Hiroshi Nitta's research while affiliated with National Institute for Environmental Studies and other places
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Publications (174)
Background:
To our knowledge, the association of maternal exposure to metallic elements with weight trajectory pattern from the neonatal period has not been investigated.
Objectives:
The goals of this study were to identify infant growth trajectories in weight in the first 3 y of life and to determine the associations of maternal blood levels of...
Introduction:
PM2.5 exposure is a suspected risk factor for diabetes. It is hypothesized that maternal PM2.5 exposure contributes to the development of gestational diabetes mellitus (GDM). The association between PM2.5 exposure and GDM is controversial and limited evidence is available for the exposure to PM2.5 chemical components. We investigated...
A limited number of studies have investigated the association between short-term exposure to PM2.5 components and morbidity. The present case-crossover study explored the association between exposure to total PM2.5 and its components and emergency ambulance dispatches, which is one of the indicators of morbidity, in the 23 Tokyo wards. Between 2016...
Background
Maternal exposure to fine particulate matter (PM2.5) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM2.5 are more harmful for maternal and foetal health.
Objective
We focused on exposure over the first trimester (0–13 weeks of gestation), which...
Rationale
Epidemiological evidence indicates that ambient exposure to particulate matter ⩽2.5 μm in aerodynamic diameter (PM2.5) has adverse effects on lung function growth in children, but it is not actually clear whether exposure to low-level PM2.5 results in long-term decrements in lung function growth in pre- to early-adolescent schoolchildren....
Background
Our hypothesis was that exposure to fine particulate matter (PM2.5) is related to abnormal cord insertion, which is categorized as a form of placental implantation abnormality. We investigated the association between exposure to total PM2.5 and its chemical components over the first trimester and abnormal cord insertion, which contribute...
Objective:
We investigated which trimester of exposure to PM2.5 and its components was associated with birth and placental weight, and the fetoplacental weight ratio.
Methods:
The study included 63,990 women who delivered singleton term births within 23 Tokyo wards between 2013 and 2015. Each day, we collected fine particles on a filter, and ana...
Exposure to ambient air pollution is associated with maternal and child health. Some air pollutants exhibit similar behavior in the atmosphere, and some interact with each other; thus, comprehensive assessments of individual air pollutants are required. In this study, we developed national-scale monthly models for six air pollutants (NO, NO2, SO2,...
Fine particulate matter (PM2.5) is composed of a variety of chemical components, and the dependency of the health effects of total PM2.5 on specific components is still under discussion. We hypothesised that specific PM2.5 components are responsible for the health effects, and investigated the association between PM2.5 components and mortality in 2...
Clinical guidelines including those set by the US Institute of Medicine, have based optimal gestational weight gain (GWG) on maternal pre-pregnancy body mass index (BMI), but have not considered the role of environmental toxicants such as heavy metals that can disrupt these processes. This study designed to determine optimal GWG ranges in women gro...
Background:
The Japan Environment and Children’s Study (JECS) is a nationwide birth cohort study investigating environmental effects on children’s health and development. A Sub-Cohort Study has begun, conducting extended exposure and outcome measurements by targeting a subgroup randomly selected from the JECS Main Study. We report the Sub-Cohort St...
Objective:
For several observational studies that have reported the factors related to gastroschisis, the target population in these studies was mainly residents of Europe or the US, and there is little data on the Asian population. In this study, we summarised characteristics of Japanese women who delivered infants with gastroschisis, particularl...
Background:
Despite dramatic declines in prenatal maternal blood lead levels (BLLs) in most developed countries, little is known about the effects of extremely low-level (<1.0 µg/dL) lead exposure on fetal growth.
Methods:
We measured maternal BLL during the second or third trimester of pregnancy and assessed birth outcomes, including birthweigh...
Background
There is growing evidence of an association between cadmium (Cd) and unfavorable birth outcomes. The effect of Cd exposure on anthropometric measures at birth or small for gestational age (SGA) infants in a large, nationwide Japanese cohort remains to be clarified.
Objectives
To analyze the association between maternal blood Cd levels a...
Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative to urinary biomarkers. This study investigated urinary cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in the Japan Environment and Children’s Study, a nationwide birth coho...
Aim: To examine the association between long-term exposure to suspended particulate matter (SPM) and cardiovascular mortality in Japan after controlling for known major confounding factors among a large middle and elderly cohort study in Ibaraki Prefecture, Japan.
Methods: We followed 91,808 residents (men 34%) who undertook a national health check...
The occurrence of anorectal malformations (ARMs) is thought to be reduced with sufficient folate intake. However, there is no apparent evidence. We focused on enzyme cofactors for one-carbon metabolism, including folate (vitamin B 9 ), vitamin B 6 , and vitamin B 12 , and explored the association between maternal combined intake of these B vitamins...
Objectives
No previous study has used repeated measures data to examine the associations of dog/cat ownership with wheezing and asthma prevalence among children. This prospective study used repeated measurers analysis to determine whether dog/cat ownership in childhood is an independent risk factor for wheezing and asthma, after adjustment for gest...
Importance
Out-of-hospital cardiac arrests (OHCAs) are a major public health concern and a leading cause of death worldwide. Exposure to ambient air pollution is associated with increases in morbidity and mortality and has been recognized as a leading contributor to global disease burden.
Objective
To examine the association between short-term exp...
Poly- and perfluoroalkyl substances (PFAS) have been investigated in a number of cohort studies due to concern over their adverse health effects. The aim of this study was to develop a reliable, high throughput and cost-effective analytical method for a broad range of PFAS in human serum. Protein precipitation, automatic solid phase extraction (SPE...
Exposure to fine particulate matter (PM2.5) is a potential aggravating factor for respiratory and allergic diseases. However, which PM2.5 sources are associated with such diseases remains unclear. This study aimed to investigate the association of PM2.5 sources with allergic and respiratory symptoms in schoolchildren. PM2.5 samples were collected i...
Objective:
Asian dust is a natural phenomenon in which dust particles transported from desert areas in China and Mongolia to East Asia. Short-term exposure to Asian dust has been associated with cardiovascular disease through mechanisms, such as systemic inflammation. Because inflammation is a potential trigger of placental abruption, exposure may...
Automated identification and determination system using a gas chromatograph-mass spectrometry (AIQS-GC) is a technology that enables semi-identification and quantification of substances without using the standard substance. Using this method, environmental water monitoring around the disaster temporary storage area after the Great East Japan Earthq...
The pathogenesis of congenital diaphragmatic hernia (CDH) is largely unknown; however, vitamin A seems to play a role in diaphragmatic development. Previous, case-control studies reported that maternal dietary vitamin A intake was inversely associated with the risk of CDH. To our knowledge, however, there is no prospective evidence regarding this a...
Background:
This study aimed to determine the psychometric profiles of 10 questionnaires (every 6 months, from 6 to 60 months) from the Japanese translation of the Ages and Stages Questionnaires, third edition (J-ASQ-3).
Methods:
Data from 439 children in a birth cohort were used to identify the J-ASQ-3 score distribution, establish cutoff score...
On 11 March 2011, the Great East Japan Earthquake has brought about significant damage in the Tohoku and Kanto areas. The greatest tsunami caused massive damage to coastal areas in the Tohoku region such as Miyagi Prefecture. There was a concern about the effects of particulate matter (PM) derived from tsunami sediment on human health. In this stud...
The disaster waste from the massive tsunami that occurred as a result of the Great East Japan Earthquake, in March, 2011, was stacked at temporary storage sites managed by local authorities. In June, 2011, we have conducted a research at a high school in Ishinomaki City, Miyagi Prefecture, on flies and airborne microorganisms which were considered...
Background:
It is necessary to determine whether there are adverse health effects of prenatal exposure to long-term, low levels of mercury and selenium. However, there are limited that reports on the association between mercury levels by selenium levels and birth size. Therefore, we examined whether maternal mercury levels during pregnancy had any...
The Japan Environment and Children’s Study (JECS) is a birth-cohort study of 100,000 mother–child dyads that aims to investigate the effect of the environment on child health and development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) and selenium (Se) are considered to be important co-exposures when examining the effect of other chemica...
Background:
Manganese (Mn) is both an essential element and a potential toxicant. Although a few studies have suggested a nonlinear relationship between the maternal whole blood Mn level at delivery and infant birth weight, little is known about the effects of Mn levels during pregnancy on fetal growth, particularly with regard to sex-specific dif...
Objective
To explore the association between isoflavone intake in early pregnancy (the critical window of masculinisation) and hypospadias. Since oestrogen is likely to contribute to the differentiation of male external genitalia, dietary intake of isoflavone, which has a similar structure to human oestrogen, may be associated with the occurrence o...
Current evidence suggests that the aetiology of congenital gastrointestinal (GI) tract atresia is multifactorial, and not based solely on genetic factors. However, there are no established modifiable risk factors for congenital GI tract atresia. We used data from a Japanese nationwide birth cohort study launched in 2011, and examined whether fish c...
Background: From around 2012, the use of automated equipment for fine particulate matter (PM2.5) measurement with equivalence to a reference method has become popular nationwide in Japan. This enabled us to perform a national health effect assessment employing PM2.5 concentrations based on the standardised measurement method. We evaluated the assoc...
Background:
The Japan Environment and Children's Study (JECS) is a nation-wide birth cohort study investigating environmental effects on children's health and development. In this study, the exposure characteristics of the JECS participating mothers were summarized using two questionnaires administered during pregnancy.
Methods:
Women were recru...
Short-term health effects of ambient PM2.5 have been established with numerous studies, but evidence in Asian countries is limited. This study aimed to investigate the short-term effects of PM2.5 on acute health outcomes, particularly all-cause, cardiovascular, respiratory, cerebrovascular and neuropsychological outcomes. We utilized daily emergenc...
Background
Numerous earlier studies examining the association of air pollution with maternal and foetal health estimated maternal exposure to air pollutants based on the women’s residential addresses. However, residential addresses, which are personally identifiable information, are not always obtainable. Since a majority of pregnant women reside n...
Evidence supporting an inverse association between maternal exposure to air pollutants and foetal growth has been accumulating. However, the findings from Asian populations are limited, and the question of critical windows of exposure remains unanswered. We examined whether maternal exposure to air pollutants, in particular exposure during the firs...
Background: The Japan Environment and Children’s Study (JECS), known as Ecochil-Chosa in Japan, is a nationwide birth cohort study investigating the environmental factors that might affect children’s health and development. We report the baseline profiles of the participating mothers, fathers, and their children.
Methods: Fifteen Regional Centres l...
Fetal heart rate (FHR) monitoring is essential for fetal management during pregnancy and delivery but results in many false-positive diagnoses. Air pollution affects the uterine environment; thus, air pollution may change FHR reactivity. This study assessed the association between exposure to air pollution during pregnancy and FHR monitoring abnorm...
Introduction:
One of the ethical issues surrounding birth cohort studies is how to obtain informed assent from children as they grow up. What and how parents tell their children affects children's future choices about the study, yet few studies have focused on parents' influence on children.
Objective:
This study examines parents' attitudes towa...
Aims:
To elucidate whether Asian dust is associated with the incidence of acute myocardial infarction (AMI) and to clarify whether patients who are highly sensitive to Asian dust will develop AMI.
Methods and results:
Twenty-one participating institutions located throughout Kumamoto Prefecture and capable of performing coronary intervention were...
The recent development and use of autism measures for the general population has led to a growing body of evidence which suggests that autistic traits are distributed along a continuum. However, as most existing autism measures were designed for use in children older than age 4, to date, little is known about the autistic continuum in children youn...
Background:
Placental abruption is an emergency obstetric complication. Although the etiology of abruption is not fully understood, acute stimuli, such as ischemia and/or inflammation, are associated with rupture of the decidual artery, resulting in placental separation. Ischemia and inflammation are acute biologic effects of air pollution. Using...
Background and purpose:
There is a strong association between ambient concentrations of particulate matter (PM) and cardiovascular disease. However, it remains unclear whether acute exposure to fine PM (PM2.5) triggers ischemic stroke events and whether the timing of exposure is associated with stroke risk. We, therefore, examined the association...
Short-term exposure to air pollution may be linked to negative health outcomes that require an emergency medical response. However, few studies have been undertaken on this phenomenon to date. The aim of this study therefore was to examine the association between short-term exposure to ambient suspended particulate matter (SPM) and emergency ambula...
Background:
Placenta praevia is an obstetric complication involving placental implantation in the lower uterine segment. Given the suggested aetiology of placenta praevia, adverse biological effects of air pollutants, such as plasma viscosity increment, endothelial dysfunction, and systemic inflammation, have the potential to induce low implantati...
A suggestive mechanism behind the association between particulate matter and cardiovascular disease is inflammatory response. Earlier population-based studies investigating the association between particulate matter and inflammatory biological markers, in particular C-reactive protein (CRP), showed inconsistent results. In addition, evidence from t...
Objectives There has been little study on the effect of traffic-related air pollution on the incidence and persistence of asthma in preschool children. We evaluated the association of exposure to traffic-related air pollution with the incidence/persistence of asthma during the first 3 years of life using a population-based study.
Methods A baseline...
Background:
Seasonal variation and regional heterogeneity have been observed in the estimated effect of fine particulate matter (PM2.5) mass on mortality. Differences in the chemical compositions of PM2.5 may cause this variation. We investigated the association of the daily concentration of PM2.5 components with mortality in Nagoya, Japan.
Metho...
Objective:
This study clarified sensitization patterns to house dust mite (HDM) and Japanese cedar pollen (JCP) in Japanese lower-grade schoolchildren. We also explored factors associated with allergic sensitization.
Methods:
This cross-sectional study used a database from the Study on Respiratory Disease and Automobile Exhaust (SORA), a Japanes...
Ambient air pollution is hypothesized to be a risk factor for hypertensive disorders in pregnancy, one of the major pregnancy complications. Past studies have reported the supporting evidence, however this mainly referred to the Western population, and results from trimester-specific analysis have been varied. In this study, we focused on exposure...
The Japan Environment and Children's Study (JECS) is an ongoing nationwide birth cohort study launched in January 2011. In this progress report, we present data collected in the first year to summarize selected maternal and infant characteristics.
In the 15 Regional Centers located throughout Japan, the expectant mothers were recruited in early pre...
There is no conclusive evidence of adverse health effects caused by short-term exposure to coarse particulate matter, so in this case-crossover study we looked for an association between exposure and emergency ambulance dispatches (as a proxy of acute health outcomes).
We used data on emergency ambulance dispatches in Fukuoka City, Japan between 20...
Introduction: Air pollution, a mixture of gases and particles that come from manmade and natural sources, has been shown to increase hospi¬tal admission and mortality attributable to cardiovascular diseases. Asian dust (AD), a windblown sand dust originating from mineral soil in the desert, and PM2.5, which comes from cars and trucks, power plants,...
Epidemiological studies have reported an increased risk of cardiopulmonary and lung cancer mortality associated with increasing exposure to air pollution. Ambient particulate matter consists of primary particles emitted directly from diesel engine vehicles and secondary organic aerosols (SOAs) are formed by oxidative reaction of the ultrafine parti...
Background Evidence of an association between fine particulate matter (PM2.5) and morbidity is limited in Asia. We used a case-crossover design to evaluate the association between short-term exposure to PM2.5 and emergency ambulance dispatches (as a proxy of acute health outcomes), and to calculate the extent to which a 10 μg/m3 decrease in PM2.5 c...
Background:
Recently, there has been increasing concern about adverse health effects of exposure to desert dust events. However, the association between dust and the incidence of ischemic heart diseases is unknown. The aim of the present study was to elucidate whether Asian dust (AD), a windblown sand dust originating from mineral soil in China an...
Air pollution is widely understood to be capable of exacerbating asthma symptoms. Here we examined the association between traffic-related air pollution and development of asthma in school children. Subjects were 10,069 school children in their first through third years of compulsory education (6-9-year old). The main outcome was incidence of asthm...
There is global concern over significant threats from a wide variety of environmental hazards to which children face. Large-scale and long-term birth cohort studies are needed for better environmental management based on sound science. The primary objective of the Japan Environment and Children's Study (JECS), a nation-wide birth cohort study that...
Background:
Ambient temperature affects mortality in susceptible populations, but regional differences in this association remain unclear in Japan. We conducted a time-series study to examine the variation in the effects of ambient temperature on daily mortality across Japan.
Methods:
A total of 731 558 all-age non-accidental deaths in 6 cities...
We conducted a multicity time-series study using monitoring data to assess seasonal patterns of short-term ozone-mortality association among elderly aged 65 years and over in Japan. Daily exposure to ambient ozone was computed using hourly measurements of photochemical oxidants available at multiple monitoring stations in each city. Effects of ozon...
Previously, we demonstrated that maternal exposure to phthalates enhances atopic dermatitis in male mouse offspring. However, whether phthalate exposure affects neuroimmune biomarkers in allergic mice has not yet been studied. Di-(2-ethylhexyl) phthalate (DEHP) and di-isononyl phthalate (DINP) are environmental chemicals that are commonly used as p...
Backgrounds: Recently, Asian dust (AD) and air pollution have been recognized as a cause of cardiovascular diseases, such as ischemic stroke. However, the association between AD, a windblown sand dust originating from mineral soil in China and Mongolia, and the incidence of ischemic heart disease, such as acute myocardial infarction (AMI), is unkno...
The Japanese Government has conducted total diet studies (TDSs) annually since 1977, based on GEMS/Food Programme recommendations, to estimate average Japanese dietary exposure to various pesticides, heavy metals, dioxins, food additives, and other potentially hazardous chemicals. The concentrations of the chemicals in food composite samples compri...
We developed an exposure estimation model for an epidemiological study on the effect of traffic-related air pollutants on respiratory diseases. The model estimates annual average outdoor concentration of nitrogen oxides (NOx) and elemental carbon (EC). The model is composed of three nested plume dispersion type submodels treating different spatial...
Despite rising concern on the impact of heat on human health, the risk of high summer temperature on heatstroke-related emergency dispatches is not well understood in Japan. A time-series study was conducted to examine the association between apparent temperature and daily heatstroke-related ambulance dispatches (HSAD) within the Kanto area of Japa...
Recently, we have reported that primary particles from diesel exhaust affect nervous system, immune system, and learning ability in mice. Currently, in vivo and in vitro studies have shown that secondary organic aerosol (SOA) generated from the coal-fired power plant induced adverse effects in lung and heart. However, the effect of SOA on central n...
Aim:
Associations between long-term exposure to particulate matter (PM) and increased cardiovascular mortality have been reported, but few studies have investigated the associated incidence of cardiovascular disease, and none involved men.
Methods:
We used data on 78,057 participants (37,121 men, 40,936 women) to examine the associations of long...
Asian Dust (AD) particles transported from source areas contribute to sharp increases in coarse particles in Japan. We examined the association of exposure to AD events with emergency ambulance dispatches in Nagasaki city. We also examined whether AD transported at different altitude routes from source areas influenced dispatch rates. Using lidar (...
Background and purpose:
Particulate matter is increasingly recognized as a cause of human diseases, including cardiovascular diseases. However, the association between Asian dust (AD), a windblown sand dust originating from mineral soil in the deserts of China and Mongolia, and the incidence of cardiovascular diseases is unclear. The aim of the pr...
Background:
Apart from the conventional risk factors, cerebro-cardiovascular disease (CVD) are also reported to be associated with air pollution, thus lowering the level of exposure might contribute in prevention activities to reduce the associated adverse outcomes. Though few studies conducted in Japan have reported on the CVD mortality but none...
Citations
... To date, pesticide residues have not been evaluated in the NHNS. In Japan, pesticide residues are mainly evaluated using blood and urine (87,88) , and there are few studies on dietary exposure for representative Japanese populations (89,90) . The evaluation of pesticide residues using blood and urine do not provide estimation of long-term dietary exposure. ...
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... The salts in PM 2.5 , such as NO 3 − and NH 4 + , were associated with allergic rhinitis, airway inflammation, and adverse effects on lung function in children [16, [44][45][46][47]. Long-term exposure to SO 4 2− or OC was found to be linked to the development of diabetes [48,49]. Heavy metal ion constituents in PM 2.5 , such as Pb, were associated with ischemic stroke, while Ni was associated with blood pressure; Fe, Cu, and Zn were associated with respiratory and cardiovascular mortality [50][51][52]. ...
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... Kawasaki was classified as an urban and industrial monitoring site. Epidemiological studies in the Tokyo Metropolitan Area have shown that short-term exposure to PM 2.5 is associated with ambulance dispatches (Michikawa et al., 2022). ...
... Airborne particulate matter is a major health problem that is estimated to cause 4.14 million premature deaths worldwide each year (Fuller et al. 2022). The correlation between adverse health effects and particle concentrations in ambient air is well known, and recent studies have indeed found an association between particulate matter (PM) exposure and, for example, impaired lung function (Chen et al. 2019;Takebayashi et al. 2021, Fussell et al. 2022. Particle concentrations are often particularly high in urban areas, resulting in high exposure levels for many people. ...
... Placental vascular indices assessed by ultrasound imaging during the first trimester were lower in women with GDM than in those without GDM (37) . Our previous findings suggested that PM 2.5 exposure affected maternal and fetal health from early pregnancy (38) . However, our findings in the multiexposure period model were inconsistent with those of some previous epidemiological studies in terms of the susceptible period for PM 2.5 exposure associated with GDM. ...
... The bar dash label represents the monthly average PM 2.5 concentration from January to December. fold site-based CV (de Hoogh et al., 2018;Chen et al., 2019;Araki et al., 2020;Araki et al., 2021;and Thongthammachart et al., 2022) to evaluate the model ability to predict the concentrations at unmonitored locations. For model fitting, we constructed the LUR model with whole datasets. ...
... Particulate matter (PM) which is a mixture of organic and inorganic compounds and elements suspend and transport for long time and distances in ambient air, is directly responsible to aggravate many incurable childhood diseases including post-neonatal infant mortality and sudden infant death syndrome (SIDS) [1][2][3]. In Japan, PM polluted air has been observed to be associated with severe health problems for healthy school children and pregnant women during spring and summer in the west of Japan (Kyushu Island) [4][5][6]. Therefore, applying various techniques and methods can decline high concentrations of PM, as stated in 2018 annual report of Japanese Ministry of Environment, which declared that achievement rate of Japan Environmental Standards for fine particulate matter (PM2.5) has recently increased from 30-40% from 2010-2014 to over 80% in 2017, even though, PM concentration still increasing steadily and using such techniques can be costly and complicated. ...
... Moreover, there is also proof for links between air pollution and specific illnesses. Substances like PM 2.5 , PM 10 , NO x , O 3 and SO 2 influence cardiac arrests [10], cardiac arrhythmia [11], cognitive decline in adult population [12], Covid-19 incidence [13], development of chronic kidney disease [14] or Type 2 diabetes [15]. PM 2.5 and PM 10 are also linked to hospital admissions for cardiovascular [16] and respiratory diseases [17]. ...
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... Exposure only to non-hydrocarbon particulate air pollution is not clearly associated increased preeclampsia risk [47] [48]. An analysis of components of fine particulate air pollution shows specific components differentially increase preeclampsia risk with organic carbon components having greater adverse effect [49]. From these studies, it appears air pollution which contains pollutants such as benzene, toluene, xylene (volatile organic compounds) and oil, tar, gasoline, and diesel combustion components that may be absorbed through lung alveolar surface may be the source of increased preeclampsia risk. ...
... Those residing outside the study areas were excluded, even if they visit cooperating healthcare providers within those areas. As a subcohort study of the JECS, metal concentrations in cord blood were measured from randomly sampled participants who had comprehensive questionnaire data, medical record transcripts, and biospecimens obtained from the pregnancy period until the infants turned 6 months old [25]. In 103,060 pregnancies registered in the JECS, blood samples from 96,696 pregnant women were used to measure Cd, Hg, Pb, Se, and Mn concentrations. ...
