Hao Jin's research while affiliated with Shenzhen Children's Hospital and other places
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Publications (10)
N6, 2′-O-dimethyladenosine (m⁶Am) is a widespread RNA modification catalyzed by the methyltransferase PCIF1 (phosphorylated CTD interacting factor 1). Despite its prevalence, the biological functions of m⁶Am in RNA remain largely elusive. Here, we report a critical role of PCIF1-dependent m⁶Am RNA modification in ciliogenesis in RPE-1 cells. Our fi...
N 6,2’-O-dimethyladenosine (m6Am) is a prevalent modification frequently found at the 5’ cap-adjacent adenosine of mRNAs and snRNAs and the internal adenosine of snRNAs. This dynamic and reversible modification is under the regulation of methyltransferases PCIF1 and METTL4, along with the demethylase FTO. m6Am RNA modification plays a crucial role...
Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m ¹ A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological function of m ¹ A modification remains largely unknown. Here we find that the m ¹ A demethylase AL...
N1-methyladenosine (m1A) is a prevalent and reversible post-transcriptional RNA modification that decorates tRNA, rRNA and mRNA. Recent studies based on technical advances in analytical chemistry and high-throughput sequencing methods have revealed the crucial roles of m1A RNA modification in gene regulation and biological processes. In this review...
Epigenetics In their Communication on page 19592, Ye Zhang, Tianhua Zhou, Yang Li et al. report the programmable demethylation of RNA N1‐methyladenosine by a Cas13d‐directed demethylase.
Epigenetik In der Zuschrift auf S. 19744 berichten Ye Zhang, Tianhua Zhou, Yang Li et al. über die programmierbare Demethylierung von RNA‐N1‐Methyladenosin durch eine Cas13d‐gerichtete Demethylase.
N¹‐methyladenosine (m¹A) is a prevalent and reversible RNA modification, which plays a crucial role in the regulation of RNA fate and gene expression. However, the lack of tools to precisely manipulate m¹A sites in specific transcripts has hindered efforts to clarify the association between a specific m¹A‐modified transcript and its phenotypic outc...
A tool for targeted m¹A demethylation of specific cellular RNA without changing the primary sequence, termed „REMOVER“, was developed via combining the RNA-targeting capability of dCasRx (the catalytically inactive RNA-targeting RfxCas13d enzyme) and the RNA m¹A demethylation property of ALKBH3. REMOVER enabled m¹A demethylation of the specific RNA...
Non-coding RNAs (ncRNAs) are functional RNA molecules that play crucial regulatory roles in many fundamental biological processes. The dysregulation of ncRNAs is significantly associated with the progression of human cancers, including gastric cancer. In this review, we have summarized the oncogenic or tumor-suppressive roles and the regulatory mec...
Citations
... First, mRNAs with cap-adjacent m 6 Am modifications were more resistant to decapping by Dcp2, consistent with m 6 Am conferring increased mRNA stability 3 . In contrast, more recent works have shown that the presence of m 6 Am had either little or a negative effect on stability of mRNAs, and the gene expression was also m 6 Am independent [6][7][8] . The likeliest interpretation of these conflicting data is that the function of m 6 Am on mRNAs doesn't follow a single rule. ...
... The m 1 A RNA modification reportedly plays a pivotal role in various functional activities and has recently drawn increasing research attention. Many bioinformatics analyses have suggested that m 1 A-regulating transcripts play essential roles in various cancers (Zhao et al., 2019;Wang et al., 2020;Li et al., 2021;Zheng et al., 2021;Jin et al., 2022;Mao et al., 2022). However, the effects of m 1 A on BLCA remain poorly understood. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272413543890971-1441959858503_Q64/Tianhua-Zhou-2.jpg)
... Control-enrichment was not explained by sequencing methodology, ancestry cluster, or specific phenotype/disease population within the control cohort. Because ALKBH3 plays a role in DNA repair [21], a mechanism increasingly implicated in ALS pathogenesis [22], we attempted to replicate this novel association by analyzing summary statistics from the Project MinE cohort, which is similar in size to ours [23]. None of the available models focused on variation as rare as in our analyses, but at a higher minor allele frequency (MAF) for qualifying variants (0.005), a minor degree of control-enrichment was in fact observed (OR = 0.56, p = 3.96 × 10 -4 ). ...
... To avoid such interference, site-specific manipulation of m 1 A meets the urgent needs of m 1 A methylation study. However, only two programmable m 1 A tools have been reported [38,71] and their usage in functional study remains to be popularized. ...
... Fusing nucleus-or cytoplasm-localized dCas13 with a methyltransferase domain enables site-specific N 6-Methyladenosine (m 6 A) incorporation within distinct cellular compartments [44]. Conversely, RNA modifications such as m 6 A and m 1 A can be removed in site-specific manner by fusing dCas13 with corresponding demethylases, such as ALKBH5 and ALKBH3, respectively [45,46]. Translation of specific mRNAs can be enhanced by dCas13 fused to translation initiation factors such as IF3 in Escherichia coli [47] and PABPC1 in various human cells [48]. ...
Reference: Programmable RNA targeting with CRISPR-Cas13
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1037107636215812-1624277137797_Q64/Yang-Li-77.jpg)
... Circular RNA circNRIP1 acts as a sponge for microRNA-149-5p and promotes gastric cancer progression through the AKT1/mTOR pathway [9]. CircRNAs play a pivotal role in gastric cancer progression and have potential as prognostic markers [10,11]. ...
