Frank J. Akin's scientific contributions

... Humans and hairless mice have been found to have similar action spectra and time courses when it comes to the acute impact of UV light [25]. According to photoaging research, UV-induced connective tissue damage in humans is largely analogous to that seen in animals (mice) [26]. Many investigations have been conducted since then using the animal photoaging paradigm. ...

... In the veterinary literature, as with humans, several cases of canine cutaneous hemangiomas [10][11][12], canine conjunctival hemangiomas and hemangiosarcomas [13] as well as equine ocular, periocular and vulvar hemangiosarcomas [14,15] were suspected to be linked in some way to UV radiation exposure. The case report described here has already been involved in a recent study of Millanta et al., who dealt with five cases of feline non-epithelial cutaneous tumors with histopathological changes characteristic of chronic solar irradiation and, particularly, with elastosis [16], an important and recognized sign of photodamage [14,[17][18][19][20]. In this paper, we aim to describe in more detail the histopathological features indicative of skin photodamage in the skin adjacent to a bilateral auricular primary fibrosarcoma in a domestic short-hair cat, together with the clinical history and laboratory and imaging diagnostic findings. ...

... Photoaging was considered irreversible for centuries until Kligman et al. found it partially reversible in hairless mice [1]. Since then, efforts have been undertaken to reverse photoaging using retinoic acid and topical/systemic natural antioxidants [2,3]. ...

... In this review, we focus on the various products extracted from the plants camellia sinensis (green tea), andrographis paniculata and curcuma longa (turmeric), which can be used for dermatological purposes, protecting the skin against ageing, against solar UV radiation responsible for cutaneous carcinoma, but also against the cutaneous aggression of anti-cancer treatments and other oxidative stresses [12][13][14][15]. The various active compounds present in these three plants will be detailed, but their major drawback remains their low bioavailability and poor skin penetration, which is why the use of their extracts in cosmetic products has so far been limited despite their interest. ...

... In agreement with our findings, Freund et al. previously demonstrated that loss of lamin B1 preceded the activation of SA-β-gal and SASP 12 . UV-exposed skin is histologically characterized by a prominent thickening of the epidermis 29,30 . Increased epidermal thickening has previously been observed in Lmna knockout mice, and in mice expressing progerin, a mutated form of lamin A that is associated with the premature ageing syndrome progeria [31][32][33] . ...