Greet Vandenberg's research while affiliated with Université Catholique de Louvain - UCLouvain and other places
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Publications (5)
The aim of this study was to explore the changes evoked by organ culture in the signalling pathways activated by noradrenaline in rat resistance mesenteric artery. Contractile responses and calcium signalling were significantly more sensitive to noradrenaline in arteries cultured for 48-72 h in the absence of growth factors compared to fresh arteri...
Mutations in PKD1 are associated with autosomal dominant polycystic kidney disease (ADPKD), which leads to major cardiovascular complications. We used mice with a heterozygous deletion of Pkd1 (Pkd1+/-) and wild-type (Pkd1+/+) littermates to test whether Pkd1 haploinsufficiency is associated with a vascular phenotype in different age groups. Systol...
The diacylglycerol lipase inhibitor 1,6-bis(cyclohexyloximinocarbonylamino) hexane (RHC-80267) was tested for its effect on acetylcholine-evoked relaxation in rat mesenteric artery. In artery contracted with either noradrenaline or KCl, RHC-80267 (0.1-10 muM) potentiated the relaxation evoked by acetylcholine. The effect of RHC-80267 was not affect...
The present study was aimed at investigating whether, besides its pivotal role in Ca(2+)-independent contraction of smooth muscle, Rho-kinase is involved in the mechanisms underlying the Ca2+ signal activated by noradrenaline in arteries. In rat aorta and mesenteric artery, the Rho-kinase inhibitor Y-27632 (10 microM) completely relaxed the contrac...
Citations
... Culturing rat resistance mesenteric arteries results in decreased mR-NAs expression of TRPC1 and increased expression of TRPC6, changing Ca 2+ entry via these channels. This modifies the Src-dependent increase in the contractile response of the artery to noradrenaline [164]. Also, engagement of α 4 β 1 -integrin to a peptide containing the integrin-binding sequence LDV in a spliced variant of fibronectin induces activation of a SFK in arteriole smooth muscle cells, which in turn opens L-type Ca 2+ channels leading to Ca 2+ influx and vasoconstriction [165]. ...
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... 35 Our results suggest there are BP-independent mechanisms involved in vascular changes observed in patients with ADPKD. Morel et al. 36 recently demonstrated altered intracellular calcium homeostasis in the aortas of animal disease models (PKD1 þ/knockouts), suggesting our findings may be directly related to expression of abnormal polycystin in the vascular smooth muscle. Further, renin-angiotensin-aldosterone system and sympathetic nervous system activation in the kidney as a result of cyst formation may lead to shear stress in the vessel walls which activates inflammatory cascades and endothelial dysfunction. ...
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... Determination of mechanic stretch response of femoral artery and the biochemical analysis of regulatory phosphorylation were performed at steady state, which may not fully match the status of these vessels under dynamic conditions. Given that ROK inhibition by Y27632 might influence Ca 2+ homeostasis 45,46 and thus indirectly decrease MLC 20 -S19 phosphorylation, our results do not exclude a potential activation of this regulatory cascade in pathological increase of spontaneous tone. ...
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... In addition, both RHC80267 and JZL184 have multiple biological effects other than regulating 2-AG level in the brain. RHC80267 inhibit cholinesterase and potentiates cholinergic activities [52]. Although JZL184 increases brain 2-AG level by inhibition of MAGL, it exhibits a lack of selectivity and 2-AG is not the only substrate of MAGL [53]. ...
