Eugene Du Toit's research while affiliated with Griffith University and other places
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Publications (15)
Background: Increased prevalence of mental disorders has become a significant public health concern. Recent studies have linked nutrition to depression and anxiety, suggesting that dietary changes or nutritional supplementation may be beneficial in improving mental disorders. Polyphenols have anti-inflammatory and antioxidant properties that may co...
A mixed-mode or ‘‘flipped’’ model of learning focusses on supporting a high level of student engagement, student motivation, and the transferability of specific course content. A blend of online resources and face-to-face (F2F) learning facilitates meaningful interaction between peers, while building a capacity for self-directed and lifelong learni...
Wound healing is an important outcome of tissue damage and can be stimulated by adenosine released from cells during events such as tissue injury, ischaemia or tumour growth. The aim of this research was to determine the potency and efficacy of adenosine A1, A2A and A2B receptor agonists on the rate of wound healing and cell proliferation in human...
Background
Multiple choice questions are commonly used in summative assessment. It is still common practice for tertiary institutions and accrediting bodies to use five-option single best answer multiple choice questions, despite a substantial body of evidence showing that multiple choice questions with only three or four options provide effective...
Major depressive disorder (MDD) and obesity are dominant and inter-related health burdens. Obesity is a risk factor for MDD, and there is evidence MDD increases risk of obesity. However, description of a bidirectional relationship between obesity and MDD is misleading, as closer examination reveals distinct unidirectional relationships in MDD subty...
Purpose:
Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose intolerance is not well chara...
Bilirubin, a potentially toxic catabolite of heme and indicator of hepato-biliary insufficiency, exhibits potent cardiac and vascular protective properties. Individuals with Gilbert's syndrome (GS) may experience hyperbilirubinemia in response to stressors including reduced hepatic bilirubin excretion/increased red blood cell breakdown, with indivi...
Mitochondrial fission protein, dynamin‐related protein‐1 (DRP‐1), may be a key determinant of cardiac resistance to ischemia‐reperfusion (I‐R) and other stresses. We examined the impact of I‐R on myocardial expression of DRP‐1 (together with Akt and Erk1/2), mitochondrial respiration, and injury in I‐R hearts in 4mo male C57Bl/6 mice subject to DRP...
Cardiovascular Disease (CVD) is the world’s greatest killer, claiming the lives of around 17.2 million men and women per year. Bilirubin is a novel antioxidant, which has been cited to reduce ischemia‐reperfusion injury in various tissues; however research into cardiac ischemia‐reperfusion injury is yet to be completed. The aim of this research was...
Citations
... Additionally, the consumption of anthocyanin-rich fruits has been associated with beneficial effects on the brain through neuroinflammation, neurogenesis, and neuronal signaling modulation [115]. Furthermore, polyphenol supplementation is able to effectively modulate anxiety and depression [116]. Polyphenols are currently stated as potential anti-aging agents because they slow down the shortening of telomeres [117]. ...
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... MiR-214 was found to negatively regulated the level of A2AR. Adenosine is dramatically increased in cells or tissues damaged by ischemia, inflammatory reactions, and other injuries, and A2AR may participate in this transduction process 35 . Adenosine receptor activation has a potential pro-angiogenic effect, which is associated with the downregulation of thrombospondin-1 adhesive protein TAP1 by A2AR agonists 36 . ...
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... MCQ assessments present several advantages, such as the ability to help evaluate the learning levels of a vast number of students in an expansive topic range under shorter durations [1]. In general, MCQs are mostly employed for summative assessments of students and trainees in medical colleges [2]. However, they can be used for both formative and summative analyses [1]. ...
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... Depression may be a strong predictor of obesity for a number of reasons. First, hypersomnia and hyperplasia are caused by depression (24) . which consequently increased energy consumption and decreased energy expenditure, respectively (25) . ...
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... Bilirubin is generally considered a waste product with li le or no physiological purpose and can be toxic if it accumulates. However, it has been recently recognized as a potent cardiac and vascular protective agent, suggesting its physiological importance [10]. Indeed, bilirubin reduces the risk of developing atherosclerosis and other CVDs through several inhibiting mechanisms, including low-density lipoprotein oxidation, vascular smooth muscle cell proliferation, and endothelial dysfunction [44, 68,69]. ...
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... Extending this observation, our analysis of 13 tumor types revealed that mRNA levels of GPR84 are restricted to macrophages from the tumor, but not adjacent benign and other tissues. In accordance with this observation, a growing body of evidence supports a regulatory role of GPR84 in macrophage-mediated inflammation in lung injury processes [47], kidney fibrosis [48], diabetes [49], and the central nervous system [50]. In addition, one recent in vitro CRISPR screen has identified GPR84 as an enhancer for phagocytosis of Ramos lymphoma cells [51]; which can be escaped by overexpression of adipocyte plasma membrane-associated protein (APMAP) [51]. ...
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