Heliang Li's research while affiliated with Sun Yat-Sen University and other places

... Although initially described to entrap and disarm pathogens as a part of our innate immune system [9], NETs have been implicated in several non-infectious settings. Increasing evidence has demonstrated a role of NET formation in tumor progression and metastasis [10,11] by facilitating metastatic spread, enhancing angiogenesis and aiding the escape of cancer cells from immune recognition by forming a barrier between cancer cells and the immune system [10,[12][13][14][15][16]. Peptidylarginine deaminase 4 (PAD4) is an enzyme primarily expressed in neutrophils and is involved in the release of NETs by catalyzing histone citrullination, which in turn initiates chromatin decondensation [17,18]. ...

... Bispecific antibodies (BsAbs) refer to the artificial antibodies that specifically bind to two antigens or epitopes at the same time (1). Since 1960, when the concept of bsAbs was first introduced, chemical coupling, two-hybrid tumor fusion, and genetic engineering techniques have been used to prepare bsAbs (2). In recent years, with the gradual maturation of recombinant antibody expression and purification technology in vitro, bsAbs have even shown a clear blowout trend. ...