Gyeonghwa Kim's research while affiliated with Kyungpook National University and other places
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Publications (25)
Arteriovenous malformations (AVMs) are congenital vascular anomalies with a poor prognosis. AVMs are considered intractable diseases, as there is no established approach for early diagnosis and treatment. Therefore, this study aimed to provide new evidence by analyzing microRNAs (miRNAs) associated with AVM. We present fundamental evidence for the...
The clinical significance of hsa_circ_0004018 and hsa_circ_0003570 in patients with hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) is unclear. We aimed to explore the clinical significance and prognostic utility of these two circular RNAs (circRNAs) in patients with HBV-HCC. Based on 86 paired tissue samples of HCC and adjacent non-HC...
Circular RNAs (CircRNAs) are type of noncoding RNAs without 5’ caps and 3’ tails that has been created by back splicing of mRNA. Recently, circRNAs are identified in many types of cancers, and its function has been elucidated as multiple miRNAs sponge. Hepatocellular carcinoma (HCC) is the most common type of malignancies. The incidence and mortali...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. It lacks sufficient diagnostic and prognostic markers, which leads to a poor prognosis. The survival rate of HCC patients is still low due to its highly metastatic nature. According to recent studies, non-coding RNAs play a vital role in cancer pathogenesi...
Objectives: This study aimed to determine whether GCSB-5 has anti-inflammatory and antinociceptive effects in mice with collagen-induced arthritis (CIA), an animal model of rheumatoid arthritis (RA), and investigate the influence of GCSB-5 on the mitogen-activated protein kinase (MAPK) pathway.
Materials and methods: The experimental animal study w...
Ubiquitin-specific protease 1 (USP1) is a deubiquitinase involved in DNA damage repair by modulating the ubiquitination of major regulators, such as PCNA and FANCD2. Because USP1 is highly expressed in many cancers, dysregulation of USP1 contributes to cancer therapy. However, the role of USP1 and the mechanisms underlying chemotherapy remain uncle...
Circular RNAs (circRNAs) are potential biomarkers owing to their stability, tissue specificity, and abundance. This study aimed to evaluate the clinical significance of hsa_circ_0003570 expression and to investigate its potential as a biomarker in hepatocellular carcinoma (HCC). We evaluated hsa_circ_0003570 expression in 121 HCC tissue samples, it...
Circular RNAs (circRNAs) represent potential biomarkers because of their highly stable structure and robust expression pattern in clinical samples. The aim of this study was to evaluate the expression of a recently identified circRNA, hsa_circ_0005986; determine its clinical significance; and evaluate its potential as a biomarker of hepatocellular...
Adipose tissue and skeletal muscle is associated with non-alcoholic fatty liver disease (NAFLD). This study evaluates the association between body composition and histologic severity in patients with NAFLD. Using the cross-sectional CT images at the level of L3 vertebra and the histologic findings of 178 patients with biopsy-proven NAFLD, we analyz...
Background:
Mac-2 binding protein glycosylation isomer (M2BPGi) has been established as a non-invasive biomarker for liver fibrosis. We evaluated the diagnostic efficacy of M2BPGi compared with those of other liver fibrosis markers in liver fibrosis in non-alcoholic fatty liver disease (NAFLD).
Methods:
We analyzed serum M2BPGi levels in 113 NAF...
The level of long interspersed nuclear element-1 (LINE-1) methylation, representing the global deoxyribonucleic acid methylation level, could contribute to the prognosis of cancer via the activation of oncogenes. This study was performed to evaluate the prognostic implications of LINE-1 hypomethylation in patients with hepatocellular carcinoma (HCC...
(1) Background: Lymph node (LN) status is an indubitable prognostic factor for survival among colon cancer patients. MicroRNAs (miRNAs) have been implicated in the development and progression of many cancers and are potential biomarkers for cancer diagnosis and prognosis. Therefore, we validated candidate biomarkers using circulating miRNAs by anal...
Non-invasive diagnostic markers are needed to ease the diagnosis of non-alcoholic steatohepatitis (NASH) among patients with non-alcoholic fatty liver disease (NAFLD). The long noncoding RNA (lncRNA) LeXis is related to cholesterol metabolism and hepatic steatosis in mice, and its batch genome conversion in humans is TCONS_00016452. Here, we aimed...
Background:
Advanced liver fibrosis is the most important prognostic factor in nonalcoholic fatty liver disease (NAFLD). The long noncoding RNA (lncRNA), growth arrest-specific transcript 5 (GAS5), is associated with the inhibition of liver fibrogenesis, and its levels are decreased in cirrhotic liver.
Methods:
We analyzed 51 patients with NAFLD...
Purpose
We aimed to identify biomarkers of response to preoperative CRT in patients with LARC using comprehensive miRNA analysis.
Methods
This study included 65 rectal cancer specimens and 89 serum samples from patients diagnosed with LARC and treated with preoperative. All specimens were collected before CRT for evaluation of biologic differences...
Exosomal noncoding RNAs (ncRNAs) have unique expression profiles reflecting the characteristics of a tumor, and their role in tumor progression and metastasis is emerging. However, the significance of circulating exosomal ncRNAs in the prognosis of hepatocellular carcinoma (HCC) remains to be elucidated. We therefore determined the prognostic signi...
Aim:
Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC).
Materials & methods:
Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor...
Background and Aim: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, with poor prognosis and high risk of recurrence. Previous studies have shown that various microRNAs (miRNAs) are frequently dysregulated in HCC, which contributes to cancer development and progression. Nonetheless, the regulation mechanism of miRNAs is s...
Background and Aim: Colorectal cancer (CRC) is the third most common cancer worldwide. More than half of the CRC patients have liver metastasis at the time of diagnosis, which is the major cause of cancer-related death in CRC. MicroRNAs (miRNAs) have been identified as modulators of the epithelial-mesenchymal transition (EMT)-mesenchymal to epithel...
Hepatocellular carcinoma (HCC) is a worldwide health problem and it is important to understand the mechanistic roles of the biomolecules involved in its pathogenesis. Long non-coding RNAs (lncRNAs) are frequently and aberrantly expressed in various human cancers and are known to play a role in cancer pathogenesis. The aim of this study was to analy...
Non-coding RNAs (ncRNAs) including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have emerged as novel gene-regulators. The aim of this study was to determine the clinical relevancies of 2 lncRNAs (lncRNA-ATB and MEG3) and 2 miRNAs (miR-21 and miR-31) in hepatocellular carcinoma (HCC). We analyzed clinical specimens from 100 pairs of HCC an...
Background and Aim Hepatocellular carcinoma (HCC) is the fifth most common cancer and the most leading cause of cancer-related death worldwide. Although considerable progress has been made in treatment of HCC, early detection is still highly considered the key to improved survival. Thus, for the earlier diagnosis and accurate prediction of HCC, ide...
Citations
... GCSB-5 has been shown to reduce mechanical allodynia and downregulate neuroglial activity in a rat model of lumbar disc herniation [28,29]. In a recent study, GCSB-5 exhibited an anti-inflammatory and antinociceptive effect on the collagen-induced arthritis of mice [30], ...
... For instance, there is emerging evidence suggesting that USP1 enhances BIRC5 stabilization through ubiquitin, which significantly prevents apoptosis induced by ML323 and TRAIL. 24 Suppression of both Mcl-1 and BIRC5 has been shown to efficiently curtail cell growth and increase drug sensitivity. 25 In the context of OC, studies have indicated that miR-203 targets BIRC5, suppressing OC metastasis. ...
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... Finding effective biomarkers for the treatment of HCC is crucial. Numerous research has demonstrated that circRNAs perform crucial regulatory roles in various cancers [14]. For example, hsa_circ_001783 regulated breast cancer progression through miR-200c-3p, and high levels Each experiment has three biological replicates. ...
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... In addition, circRNA-100338 is able to induce metastasis in hepatocellular carcinoma through enhancing invasiveness and angiogenesis [11]. Moreover, hsa_circ_0005986 is considered as a putative predictor of HCC progression and survival of patients with hepatocellular carcinoma [12]. Furthermore, cir-ITCH is a novel tumor suppressor that regulated the development of colorectal cancer [13]. ...
... The presence of a positive association between NAFLD and sarcopenia was established by a comprehensive Mendelian randomization analysis (MR), which is consistent with previous cross-sectional studies [25][26][27][28] . For instance, a prospective study of 225 Caucasian individuals demonstrated a linear increase in the prevalence of sarcopenia with the severity of liver fibrosis (OR = 2.36, P = 0.01). ...
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... M2BPGi is a serum liver fibrosis biomarker and a glycosylation isomer that is recognized by Wisteria floribunda lectin (also known as WFA[ ?]-M2BP) [57]. This marker is a useful predictor of NAFLD at fibrosis stages C 2 and C 3 [58], is not affected by age, and can be judged by a single cutoff point [59]. In addition, M2BPGi can differentiate patients at high risk for severe fibrosis from a healthy control group [60], and it may be a predictor of hepatocarcinogenesis, though further studies are required [61]. ...
... 55 Hypomethylation of promoters facilitates tumor tissue proliferation, invasion, and migration and serves as an independent prognostic indicator for overall survival and disease progression in liver cancer. 30,54,56 The phenomenon of partial promoter hypomethylation plays a pivotal role in HCC by influencing cell cycle dynamics. For instance, Liu et al have shown that hypomethylation of the Cyclin-D1 (CCND1) promoter, specific to the G1/S phase, enhances the development of HBV-HCC. ...
... The analysis of circulating miRNAs showed that miR-21-5p and miR-133a-3p levels were higher in cancer patients than in controls and performed as good biomarkers for cancer diagnosis. As in the muscle, miR-15b-5p was reduced also in plasma confirming previous observations in colorectal cancer patients 25 and associated with poor prognosis in patients with liver cancer. 26 The pattern of miR-15b-5p expression here observed suggests that its plasma levels could be a good indicator of its expression in the skeletal muscle, although the relevance of circulating miR-15b-5p to cancer-induced muscle wasting is unknown. ...
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... Seven studies identified differentially expressed lncRNAs in serum or liver samples from patients with NASH (Table 1). Park et al. found that plasma LeXis was independently associated with NASH, with acceptable diagnostic performance (AUC = 0.743, sensitivity: 54.3%, and specificity: 100%) [45]. Compared with healthy controls, lncSPARCL1-1:2 was upregulated in NAFLD, simple steatosis, and NASH, and lnc-SPARCL1-1:2 was an independent predictor of NASH. ...
... Сверхэкспрессия GAS5 подавляла активацию первичных ЗКП in vitro и уменьшала накопление коллагена в фиброзных тканях печени in vivo [8]. В то же время имеются данные о том, что уровень экспрессии GAS5 в плазме пациентов с НАЖБП может повышаться или снижаться у пациентов с разной степенью фиброза [9]. ...
