Eileen Schormann's research while affiliated with Charité Universitätsmedizin Berlin and other places
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Publications (3)
Microglia are the resident immune cells of the central nervous system (CNS) and play a major role in the regulation of brain homeostasis. To maintain their cellular protein homeostasis, microglia express standard proteasomes and immunoproteasomes (IP), a proteasome isoform that preserves protein homeostasis also in non-immune cells under challengin...
The immunoproteasome (iP) represents a specialized type of proteasomes, which plays an important role in the clearance of oxidant-damaged proteins under inflammatory and pathological conditions determining the outcome of various diseases. In Alzheimer's disease (AD)-like APPPS1 mice Aβ-deposition is paralleled by iP upregulation, most likely mediat...
Aims: Precise regulation of cellular protein degradation is essential for maintaining protein and redox homeostasis. The ubiquitin proteasome system (UPS) represents one of the major degradation machineries, and UPS disturbances are strongly associated with neurodegeneration. We have previously shown that the transcription factor TCF11/Nrf1 induces...
Citations
... While proteasome-mediated suppression of inflammatory/immune responses might be an evolutionarily conserved phenomenon, the exact mechanisms of how immune responses are kept in check are likely to differ. For example, activation of type-I interferon signaling in mammals as a consequence of proteasome dysfunction has been attributed to ER stress and activation of the unfolded protein response (UPR) [28,50,51]. This is unlikely to be the case in the context of oomycete recognition as we have previously shown that introducing ER stress does not induce chil-27p::GFP [2]. ...
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... The reduction in GFAP and Iba1 cells in the APP/PS1 FK506-treated mice (Fig. 3D), suggested the cytokine expression would be reduced. As previously published, cortical levels of interferon gamma (IFNγ), IL-6, IL-5, IL-10, IL12p70, IL-1β, and TNF-α were all increased in the APP/PS1 mice in comparison to WT mice ( Fig. 4A-H) [56][57][58]. After 3 months of treatment IFNγ, IL-6, IL-5, IL-10, and IL12p70 were all reduced to the levels seen in the untreated WT mice (Fig. 4A-E). ...
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... Variation Society (HGVS) [37]. For structural analysis, mature 20S subunit protein sequences containing a substitution of interest were subjected to folding using preprint (which was not certified by peer review) is the author/funder. ...
