E De Luna's research while affiliated with Ospedale Ordine Mauriziano di Torino, Umberto I and other places
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Publications (2)
Introduction:
We evaluated analytical and clinical performances of IgG and IgM anticardiolipin (aCL) antibodies and anti-β2-glycoprotein I (a-β2GpI) antibodies and upper limit reference ranges (99th percentiles) in comparison with manufacturer's cutoff values with different commercial methods.
Methods:
We assayed aCL and a-β2GpI in serum samples...
Laboratory tests for anticardiolipin antibodies (aCL) and anti-β2glycoprotein I antibodies (a-β2GPI) face problems common to many autoantibody assays: the lack of a reference standard and the need for each laboratory to assess assay-specific cut-off values. The aims of the study were to evaluate the reference range upper limits (99th percentile) us...
Citations
... Both types of antibodies (aβ2GPI and aCL) are determined by solid-phase immunoassays, either by ELISA, FIA or CLIA methods, including multiplex immunoassays (8,(46)(47)(48). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273601536692264-1442243098002_Q64/Cristiana-Marchese.jpg)
... El problema científico principal radica en que el criterio de laboratorio basado en aCL y anti-2GPI para el diagnóstico del SAF es poco preciso, además, se ha visto variación en diferentes poblaciones, tanto en los rangos de referencia obtenidos con los kits comerciales como en los valores pautados por los criterios clasificatorios 19 . Esta puede ser una explicación para los resultados discordantes encontrados. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/280465073295368-1443879492840_Q64/Giulio-Mengozzi.jpg)
