Huan-Huan Chen's research while affiliated with Guangxi Academy of Sciences and other places

... SIVA protein has an amphipathic helical (SAH) region at the N-terminus, a death domain homology region (DDHR) in the middle, and the box-B-like ring finger and two zinc fingerlike cysteine rich domain at the C-terminus [37]. Previous studies have identified the SAH and DDHR regions as essential for the pro-apoptotic function of SIVA [38]. The mutation (c. ...

... Furthermore, opportunistic pathogens such as Ruminococcaceae_NK4A214_group, Ch-ristensenellaceae_R-7_group, Anaerotruncus, Mycobacterium and the species Megasphaera micronuciformis were positively correlated with pro-inflammatory cytokines and inflammation [42][43][44][45][46]. ...

... (13%); however, worldwide, over 100 different fungal species have been associated with the condition [1]. Fungal taxonomy and nomenclature have undergone significant changes over the past 10-15 years as genomic phylogenetic analyses augment traditional phenotypic characterisation, leading to changes in the nomenclature and species of organisms associated with different infection types [4]. ...

... Angiogenesis is the process by which new blood vessels develop from existing capillaries or venules and eventually create mature vasculature from budding or nonbudding forms. This process includes the activation, proliferation, and migration of vascular endothelial cells, which are important signs of angiogenesis and the necessary early steps of the angiogenic cascade [40,41]. The basic principle of angiogenesis experiments is that endothelial cells retain their ability to divide and migrate in response to angiogenic signals; therefore, HUVEC proliferation and migration experiments have been widely used to simulate and reflect the process of tumor angiogenesis [42,43]. ...

... Sirtuins are involved in a variety of metabolic regulation and biological processes, such as cell survival, apoptosis, proliferation, cellular senescence, stress response, inflammation, oxidative stress, mitochondrial production, genome stabilisation and metabolism. The complexity of the interactions between sirtuins provides a degree of support for their role as essential regulators of cellular biology [23] (Figs. 1 and 2). ...

... • transcriptional level to support bioenergetic and biosynthetic demands of rapid proliferation [53]. • Stem cell regulation: miRNAs are implicated in the self-renewal and differentiation of normal and cancer stem cells, believed to drive tumor initiation and recurrence [54]. ...

... Deacetylation and control of the mitoacetylome account for a crucial mechanism to regulate the activity or function of many substrates. These substrates include acyl-CoA dehydrogenases and the rate-limiting enzyme, pyruvate dehydrogenase, involved in the regulation of energy metabolism [57]. SIRT3 is highly expressed in tissues with a high metabolic rate, such as the kidneys, heart, and liver [58,59]. ...

... These observations are part of a growing body of evidence from other types of cancer, such as breast, ovarian, and colorectal cancers, that demonstrate the key role of microRNAs in mediating cancer development, progression, and response to treatment [16][17][18]. Based upon this information, more research has been focused in recent years on identifying specific microRNAs and their corresponding downstream targets that may function as biomarkers to determine radiation or chemotherapy resistance and sensitivity in patients [19,20]. ...

... Zhujiangyuan Nature Reserve in Yunnan Province, China, harbours a large number of native evergreen and deciduous plant species and we predict this region has higher fungal diversity, although many are yet to be discovered (Feng and Yang 2018;Luo et al. 2018;Dai et al. 2019Dai et al. , 2022Wijayawardene et al. 2021Wijayawardene et al. , 2022c. Wijayawardene et al. (2022b) emphasized the importance of collecting materials from under-studied geographical locations as even, some extensively studied hosts could still harbour novel taxa. ...

... Lung cancer is the leading cause of cancer deaths in the world. [1] Mostly, lung cancer is not detected until it is at an advanced stage and more than half of the patients are diagnosed at the most advanced stage IV when curative therapy is usually not possible anymore. [2] Therefore, early detection of lung cancer is of fundamental importance in cancer treatment given a drop in the 5-year survival rate from 70-90% in stage I to 0-10% in stage IV. ...