Fan Yang's research while affiliated with Huazhong University of Science and Technology and other places

... On the other hand, biomaterial-based engineered nanoparticles can also cross the blood-brain barrier, realize target delivery of miRNAs to certain organs and cells, and sustain the release of miRNAs (Lee et al., 2019). miR-124-3p-loaded nanoparticles coated by a modified stem cell membrane could cross the damaged BSCB, accumulate in the lesion area, and release sufficient miRNAs to modulate the local microenvironment and promote axon outgrowth after SCI (Fan et al., 2024). In addition, nanoparticles can be modified with certain peptides or antibodies to target specific cells in the lesion microenvironment. ...

... From early AI applications to the current sophisticated language models, the progression in healthcare technology is noteworthy. Initial AI implementations laid the groundwork for more advanced machine learning and natural language processing (NLP) applications [1,2]. Today, models like ChatGPT, Gemini Advanced, and Co-pilot represent the forefront of NLP, with their advanced text comprehension and generation capabilities crucial for medical literature analysis and improving patient communications [3,4]. ...

... The tumor nodule from patient HCC-5 in the original dataset was cut into four parts for Visium sequencing, and we focus on section HCC-5C in our analysis. We used the HCCDB-SC3 dataset from HCCDB v2.0 [25] as scRNA-seq reference for deconvolution, which was obtained from seven tumor samples and three tumor-adjacent liver tissues in seven HCC patients. The scRNA-seq reference data consist of 61,370 cells from 16 cell types. ...

... L. vannamei is an important economic breeding species cultivated in Ecuador and other South American countries (Duan et al., 2017). According to the China Fishery Statistical Yearbook, L. vannamei has become one of the shrimp species that is cultivated most extensively in China due to its rapid growth, strong resistance to stress, and good economic benefits (Chen et al., 2023). Most research on L. vannamei has mainly focused on genetic breeding (Ye et al., 2023), feed nutrition (Ye et al., 2023) and disease resistance (Xing et al., 2023). ...

... Phylogenetic analysis revealed (I, II, III, IV, V, and VI), which is consistent with the findings of previous studies [25]. The network clustering method has been applied to decipher evolutionary relationships in several gene families, such as the evolution of the SOT gene family in angiosperms, the ARF gene family in plants, and the lineage-specific evolution of MADS-box [55][56][57]. The result of network clustering analysis shows that there are six major clusters of 1785 LACS family genes, which is consistent with the result of phylogenetic tree. ...

... 42 This observation further emphasizes specific oscillatory signatures of tinnitus patient 43 subtypes related to the ability to induce short-term tinnitus suppression via acoustic 44 stimulation. Currently, there seems to be convergence regarding the role of alpha in 45 BATS with most studies reporting an increase while in other frequency bands, especially 46 gamma, the results are diverging and partly contradicting. 47 To the best of our knowledge, no former study attempted to predict tinnitus 48 suppression, 'off-states', or specifically BATS from (naive) resting state M/EEG data. ...

... Bone defects caused by traffic accidents, bone tumors, or specific diseases (such as chronic inflammation and necrosis) impose significant physical and psychological challenges on patients [1][2][3]. Reconstruction and repair of critical bone defects remain challenging, particularly in cases of deep bone defects with irregular shapes [4,5]. Autologous bone grafting is currently the gold standard for bone repair [6]. ...

... To alleviate this hurdle, several online platforms have emerged to streamline the showcase and exploration of spatial transcriptomic data from various sequencing platforms. Two noteworthy databases, Spatial Omics DataBase (SODB) [174] and Spatial TranscriptOmics DataBase (STOmicsDB) [175] stand out in providing comprehensive resources. In the realm of spatial omics, SODB is a pivotal online platform meticulously designed to provide researchers with an extensive collection of data resources and diverse interactive modules for sophisticated data analysis. ...

... Another study used drug nodes or target protein nodes connected by hyperedges based on their similarity in interactions or associations [100]. Lastly, several studies used kNN or learnable hyperedges to construct hypergraphs [73,95,107]. ...

... Recently, multiple large-scale whole-genome sequencing (WGS) analyses have been conducted, including The STROMICS genome study [15], Non-Invasive Prenatal Testing (NIPT) [16], 1001 Tibetan genomes project [17], China Metabolic Analytics Project (ChinaMap) [18], Nyuwa genomic resource [19], and the Westlake BioBank for Chinese (WBBC) [20], which promote a better understanding of the genetic background of Chinese populations and their medical relevance. To provide a high utility of genomic medicine in China, at least four high-resolution haplotype-resolved reference panels were constructed for Chinese populations recently, which can directly facilitate the advancement of precision medicine in China [21]. A series of Han-based large-scale genomic studies filled the gap of missing diversity in human genomes, including the Guangzhou birth cohort [22], ChinaMap [18], Nyuwa [19], WBBC [20], China Kadoorie Biobank (CKB) [21], and Chinese non-small cell lung cancer (NSCLC) cohort [23], which increased our understanding of genetic knowledge of East Asianspecific variations and association with traits. ...