Hetong Zhao's research while affiliated with Shanghai University of Traditional Chinese Medicine and other places
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Publications (14)
Tongue diagnosis is a unique aspect of traditional Chinese medicine for diagnosing diseases before determining proper means of treatment, but it also has the disadvantage of relying on the subjective experience of medical practitioners and lack objective basis. The purpose of this article is to elucidate tongue-coating microbiota and metabolic diff...
Background:
Transarterial chemoembolization (TACE) is the most common treatment for patients with HCC who are unsuitable for radical therapies. Conventional TACE (cTACE) takes advantage of the preferential hepatic arterial supply of HCC for the targeted delivery of chemotherapeutic agents suspended in lipiodol, followed by embolization or reductio...
Ferroptosis exerts a pivotal role in the formation and dissemination processes of hepatocellular carcinoma (HCC). The heterogeneity of ferroptosis and the link between ferroptosis and immune responses have remained elusive. Based on ferroptosis-related genes (FRGs) and HCC patients from The Cancer Genome Atlas (TCGA), International Cancer Genome Co...
Hard metal lung disease (HMLD) drugs include dexamethasone sodium phosphate (Dex), methylprednisolone (MP) injection, N-acetylcysteine injection (NAC), and a mix of Dex, MP, and NAC (MIX). In this study, we compared the effects of these drugs on different cytokines of hard metal lung disease in a rat model. Thirty-six adult female Sprague Dawley ra...
This study aimed to investigate the underlying molecular pathogenic mechanism of Sec62 in hepatocellular carcinoma (HCC). Microarray analysis was conducted to profile the global gene expression in the HCC cell line Huh7 cells transfected with Sec62high vs. NC and Sec62low vs. NC. Ingenuity pathway analysis and gene set enrichment analysis were used...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and N6-methyladenosine (m6A) is a predominant internal modification of RNA in various cancers. We obtained the expression profiles of m6A-related genes for HCC patients from the International Cancer Genome Consortium and The Cancer Genome Atlas datasets. Most of th...
Chaperonin containing TCP-1 (T-complex protein 1) (CCT) is a large molecular weight complex that contains nine subunits (TCP1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT6B, CCT7, CCT8). This study aimed to reveal key genes which encode CCT subunits for prognosis and establish prognostic gene signatures based on CCT subunit genes. The data was downloaded fr...
Purpose:
Esophageal squamous cell carcinoma (ESCC) remains a common aggressive malignancy in the world. Several long non-coding RNAs (lncRNAs) are reported to predict the prognosis of ESCC. Therefore, an in-depth research is urgently needed to further investigate the prognostic value of lncRNAs in ESCC.
Results:
From the training set, we identif...
Postsurgical recurrence within 2 years is the major cause of poor survival of hepatocellular carcinoma (HCC) patients. However, the molecular mechanism underlying HCC recurrence remains unclear. Here, we distinguish the function and mechanism of Sec62 in promoting HCC recurrence. The correlation between Sec62 and early recurrence was demonstrated i...
Complement factor H‐related 3 (CFHR3) is a protein‐coding gene acting in various diseases. However, its prognostic values of CFHR3 in hepatocellular carcinoma (HCC) are not understandable. Therefore, we present a further study on CFHR3 in HCC. CFHR3 expression data were acquired from The Cancer Genome Atlas (TCGA) and the International Cancer Genom...
The aim of the present study was to compare the effectiveness of transarterial chemoembolization (TACE), TACE combined with Jie-du granules (JD), and TACE combined with sorafenib (SOR) for treating patients with unresectable hepatocellular carcinoma (HCC). For this purpose, we conducted a retrospective analysis of data from 266 consecutive patients...
Background
The efficacy of transoral incisionless fundoplication (TIF) performed with the EsophyX device (Redmond, Washington, USA) and its long-term outcomes in gastresophageal reflux disease (GERD) are debated. We, therefore, performed a systematic review with meta-analysis of studies evaluating the role of TIF in GERD.
Methods
A systematic searc...
Citations
... All the participants were asked to fast overnight (≥ 8 h) and did not brush their teeth in the morning. Salivary and tongue coating sample collection and preparation were carried out in accordance with previously published consensus [26,27]. Thirty minutes before sampling, participants were asked to rinse their mouths by gargling with sterile saline, and then 2 ml of saliva was collected in sterilized tubes. ...
... 12,13 Additionally, to enhance safety, a portion of its E3 region has also been deleted. 14 It has been shown to enhance transarterial chemoembolization (TACE) for HCC [15][16][17] and conventional chemotherapy for other tumors. [18][19][20] Approved in China for advanced nasopharyngeal carcinoma since 2005, H101 represents the first OV to gain regulatory approval. ...
... We compared our own model to 12 other published HCC prognostic models to better highlight its predictive capability (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). Using multivariate analysis, we determined the risk value and prognosis evaluation for each dataset, making the 13 models comparable. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1000458361524225-1615539269593_Q64/Zhang-Dangui.jpg)
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... Angiogenesis, both in its natural and abnormal forms, involves the formation and progression of new blood vessels, which are crucial for supplying tumors with vital oxygen and nutrients. Consequently, angiogenesis significantly influences the proliferation and metastasis of tumors [2][3][4]. Addressing the clinical challenges posed by HCC, particularly in its advanced stages, has been a longstanding concern. In recent years, anti-angiogenesis therapy has emerged as a promising approach to cancer treatment, drawing significant attention. ...
... Expression levels of these proteins are significantly upregulated in HCC samples. 79,94,95 Methyltransferases regulate the interplay between the transcriptome and epitranscriptome during RNA methylation. They facilitate transcriptional dormancy through interconnected mechanisms relevant to the dormancy of adult stem cells and cancer. ...
... Abnormal CCT expression protein can lead to disrupted tumor cell metabolism and apoptotic signaling, fostering tumorigenesis. For instance, CCT2 has been found to regulate metastasis and drug resistance in malignant tumors like breast cancer and glioma [16,17]; the expression of CCT4 and CCT6A can be utilized in the prognostic analysis of liver cancer [18]. Yet, the impact of CCT and its components on LUAD remains unclear. ...
... 9 Additionally, in the cancer immunity response and the tumor microenvironment, lncRNAs have multiple functions. [10][11][12] There is a significant amount of evidence supporting lncRNAs as possible diagnostic biomarkers and therapeutic targets, 13 thereby lncRNAs cannot simply be regarded as the "noise" of genomic transcription. Considering the roles of mRNA and lncRNA in cancer biology, the prognostic signature that combines these two factors has a superior effect. ...
... Ln-332/integrin a3/FAK Induce HCC cells' resistance to sorafenib [53] a3b1 Ln-5/integrin a3b1/ERK Stimulate HCC growth [54] a5 Sec62/integrin a5/CAV1 Promote HCC metastasis and early recurrence [55] a5b1 ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/375974156881921-1466650632533_Q64/Ling-Changquan.jpg)
... SOX11 was also significantly upregulated in HCC [22]. FTCD, ADH4, CFHR3, CYP2C9, CCL14, GADD45G was down-regulated in HCC [23][24][25][26][27][28]. These papers supported the high accuracy of our prognostic model. ...
... The combination also inhibited the progress of the disease and improved the prognosis [134]. In a study with a follow-up for 86 months with 266 HCC patients, Jiedu Granule (JD) combined with TACE prolonged time to progress (TTP) (8.67 vs 5.37 vs 4.57 months) and the median OS (21.43 vs 23.23 vs 13.97 months) compared with TACE alone and TACE plus sorafenib [135] (Additional file 1: Table S4). It followed that the combination of TCM prolonged the PFS and OS, increased the effective rate of IT and improved the adverse reactions of patients with HCC. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273621247590415-1442247797317_Q64/Xiaofeng-Zhai.jpg)
