Fanshuo Yin's research while affiliated with Harbin Medical University and other places
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Publications (10)
Arsenic is a toxic metal-like element. The toxic reaction of the body to arsenic is related to the ability of arsenic methylation metabolism. As the rate-limiting enzyme of arsenic methylation metabolism, the genetic single nucleotide polymorphisms (SNPs) of arsenic (+ 3 oxidation state) methyltransferase (AS3MT) gene are related to capacity of ars...
This study aimed to investigate the potential role of pyruvate kinase M2 (PKM2) and extracellular regulated protein kinase (ERK) in arsenic-induced cell proliferation. L-02 cells were treated with 0.2 and 0.4 μmol/L As3+, glycolysis inhibitor (2-deoxy-D-glucose,2-DG), ERK inhibitor [1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene, U012...
Arsenic is a known human carcinogen. Low doses of arsenic can induce cell proliferation, but the mechanism remains elusive. Aerobic glycolysis, also known as the Warburg effect, is one of the characteristics of tumour cells and rapidly proliferating cells. P53 is a tumour suppressor gene that has been shown to be a negative regulator of aerobic gly...
To investigate the potential association between LRP5 rs648438 polymorphism and the risk of skeletal fluorosis (SF) was evaluated in a cross-sectional case–control study conducted in Shanxi, China, in 2019. A total of 973 individuals were enrolled in this study, in which cases and controls were 346 and 627, respectively. SF was diagnosed according...
Arsenic has been identified as a carcinogen, although the molecular mechanism underlying itscarcinogenesis has not been fully elucidated. To date, only a few studies have attempted to confirm a direct link between oxidative stress and the Warburg effect . This study demonstrated that 0.2 μmol/L As³⁺ induced the Warburg effect to contribute to abnor...
Type 2 diabetes mellitus (T2DM) is one of the major public health problems worldwide; both genetic and environmental factors are its risk factors. Arsenic, an environmental pollutant, might be a risk factor for T2DM, but the association of low-to-moderate level arsenic exposure with the risk of T2DM is still inconsistent. Single nucleotide polymorp...
Arsenic is an identified carcinogen for humans.In this study, chronic exposure of human hepatocyte L-02 to low-doses of inorganic arsenic caused cell malignant proliferation. Meanwhile, compared with normal L-02 cells, arsenic-transformed malignant cells, L-02-As displayed more ROS and significantly higher Cyclin D1 expression as well as aerobic gl...
Background
The kidney toxicity of fluoride exposure has been demonstrated in animal studies, and a few studies have reported kidney function injury in children with fluoride exposure. However, epidemiological information for the effects of long-term fluoride exposure on adult kidney function remains limited.
Methods
We conducted a cross-sectional...
The change of serum soluble Klotho (sKlotho) content is related to a variety of osteoarthropathy. However, its association with the severity of skeletal fluorosis (SF) is not clear. Here, the association of tea fluoride exposure with serum sKlotho levels and the severity of SF were investigated and further verified in a rat model of fluorosis. A cr...
To evaluate the association between ALOX15 gene polymorphism and skeletal fluorosis (SF), a case-control study was conducted. A total of 1023 individuals, including 308 Tibetans, 290 Kazaks and 425 Han, were enrolled in this study, in which cases and controls were 278 and 745, respectively. SF was diagnosed by X-ray absorptiometry. SNPs were genoty...
Citations
... In humans, efficient methylation from iAs to DMA is associated with reduced responsiveness and increased urinary arsenic excretion [25]. The extent of DMA methylation is different within and between individuals and populations, suggesting a genetic component to arsenic metabolism [26]. In general, high fractions of MMA and residual non-methylated inorganic arsenic in urine are associated with a higher risk of arsenic-related adverse health effects, suggesting that more efficient arsenic metabolism capacity (a high proportion of DMA) protects the body against arsenic toxicity [27,28]. ...
... Research has shown that exposure to arsenic leads to activation of apoptotic cascades and p53 signaling pathway [28,29]. Here, RNA sequencing analysis indicated activation of the p53 signaling pathway in Nalm-6 cells after treatment with As 4 S 4 (Fig. 1G). ...
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... According to the diagnostic criteria of fluorosis, refer to the "Diagnostic Criteria of Endemic Skeletal Fluorosis" (WS 192-2008) [S] [16]: the group was based on the reference value range of serum fluoride and urinary fluoride reported in the local census. ...
... Arsenic is a heavy metalloid that does not play any role in human physiology and can have harmful effects on the body. The prolonged exposure to elevated levels of arsenic is linked to a higher prevalence of type 2 diabetes [13][14][15][16]. Because, extended exposure to arsenic is linked with insulin resistance and compromised glucose tolerance, both of which are recognized characteristics of the condition. ...
... Fluoride metabolism is pH dependent and involves absorption in the gastrointestinal tract and subsequent renal excretion (Whitford and Pashley 1984;Messer and Ophaug 1993). While low doses of fluoride have a preventive effect on dental health, excessive fluoride consumption has been associated with hepatorenal toxicities (Wei et al. 2014;Wu et al. 2021). The kidneys accumulate the highest fluoride levels in the body, followed by the liver (Malin et al. 2019). ...
... After 24 weeks of feeding, thoracic aortas were obtained and fixed with 10% methanal for pathological examination. Urine of rats was measured by fluoride ion selective electrode method [22] to reflect fluoride exposure in rats. All animal procedures were approved by the Animal Care and Use Committee of Harbin Medical University, Harbin, China (NO. ...
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... Drinking tea with a normal concentration of F is considered somewhat to be safe and even beneficial to health (Guo et al. 2020). However, long-term high consumption of tea made from older leaves (e.g., dark tea) could lead to tea-drinking fluorosis, such as dental fluorosis and bone fluorosis, which has been identified as one of the endemic species of fluorosis in the western minority areas of China Kabir et al. 2020;Chu et al. 2021). Additionally, too much tea F content could affect the tea plant's growth and the taste and aroma of tea leaves Cai et al. 2016). ...
