Hagen Fritzsche's research while affiliated with Universitätsklinikum Carl Gustav Carus Dresden and other places

Publications (35)

Article
Full-text available
Introduction: Bone sarcoma or direct pelvic carcinoma invasion of the sacrum represent indications for partial or total sacrectomy. The aim was to describe the oncosurgical management and complication profile and to analyze our own outcome results following sacrectomy. Methods: In a retrospective analysis, 27 patients (n = 8/10/9 sarcoma/chordoma/l...
Article
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Simple Summary Giant cell tumor of bone (GCTB) is an osteolytic tumor driven by an H3F3A-mutated mononuclear stromal cell with an accumulation of osteoclastic giant cells. Anti-RANKL antibody therapy with denosumab leads to morphological changes, and sarcomas have been described in association with therapy. We compared tissue from patients with rec...
Article
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Myofibromas are rare benign tumors with myofibroblastic origin. They occur especially in cutis and subcutaneous tissue of the head and the neck, less frequently on the extremities. Myofibromas grow very slowly and are often painless, which is why patients often present relatively late. In the literature, there were many reports about intraosseous m...
Article
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Musculoskeletal tumours of foot or ankle make up about 4–5% of all musculoskeletal tumours. Fortunately, about 80% of them are benign. However, due to the rarity and low prevalence of each single tumour entity, diagnosis is often difficult and delayed. Ultrasonography is an important diagnostic tool to safely recognize ganglion cysts as a frequentl...
Article
Zusammenfassung In den letzten Jahren wurden bedeutsame Daten zur Biologie und Therapie des Riesenzelltumor des Knochens (RZTK) veröffentlicht. Ein entscheidender Durchbruch für die Diagnostik von RZTK war die Entdeckung der hoch tumorcharakteristischen Mutation im H3F3A-Gen, die zum Aminosäureaustausch G34W im Histon H3 führt. Zudem konnte sich in...
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Malignancies with an extended encasement or infiltration of the aorta were previously considered inoperable. This series demonstrates replacement and subsequent resection of the thoracoabdominal aorta and its large branches as an adjunct to curative radical retroperitoneal and spinal tumor resection. Five consecutive patients were enrolled between...
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Background Extensive loss of soft tissue and bone due to neoplasia, trauma, or infection in extremities often leads to amputation. Case presentation We present the case of a 72-year-old female patient presenting with an extended cutaneous squamous cell carcinoma of the lower leg, developed on top of necrobiosis lipoidica. After achieving the R0 re...
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Introduction Malignant diseases with infiltration of bony structures in the area of the phalanges or metacarpals require either amputation or complex reconstruction. The decision for reconstruction means to restore length, mobility, sensibility, stability as well as aesthetics. Methods We present a case of complex first ray reconstruction of the l...
Preprint
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Background: Extensive loss of soft tissue and bone due to neoplasia, trauma or infection in extremities often lead to amputation. Case presentation: We present the case of a 72 year old female patient presenting with an extended cutaneous scquamous cell carcinoma of the lower leg, developed on top of necrobiosis lipoidica. After achieving the R0 re...
Article
Die 97. Arbeitstagung der AG Knochentumoren konnte vom 8. bis 9. Oktober 2021 in Dresden am UniversitätsCentrum für Orthopädie, Unfall- und plastische Chirurgie erstmals wieder als Präsenztagung unter 3G-Regeln bei 7-Tage-Inzidenzwerten von 88 stattfinden.
Article
Background Hip dysplasia belongs to the most frequent hip deformities and is a relevant risk factor for osteoarthritis.Objectives What is the influence of dysplasia on hip osteoarthritis? What is the indication for conservative treatment and surgical intervention?Material and MethodsA literature analysis up to 2021 providing data about the natural...
Article
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Background The “cup-in-cup” technique allows for revision of failed total hip arthroplasty (THA) when the cementless cup is well fixed. Furthermore, it can be used for liner wear or mechanical failure where liner replacement may be impossible or impractical. Recently, the “cup-in-cup” technique in combination with dual mobility cups (DMC) has drawn...
Article
Zusammenfassung Unter den seltenen Primärtumoren des Skelettsystems zählen die chondrogenen zu den am häufigsten auftretenden. Innerhalb des chondroiden Grundmusters, zeigt sich eine große Bandbreite an radiomorphologischen und histopathologischen Erscheinungsformen mit variierender tumor-biologischer Aktivität. An der Wirbelsäule treten diese Tumo...
Preprint
Full-text available
Background: The “cup-in-cup” technique allows for revision of failed total hip arthroplasty (THA) when the cementless cup is well fixed. Furthermore, it can be used for liner wear or mechanical failure where liner replacement may be impossible or impractical. Recently, the “cup-in-cup” technique in combination with dual mobility cups (DMC) has draw...
Chapter
Periazetabuläre Tumoren (Sarkome/Metastasen) haben oftmals schon eine beträchtliche Größe zum Diagnosezeitpunkt und werden erst spät bei pathologischer Fraktur, Gelenkinvasion oder Kompression viszeraler/ neurovaskulärer Strukturen symptomatisch. Die Einteilung der Beckenrresektion erfolgt nach Enneking und Dunham/Typ I-IV). Nachfolgender Artikel b...
Article
Biopsy followed by histopathological assessment is the key procedure to establish the correct diagnosis of unclear bone or soft tissue tumors. There are several possibilities to obtain a biopsy specimen. The indication for biopsy should be established in a specialized center, as should the type of biopsy (fine needle, incisional, excisional, percut...
Article
Background Tumourous destruction of the periacetabular region and the proximal femur is a typical consequence of either primary malignant bone tumour manifestation or skeletal metastatic diseases. Pathological fractures of the proximal femur and periacetabular regions due to primary manifestation or metastatic disorders are frequent.Objectives Pres...
Article
Background Tumor endoprostheses are available as modular systems with which bone defects can be partially reconstructed, usually close to the joints, or as a total replacement of long tubular bones. As a result of continuously improved survival times, they are used with bone tumors, skeletal metastases and, increasingly, in revision arthroplasty....
Article
Zusammenfassung Aufgrund der steigenden Anzahl an Tumorerkrankungen in Deutschland sowie der verlängerten Lebensdauer mit einer malignen Erkrankung sind Folgeerscheinungen wie Skelettmetastasen und pathologische Frakturen eine zunehmende klinische Herausforderung. Dieser Artikel stellt die Stufendiagnostik sowie die Behandlungsmöglichkeiten bei Pat...
Article
Tumours of the foot and ankle constitute about 4–5% of all musculoskeletal tumours with the majority of them being benign. Diagnosis of malignant soft tissue or bone tumours is frequently delayed because of the relatively low prevalence and uncommon presentation at the foot and ankle. Suspicious lesions or lumps should be subjected to CT, MRI and b...
Chapter
Fuß und Sprunggelenksregion sind eine seltene Lokalisation muskuloskelettaler Tumoren. Das Spektrum umfasst benigne, lokal aggressive und maligne Knochen- und Weichteiltumoren. Größere klinische Studien sind daher rar. Klinische Erstmanifestationen sind v. a. unspezifische Schwellungen und Schmerzen. Pathologische Frakturen als Erstsymptom sind nic...
Article
Zusammenfassung Aufgrund optimierter systemischer onkologischer Therapien und deutlich weiterentwickelter chirurgischer Verfahren zur Resektion und Defektrekonstruktion ist eine gesteigerte Lebenserwartung von Patienten mit muskuloskeletalen Tumoren zu verzeichnen. Insbesondere steigt die Inzidenz von skeletalen Metastasen primärer Tumoren mit oste...
Article
Background: Benign bone lesions are much more common than malignant lesions. Some benign bone tumors have a characteristic and typical radiographic appearance, while others are more challenging. Therapy of benign bone tumors differs greatly. While the majority of benign bone tumors do not require surgical therapy, other specific lesions, e. g. ane...
Article
Das distale Femur ist neben dem proximalen Femur und der proximalen Tibia ein Prädilektionsort für die Manifestaion von primär malignen und benignen/aggressiven Knochentumoren [11] der Extremitäten sowie eine Hauptlokalisation für metastatische Destruktionen. Bei malignen Skeletttumoren des distalen Femurs ist eine rasche Einleitung der Diagnostik...

Citations

... The operation time was 502 ± 159 min, and a bifurcated graft (74.7%) and a physician-made pericardium graft (61.3%) were used most frequently. Additional procedures included renal cold perfusion and partial left heart bypass for distal and/or selective perfusion (described previously) [20]. Of 31 additional simultaneous procedures, intestinal resection was most frequent (Table 3). ...
... Чаще всего мягкотканный компонент представлен несвободным паховым лоскутом, а в качестве костной основы используют фрагмент гребня подвздошной кости [17,18,19]. Описаны также единичные случаи кожно-костной реконструкции с применением других кровоснабжаемых сложных комплексов тканей, которые поз воляют восстановить палец путем выполнения одного вмешательства: свободного кожно-костного латерального лоскута плеча [20], островкового кожно-костного комплекса тканей на второй тыльной пястной артерии [21], островкового кожно-костного лоскута предплечья на задней межкостной артерии [22]. ...
... Only 4 cases of large articulation dislocation (5.6 %) and 1 of early IPD of unmentioned etiology (1.4 %) out of 71 implants were described. In addition, Bellova et al. are the only ones that recorded one case of a dissociation at the cementcup interface (33). ...
... In diesen Fällen ist den palliativen Patienten eine tumorendoprothetische Versorgung in zementierter Technik, gegebenenfalls mit langen Schäften und speziellen Abstützpfannen anzubieten. Die Möglichkeit der postoperativen Vollbelastung stellt einen großen Vorteil dieses Versorgungsprinzips dar [3,4,[6][7][8]. ...
... J Wegrzyn et al have described this with a dual mobility cup as it ensures the greatest construct strength. [4][5][6][7][8] Screw removal was performed to avoid the potential problem of a retained screw getting buried in cement in case a further revision is required. The holes of the multihole shell were curetted such as to act as anchoring holes for the cement to increase the fixation strength in contrast to roughening the inside of a smooth shell with a burr as roughening may create particulate debris as described by J Wegrzyn et al, Challagan et al and Boner et al. [4][5][6]9 This technique proves to be particularly beneficial for high-risk or low-demand patients. ...
... All tumours with slightest suspicion of malignancy require histopathological proof by biopsy (2,7,16). To prevent wrong indications and avoidable complications, biopsy must be planned by an interdisciplinary tumour board in a designated tumour centre according to strict oncosurgical guidelines (1,3,4,5,11,18). In case of small and in radiomorphologically benign tumours, this can be conducted as an excisional biopsy (6). ...
... По сравнению с традиционным первичным эндопротезированием тазобедренного сустава результаты установки онкологических эндопротезов с замещением дефекта проксимального конца бедренной кости менее благоприятны. За исключением прогрессирования основного заболевания, чаще всего к повторным операциям ведут инфекционные осложнения, вывихи, асептическое расшатывание ножки эндопротеза [1]. Известно, что при перипротезной инфекции (ППИ) в организме больного формируется как минимум три резервуара микробов: абсцессы в мягких тканях и костном мозге, микробная биопленка на поверхности имплантатов, колонизированные костные канальцы. ...
... On the other hand, these muscles provided superior protection of the prosthesis against dislocation and hip pain during activity. Dislocation is the most prominent complication of tumor prosthesis [17]. In our study, we discovered that the eggshell procedure significantly decreased the incidence of dislocation as well as hip pain which is a characteristic complication of hip arthroplasty. ...
... Tumors at the foot and ankle are rare and constitute about 4%-5% of all musculoskeletal tumors (Rammelt et al., 2020;Ruggieri et al., 2014;Toepfer et al., 2018). Benign lesions occur 200 times more frequently than malignant ones (sarcomas that arise in foot and ankle are only about 1%-2% of all sarcoma), and bone tumors affecting the foot and the ankle constitute approximately 3% of all cases (Rammelt et al., 2020;Ruggieri et al., 2014;Salipas et al., 2014;Temple et al., 2001). ...
... In principle, it is recommended that patients with suspicious lesions are examined and treated in tumour reference centers (1,2). Unplanned surgery often results in the need for more aggressive surgery and/or adjuvant radiotherapy and may adversely affect oncologic and functional outcomes (2,3,4,5). The treatment of benign tumours in the foot and ankle region distinctly differs from that of malignant ones. ...