Einat Even-Sapir's research while affiliated with Tel Aviv Sourasky Medical Center and other places
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Publications (178)
Objective
To investigate the prognostic significance of near-complete metabolic response on initial follow-up PET/CT after primary chemoradiation treatment of cervical cancer.
Methods
Survival data were retrospectively compared between patients who had complete metabolic response on first follow-up PET/CT, 3 months after chemoradiation (group 1) w...
Although prostate-specific membrane antigen (PSMA) PET/CT has been shown valuable for staging biopsy-proven [B(+)] high-risk prostate cancer, elderly patients are occasionally referred for PSMA PET/CT without a preimaging confirming biopsy [B(-)]. The current study evaluated the rate, clinical characteristics, and PET-based stage of elderly B(-) pa...
Prostatic neuroendocrine malignancies represent a spectrum of diseases. Treatment-induced neuroendocrine differentiation (tiNED) in hormonally treated adenocarcinoma has been the subject of a large amount of recent research. However, the identification of neuroendocrine features in treatment-naïve prostatic tumor raises a differential diagnosis bet...
The interpretation of 18F-DOPA PET/CT performed for assessing nigrostriatal dysfunction (NSD) is usually based on visual assessment of the uptake in the basal ganglia (VA-BG). In the present study, we evaluate the diagnostic performance of an automated method that assesses BG uptake (AM-BG) and of methods that assess pineal body uptake, and examine...
![Representative examples of [¹⁸F]FDG-avid lesions detected on the PET of...](publication/366902249/figure/fig2/AS:11431281128918400@1679453449108/Representative-examples-of-FFDG-avid-lesions-detected-on-the-PET-of-the-PET-MRI-only_Q320.jpg)
![Representative examples of lesions with no or faint [¹⁸F]FDG uptake...](publication/366902249/figure/fig4/AS:11431281128909950@1679453449538/Representative-examples-of-lesions-with-no-or-faint-FFDG-uptake-that-were-identified_Q320.jpg)
Purpose
The recent introduction of integrated PET-MRI systems into practice seems promising in oncologic imaging, and efforts are made to specify their added values. The current study evaluates the added values of PET-MRI over PET-CT in detecting active malignant hepatic lesions.
Methods
As part of an ongoing prospective study in our institution t...
Purpose: While PSMA PET-CT has been shown valuable for staging biopsy-proven [B(+)] high-risk prostate cancer (PCa), elderly patients are occasionally referred to PSMA PET-CT without pre-imaging confirming biopsy [B(-)]. The current study evaluates the rate, clinical characteristics, and PET-based stage of B(-) elderly patients, and explores if bio...
MRI was suggested as a promising method for the diagnosis and assessment of Parkinson’s Disease (PD). We aimed to assess the sensitivity of neuromelanin-MRI and T 2 * with radiomics analysis for detecting PD, identifying individuals at risk, and evaluating genotype-related differences. Patients with PD and non-manifesting (NM) participants [NM-carr...
Background:
Larynx preservation protocols (LPP) for glottic primary squamous cell carcinoma has gained popularity worldwide. Direct laryngoscopy (DL) with biopsy is mandated when recurrence is suspected. The efficacy of 18Fluoro-deoxy-glucose positron emission computerized tomography (PET-CT) as alternative first-line diagnostic investigation in s...
Purpose: The recent introduction of integrated PET-MRI systems into practice seems promising in oncologic imaging. Efforts are made to specify the added-values of this modality. The current study evaluates the added-values of PET-MRI over PET-CT in detecting active malignant hepatic lesions.
Methods: As part of an ongoing prospective study in our i...
Purpose
to assess the value of staging ⁶⁸Ga-PSMA-11 PET/CT in elderly patients with biopsy-proven or high clinical suspicion of prostate cancer (PCa).
Methods
100 consecutive patients 80 years of age and older referred for ⁶⁸Ga-PSMA-11 PET/CT with biopsy proven high-risk PCa (n = 66 pts) or high clinical suspicion of clinically relevant PCa withou...
Background
Neuroendocrine malignancies of the prostate represent a spectrum of diseases. Treatment-induced neuroendocrine differentiation (tiNED) in hormonally treated adenocarcinoma has been the subject of a large amount of recent research. However, the identification of neuroendocrine features in treatment-naïve prostatic tumor raises a different...
PurposeThe aim of the study was to elaborate the incidence and type of skeletal involvement in a large cohort of patients with newly diagnosed prostate cancer (PCa) referred for Ga-68 PSMA-11 PET/CT staging in a single center.Methods
Study cohort included 963 consecutive patients with newly diagnosed PCa referred for Ga-68 PSMA-11 PET/CT study for...
Purpose
The incidence of COVID-19 vaccine-associated hypermetabolic lymphadenopathy (VAHL) is high following the administration of the first and second BNT162b2 vaccine doses. The impact of this finding on [¹⁸F]FDG PET-CT interpretation and its correlation with the induced humoral immunity have been reported. Assuming the amnestic immune response i...
Introduction:
Current guidelines don't support the use of pretreatment imaging in patients with favorable intermediate-risk prostate cancer. 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) is more accurate than conventional imaging for preoperative staging. We aimed to evaluate whether pretrea...
PurposeThe introduction of CD19-specific chimeric antigen receptor T-cell therapy (CAR-T) for treatment of relapsed/refractory diffuse large B cell lymphoma (R/R DLBCL) gives hope to patients with otherwise dismal prognosis. Therapy outcomes, however, depend upon selection of patients and accurate early identification of non-responders. Patients tr...
![PET characteristics based on the physiologic [ 18 F]FDG-uptake in the...](publication/358317039/figure/tbl1/AS:1122753495216128@1644696701581/PET-characteristics-based-on-the-physiologic-18-FFDG-uptake-in-the-location-of-the_Q320.jpg)
Simple Summary
MALT lymphoma represents a relatively rare lymphoma subtype that arises in different extranodal anatomic locations. In the current paper we summarize our experience in assessing disease extent and metabolic characteristics of MALT lymphomas with [¹⁸F]FDG PET-CT at staging, and aim to highlight the strengths and challenges this imagin...
Background
[ ¹⁸ F]-Fluorodeoxyglucose (FDG) positron emission tomography–computed tomography (PET/CT) may sometimes be suboptimal for imaging gastric adenocarcinoma. The recently introduced [ ⁶⁸ Ga]Ga-FAPI-04 (FAPI) PET/CT targets tumor stroma and has shown considerable potential in evaluating the extent of disease in a variety of tumors.
Methods...
Purpose: The aim of the study was to elaborate the incidence and type of skeletal involvement in a large cohort of patients with newly diagnosed prostate cancer (PCa) referred for Ga-68 PSMA-11 PET/CT staging in a single center.
Methods: Study cohort included 963 consecutive patients with newly diagnosed PCa referred Ga-68 PSMA-11 PET/CT study for...
Purpose
Vaccine-associated hypermetabolic lymphadenopathy (VAHL) is frequently observed on [¹⁸F]FDG PET-CT following BNT162b2 administration. Recent data suggest a prominent B cell germinal-center (GC) response elicited by mRNA vaccines in draining lymph nodes. Thus, in this study we aimed to explore the correlation between VAHL and humoral immunit...
High-risk prostate cancer is associated with adverse pathology and unfavorable outcomes after radical prostatectomy. ⁶⁸Ga-PSMA PET/CT is more accurate than conventional imaging for preoperative staging. We aimed to evaluate whether lymph node involvement on ⁶⁸Ga-PSMA PET/CT prior to radical prostatectomy in patients with high-risk prostate cancer i...
Purpose: The incidence of Covid-19 vaccine-associated hypermetabolic lymphadenopathy (VAHL) is high following the administration of the first and second BNT162b2 vaccine doses. The impact of this finding on [¹⁸F]FDG PET-CT interpretation and its correlation with the induced humoral immunity have been reported. Assuming the amnestic immune response...
Purpose: The introduction of CD19-specific chimeric antigen receptor T-cell therapy (CAR-T) for treatment of relapsed/refractory diffuse large B cell lymphoma (R/R DLBCL) gives hope to patients with otherwise dismal prognosis. Therapy outcomes depend, however, on selection of patients and on accurate early identification of non-responders. Patients...
Introduction:
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia of the elderly. Its early diagnosis is a clinical challenge due to overlapping symptoms of various neurodegenerative diseases. Early diagnosis is essential for patient management avoiding neuroleptic medications that harbor the risk of causing furthe...
Introduction:
Whole-body Positron Emission Tomography-Computerized Tomography (PET-CT) and pelvic Magnetic Resonance (MR) imaging are included in developed countries in the imaging algorithm of newly diagnosed cervical cancer (CC). In recent years, the novel technology of PET-MR has been introduced in the clinical practice of tumor imaging. We pre...
Introduction:
Accurate evaluation of the extent of disease in patients with prostate cancer is of great importance in guiding suitable treatment at all disease stages. Conventional imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), which rely on morphological criteria, are limited in assessing the real exten...
Purpose
Nationwide mass vaccination against Covid-19 started in Israel in late 2020. Soon we identified on [ ¹⁸ F]FDG PET-CT studies vaccine-associated hypermetabolic lymphadenopathy (VAHL) in axillary or supraclavicular lymph nodes (ASLN) ipsilateral to the vaccination site. Sometimes, differentiation between the malignant and benign nature of the...
Background[ ¹⁸ F]-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) may sometimes be suboptimal for imaging gastric adenocarcinoma. The recently introduced [ ⁶⁸ Ga]Ga-FAPI-04 (FAPI) PET/CT targets tumor stroma and has shown considerable potential in evaluating the extent of disease in a variety of tumors.Methods
We...
Purpose: Vaccine-associated hypermetabolic lymphadenopathy (VAHL) is frequently observed on [¹⁸F]FDG PET-CT following BNT162b2 administration. Recent data suggest a prominent B-cell germinal-center (GC) response elicited by mRNA vaccines in draining lymph nodes. Thus, in this study we aimed to explore the correlation between VAHL and humoral immuni...
Bone metastases from prostate cancer (PCa) often show an increase in density on computed tomography (CT) after successful androgen deprivation therapy (ADT). Density may be reduced, however, as the disease progresses or, contrarily, when disease is no longer active. The current study investigated the role of 68Ga-PSMA-11 positron emission tomograph...
Background
Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)–targeted positron emission tomography/computed tomography (PET/CT) reportedly has greater accuracy than conventional imaging for staging PC. As with any ima...
Purpose:
Over recent years, peptide receptor radiotherapy (PRRT) has been recognized as an effective treatment for patients with metastatic neuroendocrine tumors (NETs). Personalized dosimetry can contribute to improve the outcome of peptide receptor radiotherapy (PRRT) in patients with metastatic NETs. Dosimetry can aid treatment planning, ensuri...
![Fig. 2. [18F] FDOPA PET scans of two patients who presented with tremor...](profile/Jonathan-Kuten/publication/344428068/figure/fig2/AS:941388107640834@1601455823054/18F-FDOPA-PET-scans-of-two-patients-who-presented-with-tremor-and-referred-for_Q320.jpg)
Autonomic involvement, including cardiac denervation, may precede the motor symptoms of Parkinson’s disease by several years. L-3,4-dihydroxy-6-[18F] fluoro-phenylalanine is a positron emitter and a true analog of L-dopa, used in clinical practice to assess striatal dopaminergic integrity. The present study aimed to assess the feasibility of evalua...
Movement disorders represent a common clinical feature in many different neurologic diseases. However, although the clinical features are often similar, there are many different possible etiologies of these movement disorders, which represent a valid diagnostic challenge. Management of these patients is dependent on an accurate diagnosis of the und...
18F-PSMA-1007 is a novel prostate-specific membrane antigen (PSMA)-based radiopharmaceutical for imaging prostate cancer. The aim of this study is to compare the diagnostic accuracy of 18F-PSMA-1007 with 68Ga-PSMA-11 PET/CT in the same patients presenting with newly diagnosed intermediate and high-risk prostate cancer. Methods: Sixteen patients wit...
Background:
Whole-body integrated positron emission tomography / contrast-enhanced computed tomography (PET/CT) scan is increasingly used in cutaneous lymphomas. However, the value of PET/CT in the detection of cutaneous lesions in primary cutaneous B-cell lymphoma (PCBCL) has barely been investigated.
Objectives:
To investigate the diagnostic a...
Background:
The aim of the current study was to assess whether and to what extent monitoring response to treatment using prostate-specific membrane antigen (PSMA)-based positron-emitting tomography/computerized tomography (PET/CT) studies contribute clinically relevant data to routine clinical follow-up during treatment of patients with metastatic...
Introduction:
Data on the accuracy of 68Ga-PSMA positron emission tomography/computed tomography (PET/CT) in patients with intermediate/high-risk prostate cancer are being accumulated. Its role in assessing the extent of local disease has not been fully elaborated.
Aim:
To determine the performance characteristics of 68Ga-PSMA PET/CT in identify...
Introduction:
Sentinel node biopsy for axillary staging in node positive patients after neoadjuvant treatment is controversial, mainly due to high false negative rates. We examined the concordance between the location of the hot nodes identified on PET-CT at presentation with the location of the sentinel nodes.
Materails and methods:
Fifty-eight...
Background:
Ga-prostate-specific membrane antigen positron emission tomography/computerized tomography (Ga-PSMA PET/CT) is part of the initial workup of patients with intermediate and high-risk prostate cancer provided by the Israeli national health services.
Objectives:
To assess the incidence of metastatic spread in consecutive patients with n...
Comparison of NPAIRS with Canonical Variates Analysis (CVA) and the Scaled Subprofile Model approach (Eidelberg et al., 1994).
Background
The development of therapeutic interventions for Parkinson disease (PD) is challenged by disease complexity and subjectivity of symptom evaluation. A Parkinson's Disease Related Pattern (PDRP) of glucose metabolism via fluorodeoxyglucose positron emission tomography (FDG-PET) has been reported to correlate with motor symptom scores and m...
Background:68Ga-Prostate Specific Membrane Antigen (68Ga-PSMA), a positron emission tomography (PET) tracer that was recently introduce for imaging of prostate cancer, may accumulate in other solid tumors including Hepatocellular Carcinoma (HCC). The aim of the study was to assess the potential role of 68Ga-PSMA PET-Computed Tomography (CT) for ima...
Scintigraphy plays a major role in assessment of malignant bone involvement in cancer patients. Imaging is aimed to identify skeletal involvement as early as possible, to determine the extent of skeletal disease and to monitor response to therapy. Modern scintigraphic systems are integrated with CT. The combined functional-morphological fused data...
Identification of early changes in Dopamine-Transporter (DaT) SPECT imaging expected in the prodromal phase of Parkinson’s disease (PD), are usually overlooked. Carriers of the G2019S LRRK2 mutation are known to be at high risk for developing PD, compared to non-carriers. In this work we aimed to study early changes in Dopamine uptake in non-manife...
The scope of the current article is the clinical role of gamma cameras dedicated for breast imaging and 99mTc-MIBI tumor-seeking tracer, as both a screening modality among a healthy population and as a diagnostic modality in patients with breast cancer. Such cameras are now commercially available. The technology utilizing a camera composed of a NaI...
Background:
Assessment of residual disease after neoadjuvant therapy for breast cancer is an ongoing challenge of breast imaging. This study evaluates the accuracy of a novel dedicated system for molecular breast imaging (MBI) composed of the new generation of cadmium zinc telluride detectors in assessing residual disease after neoadjuvant therapy...
Follicular lymphoma (FL) is the 2nd most common type of lymphoma diagnosed in the Western World. Bone marrow (BM) involvement is an adverse prognostic factor in FL, routinely assessed by an arbitrary biopsy of the iliac crest. This study was aimed to investigate the role of positron emission tomography/computed tomography (PET/CT) in identifying BM...
Background:
Cadmium zinc telluride (CZT) solid-state detectors have been recently introduced in the field of nuclear medicine in cardiology and breast imaging. The aim of the current study was to evaluate the performance of the novel detectors (CZT) compared to that of the routine NaI(Tl) in bone scintigraphy. A dual-headed CZT-based camera dedica...
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third cause of cancer-related death worldwide. Orthotropic liver transplantation (OLT) and resection are curative treatment options for well-selected patients with HCC, while loco-ablative therapy has been shown to prolong survival. Organ and treatment allocation for these patie...
Nuclear medicine has been i nvolved in the field of functional tumor imaging for decades. Its hallmark is the detection of viable tumor tissue based on functional and biological characteristics rather than on an altered tumor morphology. Scintigraphy has an important role in monitoring the response to therapy, by distinguishing active tumor mass, w...
Production of (18)F-labeled tracers, including (18)F-fluoride, has been simplified, and bone imaging using (18)F-fluoride PET with computed tomography (PET/CT) is relevant once again. (18)F-Fluoride PET/CT imaging should be considered for the assessment of bone abnormality in clinical practice, not only in patients with cancer but also in benign sc...
Chronic knee pain is a common complaint among the elderly and appears in 30%–40% of the population over the age of 65. This study was performed in order to evaluate correlation between clinical presentation of chronic knee pain and the imaging findings of SPECT and planar bone scintigraphy. Methods. We prospectively recruited 116 patients over the...
Positron emission tomography/computed tomography (PET/CT) is an important tool in oncology for assessment of disease extent and recurrence. Recognition of benign fluorodeoxyglucose (FDG) uptake promotes correct interpretation of imaging data. This study assesses the appearance of benign uterine leiomyomas (ULs) on PET/CT and evaluates possible horm...
PURPOSE
Cadmium Zinc Telluride (CZT) detectors are novel semi-solid detectors recently introduced in nuclear medicine as an alternative to routine NaI(Tl) detectors, potentially improving the energy and spatial resolution of scintigraphic images. Initial experience with this new generation of detectors includes heart and breast scintigraphy. The pu...
This article summarizes the normal biodistribution of 18F fluorodeoxyglucose in the pelvis, physiologic changes in the female reproductive system and benign adnexal and uterine lesions which may be associated with increased tracer uptake that should be appreciated when PET/CT studies of female patients, mainly those with gynecologic malignancies ar...
Data on the use of PET in women with genetic or familial high-risk for breast or ovarian cancer are scarce. Open issues include the complementary use of dedicated breast-PET scanners in patients at high-risk for breast cancer, the relation between pathological characteristics of cancer diagnosed in BRCA carriers and (18)F-fluorodeoxyglucose ((18)F-...
99mTc-methylene diphosphonate (99mTc-MDP) is the most commonly used bone radiopharmaceutical for scintigraphic assessment of skeletal abnormalities. The compound,
an analogue of pyrophosphate, is chemisorbed onto bone surface. Its uptake depends on local blood flow and bone turnover.
As little as 5–10% change in lesion to normal bone uptake ratio i...
Most malignant skeletal lesions initiate intramedullary. As the intramedullary malignant deposit enlarges, the surrounding
bone undergoes osteoclastic and osteoblastic activity. Tumor cells may destroy bone directly or produce mediators that stimulate
reabsorption by osteoclasts.1Based on the balance between the two processes, the radiographic appe...
18F-fluoride is a positron-emitting bone-seeking agent, the uptake of which reflects blood flow and remodeling of bone. Taking advantage of the favorable pharmacokinetic properties of the tracer combined with the high performance of PET technology, 18F-fluoride PET is a highly sensitive imaging modality for detection of benign and malignant osseous...
![Table 3 Radiation dosimetry for adults and children >5 years of age [30]](profile/Giuseppe-Viale/publication/26774188/figure/tbl2/AS:668511466704915@1536396962831/Radiation-dosimetry-for-adults-and-children-5-years-of-age-30_Q320.jpg)
The accurate diagnosis of a sentinel node in melanoma includes a sequence of procedures from different medical specialities (nuclear medicine, surgery, oncology, and pathology). The items covered are presented in 11 sections and a reference list: (1) definition of a sentinel node, (2) clinical indications, (3) radiopharmaceuticals and activity inje...
Twenty-two regular smokers (15+ cigarettes per day) were treated with bupropion and group therapy for 2 months. Subjects underwent positron emission tomography (PET) studies using measures of brain global and regional glucose metabolism (regional cerebral metabolic rates of glucose [rCMRglc]) with [18F]-Fluorodeoxyglucose (FDG) twice, after watchin...
In-line combined systems, single-photon emission computed tomography (SPECT)/computed tomography (CT) and positron emission tomography (PET)/CT, allow an instant generation of fused images of scintigraphy and CT data. The accumulated clinical data on the use of these systems in various clinical scenarios indicate that this hybrid technology improve...
Heavy use of marijuana is claimed to damage critical skills related to short-term memory, visual scanning and attention. Motor skills and driving safety may be compromised by the acute effects of marijuana. The aim of this study was to investigate the acute effects of 13 mg and 17 mg Delta 9-tetrahydrocannabinol (THC) on skills important for coordi...
Colorectal perforation is an emergent medical condition in which the diagnosis and the etiology are often established on CT, the common imaging modality used for evaluating the acute abdomen. The cardinal, direct CT features suggesting perforation are extraluminal air and enteric contrast, added by secondary signs of bowel pathology, such as focal...
Twelve regular users of marijuana underwent two positron emission tomography (PET) scans using [18F] Fluorodeoxyglucose (FDG), one while subject to the effects of 17 mg THC, the other without THC. In both sessions, a virtual reality maze task was performed during the FDG uptake period.
When subject to the effects of 17 mg THC, regular marijuana smo...
Radioguided surgery is a surgical technique that uses specific tissue characteristics (e.g., receptor or epitope expression,
increased metabolism, or protein synthesis) to mark tissue with a radionuclide before surgery. The surgeon then uses a radiation-sensitive
probe to define the tissue margins at the time of surgery.
The most commonly used positron emission tomography (PET) tracer in clinical practice, fluorine-18 fluorodeoxyglucose ( (18)F-FDG) is a glucose analogue that directly gains entry in excess into tumor cells. It is therefore sensitive for the detection of early bone marrow involvement prior to any identifiable bone changes. The introduction of (18)F-...
Bone metastases are the most common malignant bone tumors. Skeletal involvement varies in different human malignancies, with breast cancer being the leading cause for bone metastases in women and prostate cancer in men, followed by lung cancer. Bone is the first site of relapse in 50% of patients with breast cancer and in 80% of patients with prost...
(18)F-Fluoride is a positron-emitting bone-seeking agent, the uptake of which reflects blood flow and remodeling of bone. Assessment of (18)F-fluoride kinetics using quantitative positron emission tomography (PET) methods allows the regional characterization of lesions of metabolic bone diseases and the monitoring of their response to therapy. It a...
The objective of our study was to characterize benign lesions showing increased 18F-FDG uptake and to determine their incidence on whole-body FDG PET/CT performed in oncologic patients. In addition, the performance of PET alone and PET/CT in characterizing lesions as benign was compared.
A retrospective review of 1,134 consecutive reports of PET/CT...
The treatment of patients with regionally recurrent papillary carcinoma of the thyroid is a matter of controversy. Radioactive nodal picking was proposed as an alternative to neck dissection in these patients.
We analyzed neck dissection specimens in 20 patients with PTC and compared the results to preoperative total-body scan (TBS) following a the...
Lymphoma may originate in extranodal sites. Extranodal lymphoma may also be secondary to and accompany nodal disease. Fluorine-18 fluorodeoxyglucose (18F-FDG) imaging has an essential role in the staging of lymphoma, in monitoring the response to therapy, and in detection of recurrence. The introduction of 18F-FDG PET/CT hybrid imaging allows for a...
The utility of preoperative and postoperative whole body integrated positron emission tomography-computed tomography (PET-CT) scanning for staging and follow-up in patients with skull base tumors is undetermined.
We prospectively evaluated PET-CT findings in 47 patients using 57 scans. Most (35/47, 75%) had anterior skull base tumors and the majori...
The use of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) in the field of oncology is rapidly evolving; however, (18)F-FDG is not tumor specific. Aside from physiological uptake (18)F-FDG also may accumulate in benign processes. Knowledge of these (18)F-FDG-avid nonmalignant lesions is essential for accurate PET interpretatio...
Recent data confirmed the importance of 18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in the selection of patients with colorectal hepatic metastases for surgery. Neoadjuvant chemotherapy before hepatic resection in selected cases may improve outcome. The influence of chemotherapy on the sensitivity of FDG-PET and CT in detecti...
Computed tomography (CT) is frequently used for postoperative evaluation in patients who have undergone splenectomy, on either an elective or an emergency basis. This pictorial article reviews and demonstrates the CT findings of postoperative anatomic changes, as well as various postoperative complications following splenectomy.
The purpose of this prospective study was to assess the role of SPECT/multislice low-dose (Msl) CT as a constituent in the imaging algorithm of nononcologic patients referred for 99mTc-methylene diphosphonate bone scintigraphy (BS).
SPECT/CT was performed using a novel hybrid system, which incorporates a gamma-camera and a multislice low-dose CT, o...
Overweight has been reported as a cause for the nonvisualization of sentinel nodes (SNs) on preoperative planar lymphoscintigraphy in patients with breast cancer. The purpose of this study was to assess whether SPECT/CT may improve SN identification in overweight patients.
Lymphoscintigraphy was performed in 220 consecutive patients with breast can...
The aim of the present study was to assess the ability of a novel bone imaging technique to diagnose accurately the cause for back pain as an isolated and presenting complaint in adolescents. An integrated 18F-fluoride positron-emission tomography-computed tomography (PET-CT) study was performed at the same setting without changing the patients' po...
The aim of the present study was to assess the ability of a novel bone imaging technique to diagnose accurately the cause for back pain as an isolated and presenting complaint in adolescents. An integrated 18F-fluoride positron-emission tomography-computed tomography (PET-CT) study was performed at the same setting without changing the patients' po...
PET imaging is based on the use of a biochemical molecule labeled with a positron-emitter (such as 18F, 11C, 15O) enabling in vivo tracking of the radioactive compound. During the decay process of the radioisotope, a positron is emitted, which after traveling a short distance (about a millimeter) encounters an electron from surrounding molecules. T...
We assessed the added clinical value of fused single photon emission computed tomography (SPECT) and low-dose CT images compared with planar images for sentinel node (SN) mapping in patients with oral cavity squamous cell carcinoma (SCC).
Twenty consecutive patients with newly diagnosed biopsy-proven SCC of the oral cavity were enrolled. Scintigrap...
Most prostate cancers are androgen dependent upon initial diagnosis. On the other hand, some very aggressive forms of prostate cancer were shown to have lost the expression of the androgen receptor (AR). Although the AR is routinely targeted in endocrine treatment, the clinical outcome remains suboptimal. Therefore, it is crucial to demonstrate the...
Malignant melanoma of the skin is one of the most lethal cancers. The disease may spread either locally or regionally and to distant sites through predictable or unpredictable metastatic pathways. Accurate staging and restaging of disease are required for appropriate treatment decision making. Routine protocols based on clinical examinations and tr...
To assess the role of 18F-Fluorodeoxyglucose (18F-FDG) PET/CT in pediatric patients with Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL).
31 patients, mean age 12.9 +/- 5.1, HD (n = 24), and NHL (n = 7) underwent 18F-FDG PET/CT at diagnosis (n = 31 studies) and later in the course of the disease (n = 75 studies). The findings of PET/CT were cor...
Application of an in-line positron emission tomography and computerized tomography (PET-CT) in endodermal sinus tumor (EST) is described in this study. CASE 1: A young female with massive ascites postovarian mass resection had elevated alpha-fetoprotein (AFP) serum levels. Following a positive PET-CT study with increased (18)F-fluorodeoxyglucose (F...
Application of an in-line positron emission tomography and computerized tomography (PET-CT) in endodermal sinus tumor (EST) is described in this study. Case 1: A young female with massive ascites postovarian mass resection had elevated alpha-fetoprotein (AFP) serum levels. Following a positive PET–CT study with increased ¹⁸ F-fluorodeoxyglucose (FD...
The purpose of the study was to determine the general and organ-specific presentation of incidental primary tumours on PET-CT.
PET-CT reports of 2,360 consecutive patients were reviewed and revealed 156 lesions suspicious for a new unexpected malignancy, in 151 patients. One hundred and twenty of these lesions, in 115 patients, were further assesse...
Citations
... Nevertheless, it is important to underline that the mentioned findings on the role of [ 18 F]FDG are based on the analyses of the accumulated clinical data in PCa patients rather than the analyses of the mechanism of NEPC. In this setting, this tracer cannot differentiate neuroendocrine differentiation from complex PCa cases by only relying on tumor uptake mechanism, and cases of positive PET/CT scans have been mainly described in treatment-induced NEPC [43]. Generally speaking, it has been reported that neuroendocrine differentiation is not always associated with [ 18 F]FDG uptake, and moreover, PET/CT with this radiopharmaceutical is usually performed for high-grade and poorly differentiated forms of neuroendocrine neoplasms [3,44,45]. ...
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... The potential impact of consolidated tracers in the management of cancer patients should not be underestimated; interesting data are emerging from the application of radiomics to PET imaging, with 18 F-fluoroethylcholine in prostate cancer imaging [18] or 18 F-DOPA in movement disorders [19]. The other contributions of this Special Issue offer direct insight into a wide range of new molecular pathways-such as hypoxia imaging and the 68 Ga-Fibroblast-Activation Protein Inhibitor-novel hybrid chelators, and new synthesis methods through an experimental approach; however, there is still a lack of knowledge on the potential benefits and pitfalls emerging from routine use of the proposed tracers, which should be assessed in different clinical settings. ...
... Recent studies have begun to show that it is also valuable in treating lymphoma, liver, and breast cancer [7][8][9]. When it comes to finding lymph node metastases and faraway metastases, PET/MRI is also superior to CT, MRI, and PET/CT, as PET/MRI can provide dynamic enhanced imaging, diffusion-weighted imaging (DWI), and signal strength (SI) assessment that can display non-fluorodeoxyglucose (non-FDG) uptake lesions and avoid misdiagnosis of sites with physiologic FDG uptake, such as the adrenal glands and mucous membranes [10][11][12][13]. ...
Reference: The use of PET/MRI in radiotherapy
... for manual measurements) [42][43][44][45][46] . Recent NM-MRI studies demonstrated nigral NM damage in LRRK2-associated PD patients 47,48 . Although similar studies validated in several cohorts will help better understand whether nigral neurodegeneration mechanism is similar in genetic and idiopathic PD. ...
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... 12,13 Additionally, 14 more studies are currently available on this subject, encompassing a total of 591 patients. 4,5,[14][15][16][17][18][19][20][21][22][23][24][25] Most of these studies have primarily focused on nodal staging. Compared to conventional imaging, PSMA PET/CT demonstrates higher sensitivity in detecting pathological nodes. ...
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... [ 18 F]-Fluorodeoxyglucose (FDG)-PET has a well-recognized role in the staging, restaging, and therapy response assessment in patients with lymphomas including patients candidate for or treated with CAR-T. [17][18][19][20][21][22][23][24][25] At present, both in trials and clinical practice, whole-body [ 18 F]FDG PET is performed before and around 30 days after treatment with CAR-T. 1,[17][18][19][20][21][22][23][24][25] Preliminary data have linked the metabolically active tumor burden as measured with PET with the risk of developing CRS. ...
... (5,13) Radiographic presentations may vary, as well as their clinical presentation. (14) There are Patients with MALT lymphomas have better prognosis compared with those with high grade lymphomas. (12) In most cases, the diagnosis is made after nephrectomy, generally due to suspicion of another oncological lineage, and most of these patients do not require additional treatment. ...
... However, other types of metastases occur. In a recent study of 963 prostate cancer patients, 188 patients (19.5%) demonstrated skeletal metastases [23]. Out of these, 70.7% demonstrated osteoblastic type metastases, whereas intramedullary metastases were found in 51.6% of the patients, and osteolytic metastases were detected in 36 patients (19.2%). ...
... Cohen et al. reported that the duration of FDG uptake was shorter after the third vaccination and lower after the rst ve days (30). The immune response mechanism is thought to be related to the shortened reaction duration after the third vaccination. ...
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... After removing 35 duplicates, 92 titles and abstracts were screened, with the majority of the articles not aligning with the study's objectives, primarily focusing on CAR T-cell therapeutic efficacy. Ultimately, only 17 articles met the criteria for inclusion and were further evaluated after retrieving the full-text versions [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. An additional study [42] was found during the cross-reference check, bringing the total number of qualified studies to 18 for further analysis (Figure 2A). ...
