H.A. Boumann's research while affiliated with Utrecht University and other places
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Publications (2)
Phosphatidylcholine (PC) is a very abundant membrane lipid in most eukaryotes, including yeast. The molecular species profile of PC, i.e. the ensemble of PC molecules with acyl chains differing in number of carbon atoms and double bonds, is important for membrane function. Pathways of PC synthesis and turnover maintain PC homoeostasis and determine...
Phosphatidylcholine (PC) is a very abundant membrane lipid in most eukaryotes, including yeast. The molecular species profile of PC, i.e. the ensemble of PC molecules with acyl chains differing in number of carbon atoms and double bonds, is important for membrane function. Pathways of PC synthesis and turnover maintain PC homoeostasis and determine...
Citations
... The cell membrane is an essential barrier that protects cells from environmental stress [62,63]. Phospholipids constitute the bulk of the membrane lipids, and both the head group and the acyl chain could regulate cell membrane properties [64][65][66]. In this study, we found that genes related to glycerophospholipid metabolism, such as those encoding choline kinase and choline/ethanolamine phosphotransferase, were significantly up-regulated in VdPT1 deletion mutants. ...
... Furthermore, we observed a strong decrease in the unsaturation of PC, while the effect for the remaining major GP was modest (PI) or not observable at all (PE). Therefore it appears that since the membrane properties in later growth phases are largely determined by PC, fine-tuning is achieved by remodeling the acyl chain composition within this particular lipid class [34]. The flexibility is expressed as the variance-to-mean ratio (VMR). ...
