Frank McCormick's research while affiliated with UCSF University of California, San Francisco and other places
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Publications (3)
Cutaneous neurofibromas (cNFs) are the most common tumor in people with the rasopathy neurofibromatosis type 1. They number in hundreds or even thousands throughout the body, and currently, there are no effective interventions to prevent or treat these skin tumors. To facilitate the identification of novel and effective therapies, essential studies...
Citations
... (A) Nf1-deficient SCs, the cells of origin for PNF, communicate via paracrine signaling and direct cell-cell contact with multiple Nf1+/-cell types within the tumor field, including neurons, macrophages, T cells, mast cells, fibroblasts, and endothelial cells, influencing neurofibroma pathogenesis. Adapted from Rhodes et al.[89]. (B) Malignant transformation of plexiform and atypical neurofibroma (ANNUBP) precursor lesions is associated with exclusion and/or exhaustion of infiltrating T cells, predominance of M2, pro-tumorigenic macrophages, and a decline in antigen presentation. ...
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