Gege Xiao's research while affiliated with Peking University Third Hospital and other places

Publications (19)

Article
Full-text available
The aim of this work was to compare the prognosis and characteristics of patients with Cytomegalovirus (CMV) infection (CMV+) with those of patients without virus infection (Virus–) undergoing repeat keratoplasty. This prospective propensity score-matched cohort study enrolled patients who underwent repeat keratoplasty for graft failure at the Peki...
Article
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Purpose To summarize the outcomes of corneal sight rehabilitating surgery in Stevens-Johnson syndrome (SJS). Methods This is a retrospective analysis of a consecutive case series. Twenty-four eyes of 18 SJS patients were included in this study. The ocular parameters, surgical procedures, postoperative complications, and additional treatments of th...
Article
Purpose The aim of this study was to evaluate the outcomes of deep anterior lamellar keratoplasty (DALK) and compare it with penetrating keratoplasty (PKP) in keratoconic eyes with Descemet membrane (DM) rupture. Methods In this comparative retrospective case series, 33 keratoconic eyes with a history of hydrops underwent DALK and 27 received PKP....
Article
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Background Deep anterior lamellar keratoplasty (DALK) has gained popularity in cases of corneal thinning and leaking descemetocele. In this study, we introduced an intralamellar tectonic patch graft in addition to conventional DALK procedures to treat frank cornea perforation. Methods This retrospective case series included 13 patients (13 eyes) w...
Preprint
Full-text available
Background Deep anterior lamellar keratoplasty (DALK) has gained popularity in cases of corneal thinning and leaking descemetocele. In this study, we introduced an intralamellar tectonic patch graft in addition to conventional DALK procedures to treat frank cornea perforation. Methods This retrospective case series included 13 patients (13 eyes) w...
Article
Full-text available
Purpose Iridocorneal endothelial (ICE) syndrome is a progressive anterior segment disorder that can be tricky to treat. Keratoplasty is commonly used to treat corneal edema in ICE syndrome. However, glaucoma is an important risk factor affecting graft survival. To address this question, we designed a retrospective cohort study to evaluate the effec...
Article
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Background: The goal of this study is to develop a fully automated segmentation and morphometric parameter estimation system for assessing abnormal corneal endothelial cells (CECs) from LASER in vivo confocal microscopy (IVCM) images. Methods: First, we developed a fully automated deep learning system for assessing abnormal CECs using a previous...
Article
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Background Axenfeld-Rieger syndrome (ARS) is a rare kind of anterior segment dysgenesis (ASD). The most common ocular features of ARS are posterior embryotoxon and iris hypoplasia, while some patients may manifest as corneal opacity and edema. However, the current understanding of how ARS affects the cornea is still incomplete. This study reports a...
Article
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Purpose: To evaluate the outcomes of Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) in corneas > 820 microns in thickness. Methods: This retrospective study included 30 eyes of 30 patients who underwent DSAEK. Endothelial cell destiny (ECD) and corneal thickness were recorded before surgery and at 1 and 12 months postoperatively...
Preprint
Full-text available
Background: Axenfeld-Rieger syndrome (ARS) is a rare kind of anterior segment dysgenesis (ASD). The most common ocular features of ARS are posterior embryotoxon and iris hypoplasia, while some patients may manifest as corneal opacity and edema. However, the current understanding of how ARS affects the cornea is still incomplete. This study reports...
Preprint
Full-text available
Objectives: The present study assessed the risk factors for cytomegalovirus (CMV) corneal infection and compared the odds ratios. Methods: This study was a retrospective case-control study (2014.12–2021.1) over a 6-year period. We reviewed the medical record data and compared the differences between the CMV-positive and virus-negative groups with r...
Article
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Objectives: To determine the relationship between the preoperative degree of corneal edema in the recipient and the endothelial cell density in grafts after Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: This retrospective case series enrolled 111 eyes of 107 patients who underwent DSAEK. The preoperative and postoperati...
Article
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The aim of this study was to investigate the histopathological manifestations of congenital corneal staphyloma accompanied by anterior segment dysgenesis and evaluate the prognosis after penetrating keratoplasty with an ultralarge button graft. We retrospectively studied 8 pediatric patients with large congenital corneal staphylomas in the Departme...
Preprint
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Background To present a newly modified descemetopexy method and investigate the most determinative factor in the prognosis of Descemet’s membrane detachment (DMD). Methods This was a retrospective review of 37 patients (38 eyes) treated with the newly modified descemetopexy method. This surgical method was combined with the vacuum technique to pump...
Article
Background: There is still controversy over the necessity of screening donor corneas for herpes simplex virus (HSV). Currently, no study reported the outcomes of different types of keratoplasty with HSV-positive donor corneas. Objectives: To describe the clinical consequences of four patients who underwent keratoplasty by sharing double corneas...
Article
Purpose: To report an uncommon case in which an insect foreign body (FB) in the cornea induced severe marginal ulcerative keratitis. Methods: The insect body was removed during an eye examination. A shaped deep lamellar keratoplasty was then performed on the ulcerous corneal tissue and pseudopterygium. The insect FB was identified as a member of...
Article
Purpose: To report the long-term outcomes of Descemet stripping endothelial keratoplasty (DSEK) with suture-assisted donor lenticule insertion performed in different age groups for pediatric patients with congenital hereditary endothelial dystrophy (CHED). Design: Retrospective case series. Methods: Pediatric patients with CHED who underwent D...
Article
Full-text available
Background: To compare different K readings in pseudophakic patients post-Descemet's stripping automated endothelial keratoplasty (DSAEK) and evaluate corresponding prediction errors in intraocular lens (IOL) power calculations. Methods: Subjects that underwent cataract surgery and DSAEK surgery at least 3 and 6 months prior, respectively, and I...
Article
To classify the clinical stages of Acanthamoeba keratitis (AK), and clarify the relationship between pathological changes and clinical features. Between January 2007 and May 2012, AK was diagnosed in 11 eyes by pathological examination and confocal laser scanning microscopy. Pathological investigation of all cornea samples from keratoplasty was don...

Citations

... 7 Corneal abnormalities like corneal opacity and edema are some of the atypical features of ARS caused by glaucoma or intraocular surgery in most cases. 8 The ARS can include other complications like craniofacial deformities such as, maxillary hypoplasia, hypertelorism, telecanthus, enlarged sella turcica, and sometimes, cleft palate along with dental and periumbilical abnormalities. 9,10 The key dental features include maxillary hypodontia or oligodontia, microdontia, enamel hypoplasia, taurodontism, conical teeth, short roots, and delay in eruption. ...
... The procedure of choice remains the implantation of drainage devices. Keywords: anterior segment dysgenesis, congenital corneal staphyloma, penetrating keratoplasty, glaucoma, drainage surgery _________________________________________________________________________________________________  ВВЕДЕНИЕ Врожденная стафилома роговицы, или врожденная передняя стафилома, -редкая аномалия развития, характеризующаяся увеличенной в диаметре непрозрачной эктазированной роговицей, выступающей через межпальпебральную щель, в сочетании с выраженным дисгенезом переднего сегмента глазного яблока [1][2][3][4][5]. ...
... HSV-1 seroprevalence among adult non-Hispanic white females and males in the U.S. midwest is less than that in other regions of the U.S. and has decreased in recent years [11]. Third, donor corneal Descemet membrane and endothelium layers used in DMEK have been linked to HSV transmission [9,12,13], and HSV DNA has been detected in pretransplant donor corneas given to DMEK recipients who then developed HSV infection causing graft detachment and corneal edema [9,12,13]. Lastly, our patient's corneal HSV infection was limited to the DMEK graft area at the inner corneal surface where it produced anterior chamber inflammation but not retinitis. ...
... Moreover, pseudopterygium could be caused by a chronic inflammatory process [33][34][35][36] such as chronic cicatrizing conjunctivitis [37][38][39], after an ocular infection due to ocular gonorrhoeae [36], herpesviridae [37], or pseudomonas [38]; due to autoimmune processes such as mucous membrane pemphigoid [12,[39][40][41][42][43][44], epidermolysis bullosa [13,45], erythema multiforme [12], ocular rosacea [35,46], Still disease [18], ocular atopy [11,47], actinic prurigo [48][49][50][51][52][53], ocular psoriasis [54], or erythema elevatum diutinum [55]; and even related to ocular topical drugs [56]. Other less frequent causes with which it has been related would be Goldenhar-Gorlin syndrome [57], xeroderma pigmentosum [58], ocular keloids [59,60] and in conjunctival lymphangiectasia [61] (Figure 3). ...
... In the study conducted by Yang et al., the mean preoperative visual acuity for the CHED group was 1.03 ± 0.25 logMAR, which was better than that observed in our study group. [22] In comparison to reported studies wherein the visual acuities seen in PA and PCG groups were 2.049 ± 0.965 and 0.37 ± 0.48 logMAR, respectively, the visual acuities were decreased in our study groups. [23,24] A higher mean and median IOP was seen in the PCG group as compared to the CHED and PA groups though not statistically significant. ...
... They compared the two devices and reported that SimK (5mm) zone measurement was more reliable in IOL power calculation and gave the lowest MAE value. The only study in the literature about IOL power calculation in corneas that had undergone keratoplasty was performed by Xu et al. [22]. They compared different K readings in pseudophakic patients post-Descemet's stripping automated endothelial keratoplasty (DSAEK) and evaluated corresponding prediction errors in IOL power calculations. ...
... Only 1 (0.6%) case was diagnosed with FK. 33 Neovascularization also becomes a risk factor for VK or outcome after VK. Similar findings that neovascularization was a significant sign of the development stage and convalescence stage were observed in AK. 34 Gurung et al. 35 pointed out recurrent HSV stromal keratitis was associated with neovascularization and a well-defined factor (fibroblast growth factor-2) could drive and maintain progressive corneal neovascularization after HSV-1 infection. As another major portion of the non-FK group, BK always presented an acute onset pattern that VEGF-A would rapidly increase in the early stages of disease (Day 2) and promoted corneal angiogenesis. ...