Elizabeth A. Bevins's research while affiliated with University of California and other places

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with several neurologic manifestations including the development of cerebral lesions resembling CNS vasculitis in elderly patients with severe coronavirus disease-19 (COVID-19)1-4. Here, we report additional evidence for COVID-19-related CNS vasculitis, for the first time confirmed by biopsy, in a young healthy patient with otherwise mild COVID-19 infection.

Purpose of Review This article discusses the diagnostic evaluation and management of reversible dementia syndromes. It highlights clinical syndromes and explores the recent literature implicating certain reversible factors in Alzheimer’s disease pathogenesis. Recent Findings The prevalence of fully reversible dementia is low, but there is growing awareness for potentially reversible contributors to neurodegenerative disease. In particular, exposure to anticholinergic medications, obstructive sleep apnea, and depression have emerged as potentially modifiable targets in the pathogenesis of preclinical and early Alzheimer’s disease. Treatment of these factors may not only reverse any direct cognitive effects but also prevent downstream neurodegeneration. Summary There is substantial opportunity to improve outcome in patients with dementia due to reversible etiologies. Even in the setting of primary neurodegenerative disease, conscientious effort is required to recognize and address reversible contributors.