Evelyn Y. Xue's research while affiliated with The University of Hong Kong and other places
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Publications (17)
The infiltration and cytotoxicity of chimeric antigen receptor (CAR)‐T cells are crucial for effective elimination of solid tumors. While metallo‐immunotherapy is a promising strategy that can activate the antitumor immunity, its role in promoting CAR‐T cell therapy remains elusive. We have previously reported the first single‐element nanomaterial...
An acetal-linked dimeric phthalocyanine has been synthesised and immobilised on the surface of gold nanobipyramids. The resulting nanocomposite serves as a highly sensitive probe for intracellular pH through its acid-responsive...
As an effective and non‐invasive treatment modality for cancer, photodynamic therapy (PDT) has attracted considerable interest. With the recent advances in the photosensitizing agents, the fiber‐optic systems, and other aspects, its application is extended to a wide range of superficial and localized cancers. However, for the few clinically used ph...
The utilisation of enzymes as stimuli can activate theranostic agents in a highly specific manner. We report herein a far-red-absorbing boron dipyrromethene-based photosensitiser that is responsive towards the cancer-associated human...
Photodynamic therapy and sonodynamic therapy are two highly promising modalities for cancer treatment. The latter holds an additional advantage in deep‐tumor therapy owing to the deep penetration of the ultrasonic radiation. The therapeutic efficacy depends highly on the photo/ultrasound‐responsive properties of the sensitizers as well as their tum...
Pt(II)-BODIPY complexes combine the chemotherapeutic activity of Pt(II) with the photocytotoxicity of BODIPYs. Additional conjugation with targeting ligands can boost the uptake by cancer cells that overexpress the corresponding receptors. We describe two Pt(II) triangles, 1 and 2, built with pyridyl BODIPYs functionalized with glucose (3) or triet...
We report herein a versatile and efficient bioorthogonal strategy to actualise targeted delivery and site-specific activation of photosensitisers for precise antitumoural photodynamic therapy. The strategy involved the use of an isonitrile-caged distyryl boron dipyrromethene-based photosensitiser, labelled as NC-DSBDP, of which the photoactivities...
Invited for this month′s cover is the group of Prof. Dennis K. P. Ng at The Chinese University of Hong Kong. The cover picture shows the selective internalization of molecules of a di‐galactosyl zinc(II) phthalocyanine into a cancer cell. Upon light irradiation, these molecules are excited and interact with the endogenous oxygen to generate highly...
The cover picture shows the selective internalization of molecules of a di‐galactosyl zinc(II) phthalocyanine into a cancer cell. Upon light irradiation, these molecules are excited and interact with the endogenous oxygen to generate highly reactive singlet oxygen, which oxidatively damages the cellular components, leading to cell death eventually....
A series of di‐α‐substituted zinc(II) phthalocyanines with different number of galactose moieties, ranging from 1 to 8, namely Pc‐galn (n=1, 2, 4, and 8) were designed and synthesized. The synthesis involved the copper‐catalyzed azide‐alkyne cycloaddition reaction of a mono‐ or dialkynyl zinc(II) phthalocyanine with an acetyl‐protected galactosyl a...
Atherosclerosis treatments by gene regulation are garnering attention, yet delivery of gene cargoes to atherosclerotic plaques remains inefficient. Here, we demonstrate that assembly of therapeutic oligonucleotides into a three-dimensional spherical nucleic acid nanostructure improves their systemic delivery to the plaque and the treatment of ather...
A pH‐responsive drug delivery system based on mesoporous silica nanoparticles (MSN) has been prepared for the delivery of three drugs with different modes of action (phthalocyanine (Pc) camptothecin (CPT) and doxorubicin (DOX)). The pores of the MSN were loaded with a photoactive conjugate formed from Pc and CPT joined by a glutathione‐sensitive li...
A pH‐responsive drug delivery system (DDS) based on mesoporous silica nanoparticles (MSNs) has been prepared for the delivery of three anticancer drugs with different modes of action. The novelty of this system is its ability to combine synergistic chemotherapy and photodynamic therapy. A photoactive conjugate of a phthalocyanine (Pc) and a topoiso...
A peptide-conjugated zinc(ii) phthalocyanine containing the epidermal growth factor receptor-targeted heptapeptide QRHKPRE has been prepared. The conjugate labelled as ZnPc-QRH* can selectively bind to the cell membrane of HT29 human colorectal adenocarcinoma cells in 10 min followed by internalisation upon prolonged incubation via receptor-mediate...
Citations
... 70 In a seminal paper, they showed that the reaction of cis-bis(phosphine)platinum(II) ditriate with 4,4 ′ -bipy yields macrocycle 24 as the sole cyclic molecule (Fig. 3a). 71 Following a similar strategy, many macrocyclic structures have been reported to date, [72][73][74][75][76][77][78][79] demonstrating that different shapes and pore sizes can be easily constructed from readily available components. ...
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... The introduction of a carboxylate group into the meso-position of distyrylBODIPY is known to result in improved fluorescent properties. To "mask" the photoactivity of the photosensitizer, the same authors proposed introducing a self-immolative fragment via the carboxyl group [152]. For targeted delivery of the photosensitizer 79 to tumor cells, a [4+1] cycloaddition reaction of isocyanide with tetrazine was utilized ( Figure 40). ...
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... Wei et al. [93] proposed a nanostructure based on non-cationic nucleic acids, with a core of PEG-coated SPION and a shell containing a layer of phosphorothioate (PS)-modified microRNA-146a (miR-146a) oligonucleotide. These oligonucleotides were linked to PEGcoated SPION. ...
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... By the introduction of Fc motifs, CyD-based carrier becomes sensitive to various redox agents, e.g., Fe 3+ , H 2 O 2 , and sodium hypochlorite (NaClO); this can also be achieved by electrochemical oxidative method. Concerning interactions with Fc derivatives, β-CyD showed the highest binding stability, with a formation constant of 2.2 × 10 3 M −1 [89]. Meanwhile, Fc + cannot be included in the cavity of CyDs [78]. ...
... Polymeric micelles are frequently employed for the site-specific delivery of bioactive agents against tumors [22]. In particular, cyclodextrin, which is a cyclic oligosaccharide, is believed to be an ideal candidate for the solubilization of hydrophobic drugs and site-specific delivery of bioactive agents [20,[24][25][26]. Paul et al. reported that hydroxypropyl-β-cyclodextrin increases the aqueous solubility of Ce6 at pH 7 through the formation of an inclusion complex and then improves its phototoxicity against oral squamous carcinoma cells through enhanced ROS production [20]. ...
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... In this manner, they combined chemotherapy and photosensitizers for photodynamic therapy (PDT). Upon irradiation of the samples, the Pc phototoxicity enhances the chemotoxicity of DOX and CPT (Martinez-Edo et al., 2021). In a further step, self-propelled NPs also enable a more efficient manner to reach their target site without the need for external stimuli. ...
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... For example, linear 7-mer peptide ligands SYPIPDT and HTSDQTN were selected on A-431 epidermoid cancer cells and exhibited binding affinities for EGFR and dose-dependent inhibitory effects on EGFR protein phosphorylation [37]. The linear QRHKPRE peptide was Cy5.5-conjugated, validated for in vitro and in vivo binding affinity, and exploited for tumor imaging and photodynamic therapy in mouse colorectal cancer models [38,39]. Phage display was also used to identify peptide ligands of the tumor-specific EGFRvIII mutant form in several tumor cell lines [45]. ...
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