Erdal Yilmaz's research while affiliated with Firat University and other places
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Publications (42)
Objective: Diabetes is a significant risk factor for early onset of atherosclerosis. In this study, it was aimed to determine whether total homocysteine (tHcy), lipoprotein(a) [Lp(a)] and von Willebrand factor (vWF) levels have an early predictive value like glycolysated hemoglobin (HbA1c) levels in assessment of metabolic condition of children wit...
Objective: Diabetes is a significant risk factor for early onset of atherosclerosis. In this study, it was aimed to determine whether total homocysteine (tHcy), lipoprotein(a) [Lp(a)] and von Willebrand factor (vWF) levels have an early predictive value like glycolysated hemoglobin (HbA1c) levels in assessment of metabolic condition of children wit...
Objective:
To examine relationship between carotid intima-media thickness (IMT) and central obesity, cardiovasculary risk factors, and chronic inflammation markers in overweight and obese schoolchildren in Eastern Turkey.
Methods:
A cross-sectional school-based survey on 2765 schoolchildren was performed. We collected the clinical data (age, sex...
Most studies regarding the influence of ultraviolet radiation on levels of inflammatory cytokines were conducted mainly in cultures of human keratinocytes or in laboratory animals. Few studies were also performed in human subjects.
To investigate the influence of the use of phototherapy on the levels of tumor necrosis factor (TNF)-alpha, interleuki...
Absence of the pericardium can vary from partial to complete absence. Patients with complete absence of the pericardium are either asymptomatic or have nonspecific chest pain, and no treatment is needed. Patients with partial absence of the pericardium are at risk for possible symptomatic herniation of the left atrial appendage or left ventricle, l...
To evaluate the expression of lymphocyte subsets in newborns diagnosed as culture proven or culture negative sepsis and to investigate the differentiation. The aim of this study is to explore neonatal immunology in newborns diagnosed as culture proven or culture negative neonatal sepsis and to identify their place in the diagnosis. This prospective...
Prolidase, a specific iminopeptidase involved in collagen turnover, is especially active in growing tissues.
To investigate the relationship between cord blood prolidase activity and both birth weight and gestational age. Methods: Cord blood was collected consecutively from 50 healthy newborns (35 term, 15 preterm). Prolidase activity was measured...
The aim of this study was to investigate the relationship between the varying degrees of obesity and blood glucocorticoid levels in obese children and adolescents with and without metabolic syndrome features.
We studied 241 obese children and adolescents aged between 2 and 17.6 years; 127 boys and 114 girls. All children underwent an oral glucose t...
Background/Aim. Ghrelin has effects on nutrient intake and growth. The cause of growth retardation in congenital heart disease is multifactorial. The aim of the present study is to investigate the ghrelin in congenital heart disease and the association of ghrelin with TNF-α and IL-6.
Materials and methods. We measured serum ghrelin, TNF-α, and IL-6...
The prevalence of obesity in children has increased dramatically over the last 20-30 years in developed countries. The aim of this study was to evaluate the oxidative and antioxidant status and any correlation with leptin in obese prepubertal children. A cross-sectional study was made of healthy children from ten elementary schools in the province...
Aim: This study aims to reveal the efficiency of immunoprophylaxis and Hepatitis B vaccine administration program applied on babies born from mothers with positive Hepatitis B surface antigen (HBsAg). Material and Method: Cases born from mothers with positive Hepatitis B surface antigen were included in the study. After blood samples were taken fro...
To determine serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up.
This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (n=12), as culture-negative sepsis (n=21...
The purpose of this present study was to evaluate the serum levels of ET-1 and TGF-β in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-β were obtained from newborns with diagnosis as meconium aspiration synd...
Diabetes mellitus is a chronic endocrine and metabolic disease; characterized by hyperglycemia due to deficiency of either insulin secretion or insulin effect, causes severe complications in the long term. Insulin is a hormon synthesized at beta cells of pancreas and controls energy homeostasis. Either relative or absolute deficiency of insulin cau...
In this study, seroprevalence of mumps, varicella and rubella was investigated in 803 unvaccinated children in eastern Turkey whose ages ranged between 1 and 16 years. Mumps IgG, varicella IgG and rubella IgG antibody levels in all children were studied by enzyme-linked immunosorbent assay (ELISA) method. Information regarding socioeconomic charact...
Homocysteine is an aminoacid which contains sulfur but not included in protein structure and can not be taken by diet. It's an intermediate product in methionine metabolism. Eighty-ninety percent of them are bound to albumin in plasma and remainder is free. The free part is not stable and quickly converted to oxidased forms. Plasma homocysteine lev...
Immune thrombocytopenic purpura (ITP) is a clinical case causing changes in volume parameters, as well as in the number of thrombocytes. In this study, we aimed to determine thrombocyte volume parameters (mean platelet volume, MPV; platelet distribution width, PDW) patients with acute ITP and the effects on them of different treatments. Of the 56 p...
Approximately 25-30% of patients with chronic immune thrombocytopenic purpura (ITP) do not respond to established therapeutic regimens (corticosteroids, IVIg, anti-D, splenectomy). The mechanism of action of rituximab (anti-CD20) causes opsonization of B cells, which inhibits macrophage Fc receptor function and clearance of IgG-coated platelets. We...
We aimed to determine the effects of intravenous iron therapy on blood parameters in pediatric patients who do not tolerate oral iron therapy for any reason.
The patient group consisted of candidates for elective operations requiring blood transfusions in order to raise hemoglobin (Hb) concentrations rapidly and for whom oral iron administration is...
The prevalence rates of hypoferritinemia (IDec/one abnormal indicator), iron deficiency (IDef/two abnormal indicators) and iron deficiency anemia (IDA) in children who were referred to the outpatient clinics of the Department of Pediatrics for the first time within 1 month were investigated. Exclusion criteria were iron therapy before and during th...
Insulin-dependent diabetes mellitus (IDDM) is a chronic disease characterized by T-cell-dependent autoimmune destruction of the insulin-producing beta cells in the pancreatic islets of Langerhans, resulting in an absolute lack of insulin. T cells are activated in response to islet-dominant autoantigens, the result being the development of IDDM. Ins...
It has been well documented that human milk contains several
immunomodulator components which are important during infant
period when the newborn's immune system is still under
development. In this study, we aim at examining levels of
cytokines, zinc (Zn), and copper (Cu) in milk from
mothers of premature and mature infants, and comparing changes
d...
This prospective study, performed in 76 children with a urinary tract infection (UTI), evaluates the diagnostic value of procalcitonin (PCT) and proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) in children with acute pyelonephritis documented by dimercaptosuccinic acid scintigraphy (DMSA). Renal parenchymal involvement was assessed by (99m...
Reflex sympathetic dystrophy syndrome (RSDS) is characterized by severe pain, swelling and autonomic dysfunction of the affected extremity. Major or minor trauma is the most common initiating factor. Pain in the affected extremity is usually associated with vasomotor and sudomotor changes. We report an interesting case of RSDS of the right knee joi...
Immune thrombocytopenic purpura (ITP) is certainly a common and benign disease of infancy and childhood. The major complication is intracranial hemorrhage, the fear of which drives physicians to initiate treatment. The goals of therapy involve maintaining a safe platelet count while minimizing toxicities from the treatment. It has been reported tha...
The aim is to examine whether the changes in pleural fluid interleukin (IL)-1β, IL-2, IL-6, and IL-8 levels were significant in differential diagnosis of childhood pleural effusions. IL-1β, IL-2, IL-6, and IL-8 levels in pleural fluids of all 36 patients were measured. The levels of IL-1β, IL-2, IL-6, and IL-8 in pleural fluids were statistically s...
Iron and selenium are trace elements necessary for the maintenance of life and health. Iron deficiency is the most common nutritional deficiency among children in the world. The purpose of this study was to evaluate plasma selenium concentrations in children with iron deficiency anemia (IDA). Plasma selenium levels were investigated in 56 children...
Fibrous hamartoma of infancy is an uncommon, self-limiting benign tumor that presents during the first two years of life, developing from subcutaneous fibrous tissue proliferation at almost any site. A male child aged eight months was accepted at our clinic because of painless mass at left axilla since two months. This mass was histopathologically...
Many treatment modalities have been described for thoracic empyema in children but the optimal timing of appropriate treatment remains controversial. The aim of this study is to find out the outcome of postpneumonic empyema in children after a conservative approach.
The reports of patients who were admitted to our hospital from January 1990 to Octo...
lnterleukin-8 (IL-8) is produced in monocytes and vascular endothelial cells in response to stimulation with bacteria or lipopolysaccharides, and is released from these cells into blood stream or tissue fluid.
Cerebrospinal fluid (CSF) levels of interleukin-8 in 56 children with nonbacterial, bacterial and tuberculous meningitis (TBM), and in 15 co...
Forty-nine patients, aged 3 months to 13 years, were studied to determine the clinical presentation, bacteriology, treatment and outcome of empyema complicating pneumonia in children. There were 28 (57.2%) males and 21 (42.8%) females in the study, with a male/female ratio of 1.3/1. We found malnutrition in 15 (30.6%) patients. The most common symp...
Citations
... In our study hs-CRP was assayed along with IL6 or resistin and it shows a marked rise in neonates than in control groups and may be of good value than the other markers in the diagnosis of neonatal sepsis. Thus, the above results obtained from our study suggest that the CRP or IL 6 or resitin were better predictors and dependable markers of neonatal sepsis.Moreover, our study showed the serum level of IL 6 is significantly higher in the clinically suspected cases of neonatal sepsis group than the normal healthy controls which is in confirmation with other studies [6,10,25,26]. A study revealed that serum IL 6 level showed a highly significant value even in umbilical cord blood in septic neonates [27]. ...
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... Hamartomlarda spontan regresyon veya malign transformasyon şimdiye kadar görülmemiştir. Lezyon başlangıçta hızlı bir büyüme paterni gösterirken yaş ilerledikçe büyüme hızı yavaşlar (8). Diğer yenidoğan dispne nedenleri ile kıyaslandığında hipofaringeal hamartomlar dispnenin oldukça nadir sebeplerindendir. ...
... With the deepening of the research on the pathophysiological mechanism of sepsis, modulation of immune-inflammatory disorders has become a new direction for the treatment of sepsis [21]. In sepsis, infection first causes increased secretion of core pro-inflammatory factors such as TNF-α and IL-1β [22,23]. It has been reported that IL-6 was tightly associated with sepsis mortality and can be used as a predictor of sepsis severity due to its slow metabolism and easy detection [24,25]. ...
... It is reported in various studies that the administration of active and passive immune prophylaxis to babies of mothers with HBsAg positivity in the first 12-24 hours of life immediately after birth prevents 90-95% transmission of the HBV to the infant (1,2,18,19). ...
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... Diabetes Mellitus, or hyperglycemia, is a chronic condition characterized by high glucose concentration in blood due to the insufficient amount of functional insulin [1]. The most common types of conventional insulin therapy to treat hyperglycemia make use of syringes, pens, and pumps. ...
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... In cases of jaundice emerging in newborns in the first 24 hours, maternal diabetes has been shown to be a risk factor for the infant (14). Ince et al. determined the frequency of hyperbilirubinemia as 41.9% in the infants of diabetic mothers, and Akarsu et al (15,16). determined this rate to be higher at 50%. ...
... The HPA axis and the sympathetic and parasympathetic components of the ANS share functional relationships [45,83]. Specifically, crosstalk between the HPA axis and ANS helps to coordinate stress responses, circadian rhythm [13 •], immunity [84], and metabolism [85], among other tasks. In the case of a dysfunctional ANS, the HPA axis may also become dysfunctional, or vice versa. ...
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... The main limitation of this study is the lack of longitudinal information regarding biochemical markers (e.g., glucose and insulin levels, HOMA, TC, LDL-C, HDL-C, TG, ALT, and CRP), which are well-known indicators of cardiovascular health [40], being associated with both BFM and cIMT [6,41,42]. Another possible limitation is the lack of data among girls on the timing of menarche. Nevertheless, there is no consensus that pubertal timing has a significant effect on the vascular structure and function in adults when controlling for pre-pubertal BMI [43]. ...
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... Se denomina síndrome de Bart (SB) a la ausencia congénita localizada de piel (ACLP), ampollas generalizadas y alteraciones ungueales, se desconoce una etiología específica, existe una alteración genética del cromosoma 3 con patrón autosómico dominante de herencia [1,2]. La aplasia cutis está presente en los subtipos de epidermólisis bullosa, denominándose Síndrome de Bart. ...
... Hyperthermia is a result of increased irradiance rather than the type of light source of phototherapy [34]. Second, hyperthermia can be explained by the impact of phototherapy light on the release of pyrogenic cytokines [35]. The increased exposure time in the CPT group explains the elevated body temperature due to the increase in the irradiance of light and thus, pyrogenic cytokines. ...
