Ferda Özlü's research while affiliated with Cukurova University and other places
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Publications (67)
BACKGROUND: Delayed cord clamping is the standard of care for both term and preterm infants worldwide. The aim of this study was to evaluate the effect of 60-second or 180-second delayed cord clamping during labor on cerebral oxygenation and cardiac function. METHODS: Healthy newborns were divided into two groups: a 60-second delay in cord clamping...
Purpose: Transport of neonates with critical congenital heart disease (CCHD) necessitates professional and experienced staff and, well-equipped facilities for both the procedure and post-operative care. In this study, we aimed to evaluate the effect of transport on operation time and survival in neonates with CCHD and determine the relationship bet...
Critical congenital heart disease (CCHD) is one of the leading causes of neonatal and infant mortality. We aimed to elucidate the epidemiology, spectrum, and outcome of neonatal CCHD in Türkiye. This was a multicenter epidemiological study of neonates with CCHD conducted from October 2021 to November 2022 at national tertiary health centers. Data f...
Neonatal lupus syndrome (NLS) is a rare disease with dermatological, cardiac, hepatic and hematologic involvement due to placental transfer of anti-Ro/ SSA and anti-La/ SSB antibodies in infants of mothers with autoimmune diseases. Multisystemic involvement is common in infants. Here we present a baby with neonatal lupus syndrome whose mother had S...
Objectives Ischemia-modified albumin (IMA) is a new biochemical marker of ischemia. We aimed to search blood IMA levels in neonates with congenital heart defects.
Study Design During the study period, patients diagnosed with congenital heart disease and newborns with a diagnosis of hyperbilirubinemia as a control group were included in the study. I...
Amaç: Seftriakson yan etkileri nedeniyle yenidoğanda sınırlı kullanıma sahiptir. Yenidoğan enfeksiyonlarında kullanımı ile ilgili sınırlı sayıda çalışma vardır. Bu çalışma ile setriakson alan yenidoğanlarda seftriakson sonrası oluşabilecek yan etkilerin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çukurova Üniversitesi Tıp Fakültesi Balcalı Ha...
Alpers-Huttenlocher syndrome (AHS) is an uncommon autosomal recessive mitochondrial DNA depletion disease. The classic clinical triad of progressive developmental regression, liver degeneration, and seizures helps define the disorder, but a wide range of clinical expressions occur. The most common mutations in childhood have been identified in the...
Yenidoğan yoğun bakım ünitelerinde özellikle prematüre yenidoğanlarda agresif resüsitasyon ve destekleyici önlemler nedeniyle özofagus perforasyonu adı verilen yeni bir komplikasyon ortaya çıkmıştır. Çok sayıda yenidoğan resüsitasyonuna rağmen, iyatrojenik özofagus perforasyonu hala nadirdir
Hiperinsülinemik hipoglisemi (HH), pankreatik β hücrelerinde kan glukozundan bağımsız olarak düzensiz insülin salınımına bağlı gelişir ve tekrarlayıcı hipoglisemiye neden olur (1). Yenidoğan ve süt çocuklarında ısrarlı hipogliseminin en sık sebebidir. Sporadik ve genetik nedenli HH nadir görülürken (insidansı 1/40000) akraba evliliği sık görülen ye...
Intravenous lipid emulsions are commonly used as a part of parenteral nutrition in premature infants. The potential bilirubin-displacing effects of high free fatty acid (FFA) levels during lipid infusions are known. Levels of free bilirubin (FB) predict the risk of bilirubin neurotoxicity more accurately than indirect serum bilirubin levels. In the...
Objective:
Hydroxychloroquine (HCQ) has immunomodulatory, antithrombotic, cardiovascular, antimicrobial, and antineoplastic effects. In this study, we aimed to investigate antiapoptotic and immunomodulator effect of intraperitoneal HCQ in hypoxic-ischemic (HI) injury in newborn rats.
Study design:
Seven to 10 days old Wistar-Albino rats were ran...
Dandy-Walker malformation is a rare congenital malformation, characterized by agenesis or hypoplasia of the cerebellar vermis, cystic dilatation of the 4th ventricle and enlargement of the posterior fossa. Postnatal hydrocephalus develops in approximately 70-90% of the patients. The relationship of Dandy-Walker malformation with postaxial polydacty...
Isolated restrictive foramen ovale (rFO) without complex heart defects is a rare pathology. There may be difficulties in managing this situation, which can lead to right heart enlargement, tricuspid regurgitation and hydrops findings in the foetus. We conducted a retrospective analysis of 8451 foetuses. 7883 (93.2%) had a structurally normal heart...
Konjenital batın ön duvarı defektleri nadir görülen yapısal anomalilerdir. Bu olguların ve eşlik eden anomalilerin erken saptanması, bebeklerin doğumdan sonra yatırılarak izleminin ve bakımlarının erken başlanması prognozu etkilemektedir. Bu çalışma 4 yıllık süre içinde hastanemizde doğmuş ve yenidoğan yoğun bakım ünitemizde takip edilmiş batın ön...
Aim: Premature babies are vulnerable to environmental stress factors mostly in the first weeks of life. During this time, supportive positioning, especially used all-around the baby, makes them feel better as if they are in utero. The aim of the study was to evaluate the effect of supportive positioning on weight gain, vital signs, feeding intolera...
Purpose: Delaying the cord clamping for at least 30 seconds in infants who did not require cardiopulmonary resuscitation after birth has been recommended in the revised guidelines of American Academy of Pediatrics in 2015. We aimed to evaluate the effect of delayed cord clamping on hematological and biochemical parameters, need for hospitalization,...
Congenital hypothyroidism is a significant issue in neonates. A variety of cardiac abnormalities have been described in cases of severe hypothyroidism. It is commonly associated with sinus bradycardia, low QRS complexes, prolonged QT interval and conduction blocks but may rarely cause arrhythmias. Although supraventricular arrhythmias are ordinary...
Amaç: Nozokomiyal sepsis, hastane kaynaklı kazanılmış infeksiyonlar arasında en sık olanıdır. Uygun antibiyotik tedavisine rağmen sepsisin mortalitesi ve morbiditesi hala yüksektir. Bu nedenle diğer tedavi yöntemleri hala aranmaktadır. Yenidoğan yoğun bakım ünitesinde yatan prematüre bebeklerde pentoksifilinin neonatal nozokomiyal sepsisin prognozu...
Amaç: Plasental implantasyon defektleri, antepartum vajinal kanamanın en önemli nedenleridir. Ek olarak, perinatal komplikasyonların insidansı da, özellikle preterm ve gebelik yaşına göre küçük doğan bebeklere bağlı olarak artmaktadır. Yenidoğanlarda diğer komplikasyonlar intrauterin asfiksi, enfeksiyonlar, solunum sıkıntısıdır. Bu çalışmanın amacı...
Amaç: 34 gestasyonel haftadan once doğan bebeklerin annelerine yapılan antenatal magnesiyum sulfatın, bebeklerdeki intraventriküler kanama, beslenme intoleransı, retinopati ya da bronkopulmoner displazi gibi morbiditeler üzerine etkisi henüz tam açıklığa kavuşturulmamıştır. Biz antenatal uygulanan magnezyum sulfatın prematüre bebeklerde erken ve ge...
Background/aim: Systemic to Pulmonary Shunts (SPS) have proven to be highly effective for the palliation of neonates with cyanotic congenital heart disease. Mortality after SPS surgery in neonates has multifactorial basis. We aimed to investigate the clinical results of the SPS in relation to the underlying cardiac disease and to identify the risk...
Midaortik sendrom nadir bir hastalık olup abdominal veya distal inen aortanın segmental veya difüz darlığı ile karakterizedir. Olguların çoğu idiyopatik olmakla birlikte bir kısmı da fibromüsküler displazi, dev hücreli aterit, Moyamoya hastalığı veya nörofibramatozis, Williams’ sendromu ve Alagille sendromu gibi genetik hastalıklara ikincildir. Bur...
Özlü F, Tülüce M, Satar M, Özbarlas N, Kozanoğlu B, Yücel A. Togetherness of Ebstein anomaly and giant hairy nevus in a neonate: first case in the literature. Turk J Pediatr 2018; 60: 744-746. Ebstein anomaly is a congenital heart defect in which the septal and posterior leaflets of the tricuspid valve are displaced through the apex of the right ve...
Background/aim:
Peritoneal dialysis (PD) is generally considered the practical dialysis modality for neonates in the treatment of acute
kidney injury (AKI) and metabolic disturbances. The aim of this study was to evaluate the indications, complications, and outcomes of
PD between January 2011 and December 2016.
Materials and methods:
This study...
Pnömomediastinum mediastene hava girişi ile oluşmaktadır. Çocuklarda genellikle astıma bağlıdır, ancak yenidoğanlarda pnömoni veya mekonyum aspirasyon sendromu predispozan faktörlerdir. Pnömomediastinum tanısı genellikle akciğer grafisi ile konur, yenidoğan bebeklerde pnömomediastinal hava ile kalbin üstündeki timik lopların yukarı ve dışa doğru sa...
Yapıcıoğlu-Yıldızdaş H, Ece Ü, Sucu M, Yurdakul G, Şimşek H, Özlü F. Twin reversed arterial perfusion syndrome in a monochorionic monoamniotic twin pregnancy. Turk J Pediatr 2017; 59: 724-727. Twin reversed arterial perfusion syndrome is mostly seen in monochorionic diamniotic twin pregnancies with an estimated incidence of 1/9500-11000 pregnancies...
The human major histocompatibility complex class I chain-related gene A and B (MICA and MICB) is one of the genes in chromosome 6. As MIC expression is inducible by heat, viral infection, inflammation and DNA damage, the molecules have been thought to be stress markers for the cells. We aimed to find the level of mRNA concentrations of MICA and MIC...
Amaç: Bu çalışmanın amacı prematüre bebeklerde beslenme intoleransı ve ağırlık artışı üzerine Bifidobakteryum laktis ve Hindiba inülini’nin etkisinin değerlendirilmesidir. Gereç ve Yöntem: Beslenme intoleransı tanısıyla izlenmekte olan 89 prematüre bebek bu çalışmaya alınmıştır. Çalışma grubundaki olgulara Bifidobakteriyum laktis (5x109 CFU) + Hind...
Mid-aortic syndrome, a very rare condition is coarctation of abdominal aorta. It is also named as Mid-aortic dysplastic syndrome. It is characterised by segmental or generalised narrowing of either distal decending thorasic aorta or abdominal part of aorta. Some cases can be treated with transcatheteric placed stents.
40 days old infant admitted be...
Akçalı M, Yapıcıoğlu H, Akay E, Özlü F, Kozanoğlu B, Erdoğan K, Gönlüşen G, Satar M. A congenital soft tissue Ewing sarcoma in a newborn patient. Turk J Pediatr 2017; 59: 76-79. < p < Congenital Ewing sarcoma is extremely rare. Here we present a newborn baby born with a mass on the left shoulder. Immunohistochemical staining showed congenital Ewing...
Neuroenteric cysts are rare congenital lesions and they appear due to defect in leaving of notocord from foregut. A definitive diagnosis is made by histopathological examination. Here is a case of a neonate with neuroenteric cyst that is presented by both the thoracic and spinal canal component. Spinal canal component of the neuroenteric cysts must...
Because of the increase in ceserean section, assited fertilization and multiple births, late preterem births was suspected to be increased. We aimed to investigate the incidence of late preterm births in our hospital and evaluate their postnatal medical problems in this study. Late premature infants born alive between 340/7- 366/7 pregnancy weeks b...
Umbilical venous catheterization is frequently used for treatment, monitorization, blood sampling and total parenteral nutrition in neonatal intensive care units. During umbilical catheterization, complications such as occlusion, bleeding, breaking, leaking, thrombosis, infection, distal embolization, perforation and cardiac tamponade may be observ...
Two newborn babies with generalized arterial calcification of infancy, two new mutations. Idiopathic generalized arterial calcification of infancy-1 (GACI-1) is a rare and potentially lethal disease characterized by diffuse calcification of large and medium-sized arteries such as aorta, renal, pulmonary, cerebral and mesenteric arteries. Here we re...
Purpose: The aim of this study is to determine risk factors associated with delayed regression of retinopathy of prematurity and prolonged vascular completion in patients not requiring treatment. Material and Methods: Patients with acute retinopathy of prematurity not requiring treatment were grouped as control and delayed vascularization groups, o...
Prune Belly syndrome (PBS), comprises a triad of anomalies that include abdominal wall flaccidity, urologic anomalies and bilateral cryptorchidism in males. The abdominal musculature hypoplasia predisposes to respiratory problems, respiratory infections secondary to impaired cough mechanism, and cause chronic constipation secondary to ineffective v...
In newborns, hyperammonemia leads to encephalopathy which is usually characterized by vomiting, hypotonia, lethargy, seizures and coma. Continuous venovenous hemodiafiltration (CVVHDF) is a modality choice to treat acute decompensation in hyperammonemia. Here we report three newborn patients with hypotonia, convulsion and hyperammonaemia. In the fi...
Objective
In this study, we aimed to evaluate some laboratory and clinical factors in the prediction of latency period for pregnant patients complicated with preterm premature rupture of the membranes.
Materials and Methods
Sixty-five pregnant patients between 24 and 34 weeks of gestation, who were admitted to University of Çukurova School of Medi...
In this study, newborns with congenital heart disease in the Cukurova University Neonatal Intensive Care Unit during 2007-2011 have been retrospectively evaluated. The incidence of congenital heart disease in newborn babies admitted to the NICU in the 5 years studied was 6.6% (217/3287 patients). 133 (61.3%) of the patients were cyanotic; 76 (35.1%...
Necrotising enterocolitis (NEC), an important disease of the gastrointestinal system in neonatal period, is characterised by total or partial ischemia of the intestines. Although most of the affected neonates are premature, 10% of the patients are term neonates. Here we present three term neonates who were operated due to Grade 3 NEC during their f...
Purpose: to investigate if there were a correlation between blood gas measurements and if we could predict arterial (A) values from capillary (C) or venous (V) measurements in premature infants. Material and Methods:Premature infants with umbilical artery and venous catheters in Newborn Intensive Care Unit were enrolled in to the study. Umbilical a...
The coincidence of necrotizing enterocolitis and rotavirus infections and potentional associations with cytokines. Can J Infect Dis Med Microbiol 2012;23(4):e10303-e105. BACKgrounD: Necrotizing enterocolitis (NEC) is the most com-mon gastrointestinal disease in neonatal intensive care units. Although the pathogenesis of NEC remains unclear, evidenc...
Yenidoğan döneminde mediyastinal enterik kist nadiren görülür. Çoğunlukla bulgu vermez. En sık solunum güçlüğü ile kendini belli eder. Mediyastinal kist omuz anomalilerinin eşlik ettiği bir durumdur ve enterik özellik gösterir. Tanısı esas olarak histolojik bulgularla konulur. Bu yazıda doğum öncesi ultrasonografik incelemede akciğerde kistik adeno...
Background: Transient tachypnea of neonate (TTN) and respiratory distress syndrome (RDS) of the newborn are the most common cause of early respiratory distress in the immediate neonatal period. There is increasing evidence to support the role for the activation of the renin angiotensin system during acute lung injury. Objectives: The purpose of thi...
Double trisomy may occur as autosomal with sex chromosome trisomy or double autosomal trisomy. This coincidence is very rare. Trisomy 18, that is first recognized as a specific entity in 1960 by discovery of the extra 18 chromosome, is characterized by intrauterine growth retardation, prominent occiput, micrognathia, rocker-bottom feet. Klinefelter...
Transient Tacypnea of Neonate (TTN) and Respiratory Distress Syndrome (RDS) are the most common causes of respiratory distress in early neonatal period. The pathogenesis of TTN is still not well understood and is thought to be due to inadequate clearance of fetal lung fluid. In last decades, the evidence of the role of renin-aldostrene-angiotensin...
Fragile X syndrome is a genetic disorder with a semidominance of X chromosome due to mutation in fragile X mental retardation-1 gen (familial mental retardation-1 or FMR-1) which is characterized by learning, linguistic and memory problems due to temporal lobe dysfunction. Fragile X syndrome is the second common cause of mental retardation after Do...
Aseptic menengitis occur due to many aetiologies, mostly viruses. Enteroviruses are responsible more than 80% of the cases. The other frequent aetiologies are arboviruses and mumps viruses. Aseptic menengitis may be the only sign of mumps. Leptospirosis, mycobacterium and cryptococcosus may be enumerated among other aetiologies of aseptic menengiti...
Down syndrome is a genetic disorder with an excess genetic material on 21th chromosome, mild mental retardation and anomalies of multiple organ systems. Physical and neurophysicological findings such as mental retardation, linguistic and memory problems accompany this syndrome. Neuroanatomical origins of this cognitive dysfunctions are not clear ye...
In recent years, there are many studies on serum procalcitonin (PCT) levels, a characteristic test in systemic inflammatory response. There are many studies not only suggesting the usefulness of procalcitonin measurement in diagnosis of severe bacterial infections, but also reporting increase of procalcitonin in systemic inflammation such as severe...
Bacterial menengitis is described as occurence of bacteria in cerebrospinal fluid. Prognosis of bacterial meningitis in dependent on many factors such as the age of patient, period of illness before start of therapy, dansity of bacterial products or number of colony is cerebrospinal fluid at the time of diagnosis, inflamatory response of the patien...
In the last 30 years, some evidence about the release of some factors other than immunoglobulins from the immune system cells which play an important role between cell interactions are found. The factors that release proteinous substances from immun system cells are called "cytokines" and cytokines are effective in each step of inflammation and imm...
Perinatal arrythmia is described as abnormal heart rates or existence of extrasystoles in the fetal or neonatal period. In this study, neonates admitted to the Çukurova University Neonatal Intensive Care Unit between 1 January 1998-30 June 2003 for arrythmia or who were diagnosed as arrythmia after hospitalization were evaluated retrospectively. In...
The most common form of RSV infections in lower respiratory tract is pneumonia and then bronchiolitis. Children under 1 years are more susceptible for RSV infections. Clinical symptoms are atypical under 3 weeks of age and symptoms of upper respiratory tract, lethargy, irritability and feeding intolerance are predominant. After 2-8 days of incubati...
Bartter Syndrome, is characterized by hypokalemic metabolic alkalozis, increased renin and aldosterone levels in spite of normal blood pressure with unknown aetiology. Here we report a 5 month old boy admitting with growth retardation and vomiting, diagnosed as Bartter Syndrome in associaion with craniosnostasis and microcephaly.
Respiratory distress caused by surfactant deficiency and global immaturity of lungs is called "respiratory distress syndrome". Hyaline membrane disease is a pathologic diagnosis characterized by hyaline membrane formation due to alveolar injury and exudation which are caused by surfactant deficiency. All the infants, born before 28 weeks of gestati...
Seckel syndrome, an autosomal recessive syndrome is characterised by microcephaly, dwarfism-prenatal onset growth deficiency, prominent nose, bird- like narrow face, micrognathia, severe mental retardation, chromosomal instability, pancytopenia. Incidence is 1:10000. Here an uncommon case with Seckel Syndrome was reported.
Many factors have a role in the etiology of necrotising enterocolitis whose pathogenesis is not understood yet. Prematurity, hypoxia, enteral feeding and bacterial colonization in guts have played a role in the etiopathogenesis. Because of the occurence of epidemias of necrotising enterocolitis, infectious causes are also accused. Intestinal ischem...
Citations
... Although such advances improve survival in infants with CCHD, the mortality rate remains relatively high [8,10,[14][15][16][17][18]. Although there have been few local studies conducted in Turkey that reported high mortality rates for CCHD [19][20][21][22], there is currently no comprehensive national-level study evaluating CCHD mortality and related conditions. The aim of this study was to examine the prevalence and characteristics of infant mortality attributed to CCHD and to provide evidence for future preventive strategies. ...
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... Based on the previous study, premature neonates who received nesting care achieved more stable temperature and oxygen saturation, less crying, and more sleeping time than those who did not [26]. Consistent with our study, an experimental study from Turkey found that premature neonates who received nesting care achieved higher oxygen saturation and lower pain levels than those who did not [27]. Our study adds to the previous three studies that nesting care would positively affect the heart rate of premature neonates. ...
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... 3 In India, the reproductive and child health programme aims at providing at least three antenatal checkups which should include a weight and blood pressure check, abdominal examination against tetanus and iron and folic acid prophylaxis, as well as anaemia management. 4 The National maternity benefit scheme has been modified by Janani Suraksha Yojana (JSY). It was launched on 12 th April 2005. ...
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... To the best of our knowledge, the diagnosis of acardia is almost always made in the second [17][18][19][20][21][22][23] or third trimester [24][25][26] of gestation by means of transabdominal ultrasound. In some cases, the existence of the TRAP Sequence could even remain unknown until delivery [27,28], when the childbirth is preceded or followed by ambiguous amorph mass expulsion. ...
... Ewing sarcoma (ES) is the second most common malignant bone tumor in children and adolescents, however, it is rarely seen in infants (<12 months of age) and prognosis is controversial in this age group. 1 Some studies showed inferior outcomes compared to older patients, while others showed similar results. [2][3][4][5][6][7][8] The standard treatment for ES includes systemic chemotherapy, surgery and/or radiotherapy (RT). Given the rarity of ES in infants, there are no standard recommendations for treatment. ...
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... And these studies have been shown to be particularly useful in the treatment of acute viral gastroenteritis [3, 10-13, 15, 19, 21]. Although there have been many clinical studies on the probiotics in the prevention and treatment of acute diarrhea, the type, dose, and duration of the probiotics used in these studies differ [11,12,19,[20][21][22][23][24]. The efficacy of the majority of probiotics used in the prevention and treatment of childhood diarrhea varies depending on the strain and dose. ...
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... Generalized arterial calcification of infancy is a rare autosomal recessive disorder characterized by congenital calcification of large and medium sized arteries. The calcification of arterial structures is initiated in the internal elastic lamina and extends into the intima and media, being accompanied by fibrous thickening of the intima, which causes luminal narrowing (17). There are two forms of GACI. ...
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... In the intrauterine period, the development of the heart and related vessels takes place between the 14th and 60th days of CHD. Therefore, disorders related to structural anomalies of the heart pose a risk in this period (2). ...
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... Bununla birlikte klinik olarak en ağır tablolar da bu dönemde geçirilen T. gondii enfeksiyonlarında ortaya çıkmaktadır (5,6). Konjenital toksoplazmoz enfeksiyonu ile doğan bebeklerde intrakraniyal kalsifikasyonlar, hidrosefali, asit, hepatosplenomegali, perikardiyal veya plevral efüzyonlar, hidrops fetalis, motor ve işitme bozuklukları, koriyoretinit gibi, ciddi ve ölümcül olabilen sekeller gelişebilmektedir (7,8 ...
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... Urologists must therefore determine whether to carry out the procedures in a single comprehensive approach or in many steps, as well as take into account the future repair of the abdominal wall flaccidity and urinary tract anomalies, as well as the required correction of cryptorchidism. 2 ...
Reference: A review on prune belly syndrome
