Fen Yun's research while affiliated with Inner Mongolia Medical University and other places
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Publications (9)
In recent years, the incidence and mortality rates of lymphoma have gradually increased worldwide. Tumorigenesis and drug resistance are closely related to intracellular inflammatory pathways in lymphoma. Therefore, understanding the biological role of inflammatory pathways and their abnormal activation in relation to the development of lymphoma an...
Background
The diagnostic utility of SRY-box transcription factor 10 (SOX10) expression in basal-like breast cancer (BLBC) has been reported previously. However, the effect of SOX10 on the malignancy of BLBC cells and the underlying molecular mechanisms remain unelucidated. Here, we investigate the regulatory mechanisms and roles of SOX10 in BLBC p...
Background:
Breast cancer (BRCA) is the most common malignant tumor in the world. Because of its substantial heterogeneity, its clinical treatment is faced with various problems. Only a small number of patients can benefit from the treatment of immune checkpoint inhibitor (ICI). Costimulatory molecule signature (CMS) plays an essential role in T c...
The effects of XCHD on the proliferation of C6 cells and on factors associated with the microRNA-34a (miR-34a)/p53/caspase-3 signaling pathway in vitro were investigated. Methods. XCHD was purchased too much to complete the study. CCK-8 assay was used to measure the XCHD concentration, and qPCR was used to quantify miR-34a expression at the mRNA le...
To reveal novel lncRNAs and explore how could lncRNA affect the ER/PR positive type breast cancer, 16 different lncRNA transcriptomes (8 breast cancer tissues and 8 normal breast tissues) were successfully sequenced. In total, 8,954 high quality lncRNAs, including 5,516 lncRNAs reported in the previous studies and 3,438 novel lncRNAs, were annotate...
Background:
Exploration of the genes with abnormal expression during the development of breast cancer is essential to provide a deeper understanding of the mechanisms involved. Transcriptome sequencing and bioinformatics analysis of invasive ductal carcinoma and paracancerous tissues from the same patient were performed to identify the key genes a...
Objective: To investigate the expression of hypoxia-inducible factor-2α (HIF-2α) in non-small cell lung cancer (NSCLC) tissue, and to analyze its relationships with angiogenesis, cell proliferation and chemotherapy resistance. Methods: Total 112 cases of NSCLC and 20 cases of normal lung tissues were selected, immunohistochemical method was used to...
Epithelial-mesenchymal transition (EMT) is associated with altered connection and junctions between cells and changes in abilities of invasion and migration. In this study, we investigated whether SK-BR-3 breast cancer cells induced to undergo EMT exhibit changes in morphological and invasion abilities after Transforming growth factor β1 (TGF-β1) t...
A high frequency of mutations at the PTEN locus has been noticed in carcinoma of lung. However, the role of PTEN alternations and its association with outcome variables in the genesis of lung carcinoma are not understood fully. The purpose of our study was to examine the impact of EGFR, TGF-α, P-AKT and PTEN in the genesis of non-small cell lung ca...
Citations
... Table S18). For example, MGFRassigned Her2 + subtype marker DN6969C1G3I1 overlaps an annotated gene (ENSG00000244468) previously listed as one of the most highly expressed lncRNAs in breast cancer (69). ...
... Moreover, CST2 is a valuable non-invasive indicator of early recurrence and medical refractoriness in chronic rhinosinusitis with nasal polyps, offering potential benefits in disease prediction and guiding personalised treatment approaches (Mueller et al. 2019). Furthermore, as an oncogene, CST2 plays multiple roles in a diverse range of malignant tumours, potentially contributing to both diagnosis and prognosis (Bao et al. 2019, Cheng et al. 2019, Liu et al. 2018, Wang et al. 2017. The present study found that colorectal cancer tissues had higher CST2 mRNA expression compared to normal tissues based on online databases (Xie et al. 2021). ...
... EMT can occur when E-cadherin and some cytokeratins (epithelial markers) are lost, while the expression of other mesenchymal markers like vimentin and N-cadherin increase (Mani et al., 2008;Taube et al., 2010). Bone morphogenetic proteins, transforming growth factor beta (TGF-β), and diverse transcription factors (Slug,Twist,FOXC1,FOXC2,Snail,Zeb1,and Zeb2) can activate EMT (Taube et al., 2010;Jia et al., 2014;Naka, 2015). ...
... Phosphatase and tensin homolog deleted on chromosome ten (PTEN), encoding the classical PTEN protein with phosphatase activity, acts as a tumor suppressor by antagonizing the activity of tyrosine kinases and other phosphorylases. Meta-analyses indicate a correlation between PTEN and poor prognosis in lung cancer [51], and clinical studies confirm abnormal expression of EGFR, TGF-α, P-AKT, and PTEN in NSCLC patients [52], potentially contributing to NSCLC pathogenesis. ...
