Gernot Walter's research while affiliated with University of California, San Diego and other places

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Publications (1)

Role of PP2A in Cancer and Signal Transduction
  • Chapter

December 2003

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4 Citations

Gernot Walter

PP2A plays a critical role in growth control and cancer. Importantly, loss or alteration of PP2A activity is an essential step in the development of human cancer, consistent with the idea that PP2A functions as a tumor suppressor. However, PP2A has many, sometimes seemingly conflicting, functions that are poorly understood. On the one hand, it suppresses cell growth, but on the other it is required for cell-cycle progression. Also, it positively and negatively regulates the MAPK/ERK and Wnt signaling pathways. Other important functions of PP2A are its inhibitory role in the interleukin-3-stimulated JAK2-STAT5 signaling pathway and its involvement in NF-KB signaling, protein kinase B/Akt signahng, and integrin-mediated regulation of Akt and GSKSP. Furthermore, the catalytic subunit of PP2A binds to the alpha-4 protein, a homolog of yeast TAP42 involved in translational control.

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Citations (1)

... Diseases that are known to be associated with CALMs or other skin pigmentary abnormalities often present with mutations in genes implicated in the modulation of the Ras/MAPK pathway (Carvalho et al. 2021;Tajan et al. 2018;Silverstein et al. 2002). PP2A holoenzymes have clearly been shown to regulate this pathway (Silverstein et al. 2002;Letourneux et al. 2006;Ory et al. 2003;Ciccone et al. 2015;Adams et al. 2005;Sieburth et al. 1999;Walter 2003); however, some have shown PP2A to be a key negative regulator of MAPK signaling (Silverstein et al. 2002;Zhou et al. 2002;Alessi et al. 1995;Sonoda et al. 1997;Sontag et al. 1993), while others seem to indicate that it functions as a positive regulator of this kinase cascade (Ory et al. 2003;Adams et al. 2005;Abraham et al. 2000;Kubicek et al. 2002;Jaumot and Hancock 2001;Strack 2002;Dougherty et al. 2005). These discrepancies seem to be due to the complexity of the PP2A holoenzymes' structure, their tissue dependence, and the regulatory subunits involved. ...

Reference:

A pigmentary manifestation associated with PPP2R5D-related neurodevelopmental disorder: a case report and review of literature
Role of PP2A in Cancer and Signal Transduction
  • Citing Chapter

  • December 2003

Gernot Walter