G. Liang's research while affiliated with University of Texas Southwestern Medical Center and other places
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Publications (2)
After brief starvation, vertebrates maintain blood glucose by releasing fatty acids from adipose tissue. The fatty acids provide energy for gluconeogenesis in liver and are taken up by muscle, sparing glucose. After prolonged starvation, fat stores are depleted, yet blood glucose can be maintained at levels sufficient to preserve life. Using a new...
Citations
... Similarly, glucagon has also been described as an inhibitor of SCD1 transcription, possibly due to a direct inhibition of the insulin-stimulating effects [71]. Deficient insulin signaling contributes to mTOR/AKT downregulation in DM1, which may fail to activate sterol regulatory element binding protein 1c (SREBP-1 C), a direct transcriptional regulator of fatty acids synthesis genes and dependent of [72][73][74] This hypothesis is supported by our results, where we observed that adding an LXR agonist to DM1 cells is sufficient to restore OA levels. Globally, it is likely that defects in the aberrant splicing of INSR contribute to SCD1 downregulation in DM1. ...
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... Ghrelin signaling was first linked to growth hormone secretion and appetite regulation (Müller et al., 2015). In addition it has implications in glucose metabolism, energy homeostasis, and organismal response to starvation (Egido et al., 2002;Reimer et al., 2003;Zhao et al., 2010a;Zhao et al., 2010b;Tong et al., 2010;Goldstein et al., 2011;Heppner et al., 2012;Li et al., 2012;Yada et al., 2014;Gagnon et al., 2015). Less obviously ghrelin signaling has also been implicated in cardio-protection, protection against muscle atrophy, and bone metabolism (Nass et al., 2008;Müller et al., 2015;Pearson et al., 2019;Tokudome and Kangawa, 2019;Agosti et al., 2020;Wu et al., 2020). ...
