H C CHURCHILL-DAVIDSON's research while affiliated with London Deanery and other places

... Since the early observations of Paton andZaimis (1949,1951) tubocurarine has been known to produce fade of tetanic tension of skeletal muscles in animals. Such fade is also regarded as a characteristic feature of the neuromuscular blockade produced by nondepolarizing drugs in man (Churchill-Davidson and Wise, 1960). ...

... They studied 15 patients of whom only four were truly newborn, and four were over the age of 28 days; five patients had pyloric stenosis, of whom three had a metabolic acidosis. Churchill-Davidson and Wise (1964) also reported that the neonatal neuromuscular response was not different from that of the adult. But their series contained only three patients aged 1, 2, and 3 weeks respectively. ...

... The main aim of postoperative pain management is to decrease a patient's pain to a level which can be tolerated by the patient, with minimal or no associated suffering or distress (1) . It is of utmost importance that the anaesthetic and analgesic technique should be such that it provides optimal conditions for surgery and also reduces postoperative discomfort, morbidity and mortality (2) . ...

... These relationships may be different in small children because of immaturity of the neuromuscular junction. In the absence of muscle relaxants, neuromuscular transmission was shown to be poorly sustained in infants in response to 50-Hz tetanic stimulation (Churchill-Davidson and Wise, 1964) and train-of-four stimulation (Goudsouzian, 1980). Thus, differences in the response to train-of-four stimulation between adults and children have been recognized. ...

... However, when loosing 30% (or more) of the blood volume, symptoms of hypo-volemic shock might develop. In 1953, De Wardener et al. said that if oligaemia is not corrected in such patients they are liable to sudden post-operative hypotension [12]. Stanton and Lyon stressed the importance of adequate replacement of whole blood during and after surgical operations [13]. ...

... The possible mechanism of SIF is due to prejunctional depolarizing action of succinylcholine, resulting in repetitive firing of the motor nerve terminals and antidromic discharges that manifest as uncoordinated muscle contractions [7]. The phenomenon of POM was first noted in 1952 by Churchill-Davidson following injections of succinylcholine due to diffuse uncoordinated contractions of muscle bundles [8]. POM refers to occasional vigor of muscle contractionsthat may give rise to a feeling of muscular stiffness/ pain of (facial, jaw, neck, shoulder, chest, back, trunk, limb/extremities)after consciousness has been regained. ...

... Nearly half of subjects with LEMS have an associated tumour. LEMS was first recognized clinically in association with lung cancer [3]. Approximately 50 to 75% of subjects with LEMS have lung cancer, especially small cell lung cancer (SCLC) [1]. ...

... In the intact animals in this study, HR at 28°C (82.4°F) decreased to half of the prehypothermic values, suggesting that cardiac output could decrease to half of the control level, if stoke volume was maintained (27). Such reductions in cardiac output have elsewhere been reported (4,31). During hypothermia, a body fluid shift to the interstitial space caused by an increase in vascular permeability occurs, resulting in a decrease in intravascular plasma volume (28,29). ...

... The resistance to depolarizing agents and sensitivity to non-depolarizing (competitive) relaxants which occurs in von Recklinghausen's disease differs from that observed in patients with carcinomatous neuropathy (Eaton and Lambert, 1957) who are sensitive to both types of relaxants (Wise, 1962;Rooke et al., 1960). The reaction is rather similar to the response which has been noted in patients with myasthenia gravis (Churchill-Davidson and Richardson, 1953;Baraka et al., 1971), in the newborn (Churchill-Davidson and Wise, 1963Wise, , 1964 and in certain species such as the rat (Zaimis, 1953; Baraka, 1972). Under these conditions, there is resistance to depolarizing drugs and sensitivity to competitive blockers. ...

... The whole body oxygen consumption falls as the body temperature is lowered in all mammalian species (Bigelow et al., 1950b;Woodruff, 1941;Adolph, 1950;Lynn et al., 1954). This is also true of the separate organs and the data on them is discussed elsewhere in this article. ...