I. Gurevic's research while affiliated with University of Wisconsin–Madison and other places
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Publications (6)
Objectives:
Sjӧgren's disease (SjD) is a systemic autoimmune disease characterized by focal lymphocytic infiltrate of salivary glands (SGs) and high SG IFNγ, both of which are associated with elevated lymphoma risk. IFNγ is also biologically relevant to mesenchymal stromal cells (MSCs), a SG resident cell with unique niche regenerative and immunor...
Citations
... This elevation presumably facilitates the migration of circulating Vδ2 T cells. CXCL-10 is mainly secreted by monocytes, endothelial cells, fibroblasts, mesenchymal stromal cell (MSC) 42 and cancer cells in response to IFN-γ, which is synergistically enhanced by TNF-α. The activation of IFN-regulatory factor 3, toll-like receptors (TLR), retinoic acid-inducible gene (RIG)-I, and melanoma differentiation-associated gene (MDA)-5 synergistically collaborates with IFNs to induce CXCL10 induction. ...