Ewa Rzepecka-Woźniak's research while affiliated with Jagiellonian University and other places
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Publications (34)
The aim of this study is to provide a retrospective assessment of the possibility of determining the severity of atherosclerosis based on postmortem computed tomography (PMCT), autopsy protocols and histopathological examination results. In the first stage of the study, 200 cases were evaluated of persons over 40 years of age in whom postmortem com...
The objective of the present study was to identify metabolites of synthetic cathinone, 3-chloromethcathinone (3-CMC), and to select a potential intake biomarker for this compound. The basis of the experiment was the analysis of blood and urine samples from a case of fatal poisoning with this substance. We also evaluated the stability of 3-CMC and t...
Experienced forensic pathologists would acknowledge that the outcome of a case cannot be predicted with any certainty at the initial stage of the investigation. What may initially present as a complicated case requiring a lengthy autopsy examination with extended procedures may be resolved through autopsy without the need for further opinion. On th...
Recent years saw frequent media reports of young people who die while they are being arrested by the police. Death in these circumstances affects people who are agitated and restrained with the use of force, with their autopsies indicating no unequivocally traumatic cause of death. The goal of this study was to identify the mechanism and circumstan...
The objective of the present study was the development and validation of the method for determining AMB-FUBINACA and its metabolite - AMB-FUBINACA O-desmethyl acid – in blood samples, followed by verification of the method in toxicological judicial and forensic medicine practice employing the example of post-aggression suicide. Most likely in conse...
In recent years PMCT proved to be a valuable tool in post-mortem forensic diagnostics from the very start of use of this procedure of post-mortem examination (Scholing et al. 2009; Thali et al. 2009, 2011; Grabherr et al. 2017). PMCT as a relatively inexpensive and easy-to-access method is recommended for widening of post-mortem forensic examinatio...
The authors present cases of natural death due to arterial or cardiac hemorrhage evaluated using both conventional autopsy examination and post-mortem imaging, including post-mortem computed tomography angiography (PMCTA). Visualization based on CT scan acquisition are presented combined with the results of macroscopic and microscopic examination....
The number of medico-legal post-mortem examinations referring to newborns is considerably low: In the case of the Chair and Department of Forensic Medicine of the author's origin, the autopsy rate of such cases is less than 1 %. Even experienced forensic pathologists can find the technical autopsy procedure of a newborn quite difficult. Post-mortem...
The authors present the opportunities of the application of post-mortem imaging, focusing on post-mortem computed tomography and post-mortem computed tomography angiography in modern forensic investigation of homicide cases. The paper is based on scientific publications related to the subject from ca. the past 10 years, supplemented by the authors'...
The frequency of clinically evident renal tumors is increasing, due to an actual increase in incidence, but also due to an improvement in detection methods. The aim of the present study was to analyze the incidence of renal tumors in an unselected autopsy series. A search for renal tumors was conducted based on the autopsy reports from the Departme...
The report presents an analysis of results of multi-phase post-mortem computed tomography angiography (MPMCTA) scans performed at the Chair of Forensic Medicine, Jagiellonian University Medical College, in cases of stab wounds and incised wounds, as confronted with the results of conventional medico-legal autopsies. The analysis of the material poi...
Introduction
The standard autopsy technique allows checking for the presence of air in pleural cavities, but it is very problematic to estimate the volume of gas. So it is hard to evaluate significance of the symptom, especially for considering as the cause of death.
Methods
Retrospectively, among routinely examined 269 cases with application of P...
Introduction
It seems that acceptance of PMCT as examination preceding conventional autopsy is increasingly widespread. The situation can be more complicated in cases where forensic re-autopsy is ordered because of different reasons.
Methods
In about 1 ½ years' time, the authors applied PMCT in eleven cases where forensic post-mortem re-examinatio...
A frequent request of a prosecutor referring to forensic autopsy is to determine the mechanism of an injury and to identify the weapons used to cause those injuries. This task could be problematic in many ways, including changes in the primary injury caused by medical intervention and the process of healing. To accomplish this task, the forensic pa...
The study represents an attempt at employing segmental hair analysis in complex poisonings with xenobiotic mixtures of heroine - cocaine - amphetamines in the context of the cause of death as a consequence of complex interaction mechanisms which occurred prior to death. Two cases of complex poisonings: heroine - cocaine and heroine - cocaine - amph...
The authors present an analysis of postmortem CT examination in a case of drowning in fresh water of a young male. Both the results of conventional forensic autopsy and radiologic examination have been compared. The analysis is illustrated by two-dimensional and three-dimensional reconstructions based on the DICOM files obtained during postmortem C...
Microvessel density (MVD) and area (MVA) were assessed in 53 clinically silent pituitary microadenomas and in surrounding normal pituitary tissue using CD34 immunostaining and digital image analysis system. Twenty-one microadenomas (40%) were avascular; in the others, both MVD and MVA were significantly lower than in the normal pituitary tissue. No...
The authors present the results of histological examinations of tissue specimens obtained during autopsy of the exhumed corpse of general Władysław Sikorski. In spite of the level of corpse decomposition, the connective tissue stroma was preserved in virtually every specimen.
The report describes a fatal outcome in a 5-year-old male who died after drinking a fatal dose of ethanol at the party held by his parents. Urine and blood alcohol level of the deceased was 0.4 and 0.5 g/dL, what might explain the sudden death of the child. In addition, the analysis of the boy's hair demonstrated the presence of ethyl glucuronide (...
This study undertook a multiparameter evaluation of the death of a 21-year-old woman known to be an abuser of heroin and cocaine.
The toxicological analysis of multiple postmortem specimens such as blood and hair was carried out using liquid chromatography
atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS-MS). The blood...
Pituitary necrosis is mostly a result of pituitary haemorrhage or infarct. The frequency of pituitary necrosis in the Polish population has not yet been investigated. Hence, the aim of this study was to estimate the incidence of pituitary necrotic lesions in forensic autopsy material and to assess possible correlations of pituitary necrosis with se...
A postmortem diagnosis of a "well developed" myocardial infarction is not difficult. In the initial stages of infarction, however, at the stage of gross examination it is impossible to discriminate between the infarcted zone and the undamaged cardiac muscle. When a cardiogenic cause of death is suspected, this fact determines the method of material...
The report presents a fatal poisoning of a neonate occurring in the final stage of gestational life and evoked by his mother, who, while 9 months pregnant, took a toxic dose of clozapine aiming at committing suicide. She was also severely poisoned, but ultimately was saved. The woman had been taking the medication due to schizophrenia and depressio...
Drugs of abuse belonging to the amphetamine derivatives, which are often taken by adolescents and young adults, pose a serious risk associated with uncontrolled ingestion that sometimes leads to fatal outcomes. The number of deaths, however, related to Ecstasy is small when compared to the frequency of its use. The report presents a fatal poisoning...
Current data suggest an influence of the hypothalamic-pituitary-adrenal axis on suicidal behavior. The frequency of pituitary adenomas in suicide victims has not yet been investigated.
The aim of this study was to assess whether the incidence of pituitary adenomas is correlated with suicide.
Serial sections of 151 human pituitary glands obtained up...
The authors present extraordinary autopsy findings, i.e. metallic mercury deposits within the cardiac muscle of a 28-year-old deceased of a male sex. Eleven years previously, the man had injected metallic mercury to the vein in the elbow region with a suicidal intent. Eighteen months later, during diagnostic management of dyspnea, metallic deposits...
The authors presented a case of verification of pathological lesions as a cause of traffic accident where the driver--the culprit--was a fatal victim due to multiple injuries. Histopathological examination of postmortem samples of myocardium was conducted, using the hematoxylin-eosin, Nielsen-Selye and immunohistochemical C9 staining methods in ord...
The author presents two cases of fatal dog bites. In both, the casualties were small children: a newborn and a two-month infant. In the first case, the injuries were inflicted by a puppy, in the second, by three blood-related dogs kept at home.
Arteriosclerosis and its complications are the most frequent cause of death due to cardiovascular diseases. Other different, considerably rare arterial changes can lead to a fatal result as well. The authors presented a case of a 31-year-old male. Postmortem examination revealed a narrowed lumen and thrombosis of the left coronary artery due to fib...
Examination of the cervical spinal cord is a rare additional autopsy technique applied in forensic autopsies. Injuries of the neck region are fatal in a considerable number of cases. However, such technique is neglected especially while a different cause of death is found. Research on 316 autopsy cases (about 10% of all cases during that time) was...
In a considerable number of cases of sudden death "routine" diagnosis is insufficient to prove myocardial ischaemia especially in early myocardial infarction. One of the additional methods of postmortem diagnosis is detection of cardiomyocyte DNA fragmentation related to apoptosis. The authors presented research on 34 cases. All postmortem examinat...
Citations
... 4-FMC human metabolism was previously assessed (17). 3-and 4-CMC metabolic transformations have been recently studied, although the investigations were partial (5,16,18). To the best of our knowledge, 4-BMC metabolism has not been studied. ...
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... PMCT is a well-established and validated tool used in medicolegal death investigation [11,12] providing a permanent digital record of the deceased and revealing significant findings prior to autopsy, which allows pre-examination planning or further investigation and a tailored approach to the autopsy (for example, in this case, internal examination of the head was not required). The PMCT readily demonstrates sites of hemorrhage, but as it is a non-contrast scan, it has limitations, in that it may not depict the site of vascular rupture or visceral injury causing bleeding [13]. Hemorrhage-related deaths may arise from natural disease or trauma. ...
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... These have been published by EPSR (jointly with the International Society of Forensic Radiology and Imaging (ISFRI) [8]) and the Society of Pediatric Radiology (SPR) [9]. Whilst there are reports that have demonstrated some utility in ventilated PMCT [10] or the addition of intravascular contrast (e.g., PMCTA) [11,12], neither is routinely practiced in children. ...
... PMCT images provide a wealth of imaging data that can be evaluated by forensic radiologists or be used for medical image analysis purposes including radiomics. PMCT is considered to be a valuable adjunct to autopsy in gunshot-related wound examination [13], sharp force trauma [14], and blunt force related deaths [10]. ...
... [11] More recently, in studies conducted in Poland and Lebanon for ART, high male:female ratios of 4.7:1 and 4:1, respectively, were found. [12,13] Therefore, the gender-related observation in our present study is in concordance with all available data in national and international literature. However, there are variations in the degree of male:female ratios, ranging from a minimum of 1.5:1 to a maximum of 4.17:1. ...
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... For example, the conventional method does not have the capability to assess the volume of accumulated gas or discriminate between ordinary and tension pneumothorax (pressure pneumothorax), which may be Tabela III. Zestawienie procentowego udziału poszczególnych obrażeń i zespołów obrażeń klatki piersiowej w grupie przypadków bez stwierdzonej odmy opłucnowej (n = 255) informacji pozwalających odróżnić odmę zwykłą od prężnej (wentylowej), co może mieć decydujące znaczenie dla mechanizmu zgonu [18]. Niewątpliwie prezentowane wyniki badań wskazują na dużą przydatność PMCT w diagnozowaniu odmy opłucnowej. ...
... Consequently, various postmortem angiographic techniques have been developed (10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Probably the most widespread single approach for postmortem angiography today is multiphase postmortem CT angiography (20)(21)(22)(23)(24)(25)(26)(27), first described in 2011 (14). This technique uses a standardized procedure on the basis of a defined injection and a scanning protocol that uses a specific perfusion device and an oil-based contrast agent of specific viscosity. ...
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... Wirtopsja to termin wywodzący się z dwóch słów "wirtualny" i "autopsja", który wykorzystuje metody obrazowania rutynowo stosowane w medycynie klinicznej, takie jak tomografia komputerowa i rezonans magnetyczny, w celu ustalenia obrażeń jakich doznał zmarły oraz przyczyny i mechanizmu zgonu [39]. Dzięki technikom zastoso-examination, using CT or MRI, several thousand images of the organ under examination are created, which the computer combines into a single three-dimensional image [40]. The resulting images can be cataloged and evaluated using artificial intelligence methods. ...
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... Δ 9 -tetrahydrokannabinol (Δ 9 -THC) i jego metabolity: kwas 11-nor-9-karboksy-tetrahydrokannabinolowy (THC-COOH) oraz 11-hydroksy-tertahydrokannabinol (11-OH-THC), ekstrahowano i oznaczano zgodnie z procedurą metody analitycznej zaprezentowanej w pracy Rojek i Kłys [10], opiaty według procedury przedstawionej przez Kłys i Rojka [11], a kokainę zgodnie z procedurą opisaną w pracy Kłys i wsp. [12]. ...
... The diagnosis of the cause and the establishment of the manner of death in submersion cases are considered a challenge for forensic pathologists [1][2][3][4]. It is generally accepted that not all persons whose bodies are recovered from water have drowned. ...
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