Guillaume Bouguen's research while affiliated with Université de Rennes 2 and other places

... A multicentre, parallel-group, open-labelled RCT with a 52-week follow-up led by Amiot et al showed that combination therapy with infliximab and azathioprine with rapid steroid discontinuation commenced in-hospital was more effective than azathioprine with a standard 8-week tapering regimen to prevent treatment failure. 42 Other monoclonal antibodies used for the treatment of moderate to severe UC in the outpatient setting have not been assessed in a RCT for the treatment of patients hospitalised with UC. The utility of advanced combination therapy (ACT) with an anticytokine approach using a second biologic or novel small-molecule inhibitor is also an avenue worthy of exploration in ASUC given the results of the VEGA trial. ...

... Among those with relapse, however, for retreatment with anti-TNF induced remission in 24 or 29 patients (82.8%) [41], 12 patients (27.3%) required defunctioning surgery and one patient required a proctectomy. The radiological remission of pCD prior to the cessation of anti-TNF had a somewhat more favorable prognosis with only five of the 17 patients (35.3%) relapsing but with a median of 6 months [42]. A more recent meta-analysis of 309 patients from 12 studies by Huinink et al. [42] showed similar outcomes with 75/168 (45%) patients developing a relapse of pCD after the discontinuation of anti-TNF therapy after a median follow up of 11 months [42]. ...

... In the same study, Chojnacki et al. detected mitochondrial fragmentation in DSS-treated mice and colonic tissue from UC patients compared to wild-type mice and healthy controls, suggesting a correlation between mitochondrial fission and inflammation. These results are in line with two other studies associating higher levels of phosphorylated DRP1 and mitochondrial fission with inflammation [44] and mitochondrial fusion with mucosal repair [45]. Another study observed increased gene expression of mitochondrial dynamics proteins (Drp1, Fis1, Opa1, Mfn1 and Mfn2) and higher levels of phosphorylated DRP1 in DSS-treated mice [46], in agreement with previous studies. ...

... 33 Likewise, a recent study from France reported rates of overweight and obesity in 24.1% and 12.2% of patients with IBD. 34 In turn, according to an analysis with a large healthcare database from the USA, bariatric surgery or weight loss medications lowered the risk for developing IBD 35 ; however, a similar study demonstrated the opposite effect. 36 Collectively, these studies indicate that obesity and related comorbidities are on the rise in patients with IBD (as similarly observed in the general population), and that obesity is a risk factor for the development of CD and complications (such as perianal disease). ...

... Though not life-threatening, fatigue severely affects the quality of life (QoL) of infertile women [27]. Despite regional variations in reported incidence [28][29][30][31][32], a recent meta-analysis estimated the global prevalence of general fatigue at 20.4% in adults and 11.7% in minors [33]. Studies from 2011 highlighted that 7-45% of the U.S. population experiences persistent fatigue [34]. ...