Harpreet Purewal's research while affiliated with Le Moyne College and other places
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Publication (1)
Transcriptional regulation is vital for organismal survival, with many layers and mechanisms collaborating to balance gene expression. One layer of this regulation is genome organization, specifically the clustering of functionally related, co-expressed genes along the chromosomes. Spatial organization allows for position effects to stabilize RNA e...
Citations
... The availability of genome sequences is critical to elucidating the genetic basis of MEL biosynthesis, and the annotated genomes are mined for candidate genes that are potentially involved in MEL biosynthesis. Extensive clustering of functionally co-regulated gene families exists in closely related Basidiomycota fungi and allows for the stabilization of expression patterns [174]. The gene cluster encoding MELs consists of five genes: MAT1, MMF1, MAC1, EMT1, and MAC2 [155,175] (Figure 5). ...
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