less evident in women [25]. ...
