Hartwig Andree's research while affiliated with Humboldt-Universität zu Berlin and other places
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Publications (4)
The synthesis of the erythroid lipoxygenase, an enzyme which is of importance for the degradation of mitochondria during the maturation of reticulocytes to erythrocytes, was studied in reticulocytes from bone marrow and in density‐separated fractions from peripheral blood of anemic rabbits.
Lipoxygenase mRNA was enriched to about 75% by digestion o...
Peripheral rabbit reticulocytes synthesize at least 30 non-globin proteins. One of them is identified as a characteristic lipoxygenase on the basis of its molecular weight, its immunological properties and its behaviour on an ion-exchange column. The enzyme is not produced in bone marrow cells. The synthesis of the lipoxygenase in peripheral blood...
Citations
... ALOX15 mRNA translation control restricts enzyme synthesis and activity to terminal erythroid maturation. This is critical as ALOX15 activity in premature erythroid cells would disturb their energy metabolism (25,26). Silencing of ALOX15 mRNA translation is mediated by HNRNPK that constitutes an inhibitory complex at the 3'UTR differentiation control element (DICE), in concert with HNRNPE1 and DDX6 (10,16,27,28). ...
... Translation of mRNA is controlled by the large populations of mRNA-specific proteins and miRNAs found associated in the repressed free mRNPs. Furthermore, the early data indicated that a given mRNA can shuttle between the translated and repressed states (as shown e.g. in erythroid cells for lipoxygenase [89] and other mRNAs [76,90,91]), a concept that is now taken for granted [83]. ...
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... Ruling out effects on mRNA stability is necessary but not sufficient. The delayed production of lipoxygenase in differentiating reticulocytes [Thiele et al., 1982] is a classic example wherein a stable mRNA accumulates in the cytoplasm without detectable accumulation of the encoded protein, but the evidence is not sufficient to declare regulation at the level of translation. An alternative possibility—that the protein is synthesized and rapidly degraded in immature cells—has never been examined. ...
