Edgar G. Harrison's research while affiliated with Mayo Clinic - Rochester and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (98)
Interstitial pneumonitis in children is a rare and poorly understood disease. Controversy exists as to whether the varoius histologic changes encountered represent different disease or a spectrum of the same disease. Fourteen biopsy-confirmed cases of desquamative interstitial pneumonitis in children were seen at the Mayo Clinic between 1953 and 19...
Li, Chin-Yang, and Harrison, Edgar G., Jr.: Histochemical and immunohistochemical study of diffuse large-cell lymphomas. Am J Clin Pathol 70: 721–732, 1978. Ninety diffuse large-cell lymphomas (diffuse histiocytic lymphoma) were sub-classified into B-cell, T-cell, and histiocytic types according to their enzyme histochemical and immunohistochemical...
In the absence of a prospective randomized study of patients treated conservatively or with thymectomy, a computer-assisted retrospective matches study was devised. Of 563 patients treated for myasthenia gravis without thymoma up to 1965, 104 had thymectomy. With computer assistance, each surgical patient was matched with a medical patient on the b...
Ninety-four patients with lymphoma involving the extradural space with spinal cord compression proven at the time of laminectomy were reviewed. There were about three times as many patients with non-Hodgkin's lymphoma than with Hodgkin's disease. The majority of those with Hodgkin's disease had a proven histologic diagnosis before the onset of the...
In the absence of a prospective randomized study of patients treated conservatively or with thymectomy, a computer-assisted retrospective matched study was devised. Of 563 patients treated for myasthenia gravis without thymoma up to 1965, 104 had thymectomy. With computer assistance, each surgical patient was matched with a medical patient on the b...
Confusion surrounds the entity known as “lethal midline granuloma.” Partly responsible is the lack of specificity in this term. “Polymorphic reticulosis” has been used as a term to describe the morphology of the disease.
Thirty-two cases illustrate the protean features of this disease. Although it commonly presents in the head and neck, other sites...
An unusual syndrome of hepatosplenomegaly and fever followed by rapid deterioration and death has been described in 38 children from 21 families. Pancytopenia, liver dysfunction, and bleeding developed prior to death from hemorrhage, sepsis, or lymphocytic meningitis. This report reviews the literature and adds a set of twins to the reported cases.
Forteen cases of angioimmunoblastic lymphadenopathy were reviewed retrospectively, and histologic material was examined by various staining and histochemical techniques. The predominant morphologic features were effacement of nodal architecture, microvascular proliferation, and a polymorphous cellular infiltrate of immunoblasts, plasma cells, lymph...
A retrospective study of 116 children with Hodgkin's disease diagnosed in the period 1935-1970 was undertaken to assess the prognostic role of histopathologic classiciation and clinical extent of the disease. The ages of the 80 boys and 36 girls ranged from 2.5 years to 15.0 years (mean, 10.0 years). The histopathologic diagnosis by lymph node biop...
An 11-year-old girl presented with a refractory hypochromic microcytic anemia, hypoferremia, normoblastic hyperplastic bone marrow, hypergammaglobulinemia, and growth retardation. Many varied treatments failed to produce any improvement. Ferrokinetic studies revealed rapid plasma clearance and increased plasma iron turnover, but impaired incorporat...
Lobular carcinoma may arise within the epithelial component of fibroadenoma of the breast, as evidenced by 5 cases reported from the files of the Mayo Clinic and 21 cases cited in the literature. The 5 cases reported here occurred in a series of 4000 cases of fibroadenoma during a 43-year period. Lobular carcinoma is the more frequent type to be se...
Granular cell myoblastoma (Abrikossoff's tumor), although certainly a rare, almost always benign lesion, is being encountered with increasing frequency in areas of particular interest to the otolaryngologist or surgeon in the upper aerodigestive tract. Although such lesions have been found frequently in the oral cavity and larynx, only one case has...
Clinically and grossly, an inflammatory fibrous polyp of the ileum may resemble an ulcerated polypoid carcinoma and may produce intussusception or partial bowel obstruction. Only eight cases of this distinctive lesion have been reported in the literature; the findings in these cases and in three new cases discussed here.
Pleural effusion in lymphoma is usually, but not invariably, a poor prognostic sign. The presence of underlying parenchymal lung involvement or a chylous type of effusion does not further alter the prognosis, but the presence of malignant cells in the fluid probably shortens survival. Obstruction of lymphatic drainage of the lung and pleura by enla...
A father and his daughter, both suffering from the Gardner syndrome, came to our attention at the same time with symptoms produced by primary carcinoma of the duodenum. Duodenal polyps were also present. Studies of these and other patients with similar features strongly suggest that these lesions may be a part of this inherited condition. Roentgeno...
From the medical records of the Mayo Clinic and other institutions providing medical care to local citizens, 167 cases of malignant lymphoma were identified and 164 were confirmed by tissue examination. The average annual incidence rates for all types of nodal lymphoma in Olmsted County showed no significant change for the 25 years of study; there...
At the Mayo Clinic during a thirty-year period, 31 patients (25 men and 6 women) underwent exploratory thoracotomy and pulmonary resection for unsuspected pulmonary infarction. Cough, hemoptysis, or pleuritic pain was present in approximately half the patients. Most patients underwent exploration for a suspected neoplastic process. Pathologically,...
The records of 81 patients with a roentgenologic pattern of diffuse reticulonodular pulmonary disease and a pathologic diagnosis of chronic interstitial pneumonitis and fibrosis were reviewed. All had restrictive patterns on pulmonary function testing with impairment of CO diffusing capacity. The most common features were characteristic dry rales,...
The clinicopathologic findings in ninety cases of carotid body tumors seen at the Mayo Clinic from 1931 through 1966 are compared with those in 500 reported cases in the literature. In the ninety cases reviewed here, there were sixty-two men and twenty-eight women. In twenty cases surgery had been performed elsewhere; seventy patients were operated...
The clinicopathologic findings in ninety cases of carotid body tumors seen at the Mayo Clinic from 1931 through 1966 are compared with those in 500 reported cases in the literature. In the ninety cases reviewed here, there were sixty-two men and twenty-eight women.
Infectious mononucleosis (IM) may be diagnosed clinically, or, since lymphadenopathy is a major feature, lymph node biopsy may be performed to establish the diagnosis. However, in 5 of 11 cases in which lymph node biopsies were obtained, the initial histopathologic examination suggested lymphoma or Hodgkin's disease. The histopathologic or clinical...
The prognosis for lymphoma clinically localized to the testis at the time of original diagnosis is relatively favorable after orchiectomy and radiation therapy to the regional lymph nodes the previously held belief that life expectancy is poor for men with testicular lymphoma was due to failure in most reports to separate survival of those with loc...
Studies as clinically warranted were accomplished in more than 2,000 patients seen from January 1964 through December 1968 because of hypertension and suspected or proved renal disease. Data from the clinical history, physical examination, laboratory investigation and results of surgical or medical treatment are reported for 100 cases each of 5 ent...
A patient with Hodgkin's disease (Stage IIB) was given nitrogen mustard shortly after diagnosis and has survived, without recurrence, for more than 5 years.
The records of 1,500 patients with Hodgkin's disease seen at the Mayo Clinic from 1950 to 1967 were reviewed in search of any later-developing myelo-proliferative disorders. No cases of polycythemia vera, agnogenic myeloid metaplasia, or primary thrombocythemia were found in patients with pre-existent Hodgkin's disease. Three case reports of myelom...
A paraganglioma of the glomus-jugulare region secreted norepinephrine and produced episodes of short-lived headache and palpitation similar to those seen in pheochromocytoma. The preoperative determination of excessive norepinephrine secretion permitted pharmacologic blockade by phenoxybenzamine and a smooth operative course. Until the true frequen...
The data from 32 cases of angiomyolipoma (renal hamartoma) are presented: 23 of the tumors were removed at surgery and nine at autopsy. The histopathologic findings are reviewed and the spectrum of gross renal involvement is emphasized. On the basis of the duration of symptoms and findings and the subsequent course of patients subjected to surgical...
Initial biopsies of cervical, supraclavicular and axillary lymph nodes from 185 adults with lymphoma who did not have the anatomical distribution of Burkitt's lymphoma were reviewed. All patients were seen at the Mayo Clinic between 1952 and 1964. A “starry sky” appearance (marked histiocytic phagocytosis) was present in 18% of the 85 immature (lym...
Five cases of verrucous carcinoma of the esophagus have been presented. This is a previously unreported location for this distinct morphologic variant of squamous cell carcinoma, which apparently may occur on any stratified squamous mucosa or modified skin. The tumor in the esophagus is morphologically similar to this tumor in other parts of the bo...
Osteochondroma (tracheobronchial choristoma) of the esophagus is a rare tumor. Survey of the literature revealed only one reported case in which an esophageal osteochondroma was known to have been removed during the patient's life. The case reported herein is another one of an esophageal osteochondroma that was successfully removed surgically. The...
This paper presents a review of the recent literature on primary macroglobulinemia (Waldenström) and a report on thirty-one patients, including ten patients personally treated with chlorambucil over a period of seven years as well as three others followed closely. The course of the disease was categorized in several types: asymptomatic, delayed-pro...
The arterial pathology in sixty-six cases of renovascular hypertension due to idiopathic, nonatherosclerotic disruptive and hyperplastic lesions predominantly of the media of renal arteries has been designated under the general category of fibromuscular dysplasia. These lesions usually affected young adults, although their ages ranged from six to s...
From 1933 through 1962 thirty-three patients who had nasal lymphoreticular lesions previously diagnosed as lymphoma were seen at the Mayo Clinic. Of the thirty-three patients twenty-three were men and ten were women. Their ages ranged from twenty-five to seventysix years and 70 per cent were more than forty years of age. The most frequent complaint...
The types of malignant anal and perianal neoplasms are reviewed. Factors affecting the choice of treatment and the survival
in these cases include the type of malignant tumor, degree of anaplasia, stage of infiltration (including presence or absence
of metastasis), and size and location of the lesion in relationship to the pectinate line. The final...
Transbronchoscopic lung biopsy, in our opinion, can be a useful adjunct in the diagnosis and management of patients with diffuse pulmonary disease. Lung biopsy through the bronchoscope was attempted in 13 patients and pulmonary tissue way obtained from 11. In each of the 11 cases, microscopic examination of lung tissue was helpful in diagnosis and...
In 70 cases of granulomatous prostatitis 54 (77%) mimicked carcinoma clinically. Granulomatous prostatitis is a distinct clinical and pathological entity, apparently a reaction to extravasated prostatic secretions into the surrounding tissues secondary to obstruction and infection within the prostate. In about 80% of the patients, there was a triad...
A case of renal arteriovenous fistula is presented in which radioisotope renography and differential studies of renal function strongly suggested the presence of ipsilateral renal ischemia, subsequently confirmed. Another case, due to hypernephroma, is described in which aorticorenal arteriography revealed vascular lakes within the tumor, together...
THE OF chemotherapeutic agents as adjuvants in palliative treatment for malignant tumors in other parts of the body suggested that perhaps beneficial effects could be obtained in lesions involving the head and neck. Although the specificity of these various compounds for certain types of cancer has already been demonstrated in leukemia, lymphoma, a...
This chapter describes the synthesis and properties of tranylcypromine sulfate. The particle morphology of tranylcypromine sulfate was studied using polarizing optical microscopy. The chapter discusses the absorption and distribution of tranylcypromine sulfate. Tranylcypromine is readily absorbed after oral administration and is extensively metabol...
A 71-year-old man who had practiced snuff dipping (placing a small amount of tobacco snuff in the gingivobuccal groove and leaving it there for extended periods of time) for 40 years had a shaggy white tumor which occupied the posterior surface of the lower lip, replaced the alveolar process, and filled much of the floor of the mouth. Examination o...
Five cases of allergic granuloma of the prostate occurring exclusively in asthmatic patients have been reported in detail. The lesions are characterized histologically by areas of fibrinoid necrosis within histiocytic granulomas with an intense eosinophilic infiltration. The cause is unknown, although the condition is considered to be the result of...
A syndrome characterized by multiple nevoid basal cell epitheliomas of the skin, cysts of the jaw, and congenital skeletal deformities has been studied and a series of new cases reported. Manifestations of the syndrome occur early in life, often in childhood, and there are definite familial or hereditary tendencies but no sex predilection. Some of...
When a physician sees a patient with lymphedema he must determine whether the lymphedema is idiopathic or secondary to an obstructive or inflammatory process. In the majority of the 131 cases of idiopathic lymphedema in the series studied, swelling began before the age of 39 years. Onset later, therefore, should alert the physician to the possibili...
In 316 cases of abdominal cysts seen at the Mayo Clinic between 1911 and 1959 there were 23 cases of chylous cysts, an incidence of 7.3 per cent, 11 of which were reported previously. In the 12 new cases which are reported, 9 patients were considered to have chylous cystic lymphangiomas (chylangiomas) and 3 had acquired chylous cysts which develope...
A MASS presenting in the anterolateral aspect of the neck is always a problem in clinical diagnosis. Last among the possibilities considered is chemodectoma (nonchromaffin paraganglioma) —and particularly vagal-body tumor — because of its rarity as compared with the several other kinds of tumors that may appear in the neck. A chemodectoma presentin...
Angiosarcoma of the breast is distinctly rare. We found only 20 well-documented cases cited in the literature. To this number we have added 2 cases. The first is that of a 47-year-old woman who was treated surgically for metastasis from a mammary tumor and who subsequently died with metastasis 50 months after onset of the disease. The other case is...
A study was made of seventy-seven patients with squamous cell carcinoma of the buccal mucosa (cheek) treated at the Mayo Clinic from 1945 through 1954. All patients who received any form of treatment were included.A five-year survival rate of 50 per cent of the patients who were followed up was obtained.An attempt was made to determine the most eff...
Pulmonary alveolar proteinosis, apparently a new disease, is being encountered with increasing frequency. Clinically, progressive dyspnea is a common feature, and its severity is often at variance with the extent of the roentgenographic changes, which frequently resemble those of pulmonary edema. Pathologically, the alveoli are filled with a dense...
Citations
... 1,2 Most leiomyomas are found to originate from the inner circular muscle layer of the distal oesophagus (60% of cases) with maximum incidence found amongst middle aged male. [3][4][5][6] Tumours larger than 10 cm are called Giant Leiomyomas and may be single or multiple. 7,8 Leiomyomas are often misdiagnosed as mediastinal mass, oesophageal cancer and gastrointestinal stromal tumour (GIST). ...
... Eneroth and associates, 3 in their study of nasal hemangiopericytomas, have emphasized local recurrence and late metastasis, along with an absence of specific age predilection, and have recommended radical surgical procedures to effect cures. Other studies 10 have suggested a more benign course. Our studies have shown these vascular neoplasms to be lesions of only local consequence that can be effectively controlled with adequate local excision. ...
... 2,9,10 In the Remine et al. study, one group of patients with metastatic pheochromocytoma had a relatively high mortality rate within 5 years of metastasis, while another group had a maximum survival time of up to 20 years after being diagnosed with metastatic tumors. 11 Lumbar metastasis of adrenal pheochromocytoma is very rare, and less than 10 cases have been reported as far as we know. It has been reported that for those patients, only surgical resection of metastatic lesions without any adjuvant therapy can increase survival for up to 26 years. ...
... SCCP is a rare neoplasm that accounts for Ͻ 0.5% of all male cancers. 34 Risk factors for the development of SCCP include tobacco use, delayed or lack of circumcision, and a past history of genital warts. 35 The patient described here presented with all three of these predisposing conditions. ...
... 148 However, because of the possible confusion with urothelial carcinoma, authors reported more extensive surgical procedures in 24.8% of cases, such as nephro-ureterectomy, 5,32, 38,40,44,49,51,54Y56,59,65,73,85,92,99,100,104,106,114,118,124,130,138,143,144, 152,159,162,163 or partial or complete cystectomy. 3,68,79,98,99,141 Surgical reconstruction was performed to preserve integrity of the urinary tract, particularly in patients with a solitary functioning kidney. 15,16,23,40,53,58,62,63,69,90,91,95,98,146,149,153,160 Hemodialysis was also necessary when the tumor involved both ureters or a solitary functioning kidney, and when the patient presented anuria or acute renal failure. ...
... 14 True histiocytic lymphomas are extremely unusual in humans, accounting for about 1% of all nodal non-Hodgkins lymphomas. 8 However, extranodal histiocytic sarcoma may be more common. 4,51 Although certain features, including abundant eosinophilic cytoplasm, lobulated nuclear contours, and occasional evidence of phagocytosis, may suggest the monocyte/macrophage lineage of a tumor, such morphologic features are highly unreliable in predicting the immunologic phenotype. ...
... Identifying CBTs relies primarily on their specific location at carotid bifurcation, which leads to the splaying of carotid vessels, as well as the hyervascularity nature of CBTs (4). However, CDU was reported to have lower sensitivity in detecting CBTs (5), as well as poorer accuracy in characterizing the size of the lesion areas and Shamblin type of CBTs (6,7) than computed tomography angiography (CTA). CTA, however, although widely accepted as the initial diagnostic tool of CBTs (4,8), poses the risk of adverse effects, including exposure to ionizing radiation and nephrotoxicity from iodinated contrast material, and is unsuitable for vulnerable populations such as pediatric patients, pregnant patients, or those with chronic renal disease. ...
... Синонимом названия этих образований является термин «нехромаффинная параганглиома». Параганглионарная система широко представлена в различных органах и тканях человека в виде рассеянных и собранных в клубочки клеток, связанных с ганглиями [1,2,5,6,16,18,30]. Термин параганглиома был впервые использован Kohn в начале ХХ века и является наиболее подходящим наименованием с точки зрения эмбриологии [1,2,18,23,27,30,31,35]. ...
Reference: Surgical treatment of carotid chemodectomas
... Fibromuscular Dysplasia (FMD) is a rare noninflammatory, nonatherosclerotic vascular disease seen in less than 0.4% of the population that primarily affects medium to small sized arteries [1,2]. FMD is classified into two subtypes, multifocal and focal. ...
... The thymus is pathologically abnormal in 80 to 90 % of MG patients, with thymic hyperplasia being present in 50 to 60 % of the cases and thymoma in 10 to 15 % of the cases [29]. Significant clinical improvement is often observed following thymectomy [30]. The incidence of thymus abnormalities is less frequent in seronegative than in seropositive MG patients [2,31]. ...
