Med's research while affiliated with University of Bristol and other places
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Publications (3)
Inflammation of the equine tracheobronchial tree is a result of infection, allergy, and environmental contamination. Acute bouts of inflammation cause mucus secretion, airway wall thickening, and increased responsiveness of reflexes that initiate cough and bronchospasm. Recurrent bouts of inflammation lead to structural changes in the mucosa and th...
The tracheobronchial tree delivers and distributes air within the lung. Normally it provides a low resistance to airflow. Airway smooth muscle, the mucociliary system, the bronchial circulation, and cough provide neurally mediated protection of the lung from environmental challenges. Disease involves an exaggerated response of these mechanisms so t...
The pharmacological management of tracheobronchial disease primarily involves the use of bronchodi-lators and anti-inflammatory agents. The most useful bronchodilators are quaternary ammonium anticholinergics, such as ipratropium, and 2 -adrenergic agonists. Bronchodilators are most effective when delivered as aerosols by one of the newer devices d...
Citations
... Corticosteroids -Given the current state of knowledge relating to IAD, glucocorticoids should be considered one of the core therapies for this syndrome. Much information relating to use of corticosteroids in respiratory disease comes from studies in horses with heaves [139]. However, as mentioned previously, it remains unproven as to whether horses with IAD suffer the same pathophysiological responses to airway inflammation as those with heaves. ...
Reference: Inflammatory Airway Disease ( 16-Aug-2002 )
... Young racehorses in training suffer from IAD, a condition that also involves airway neutrophilia and increased amounts of tracheal mucus [11,12,13,14]. Clinical signs of IAD include coughing [11,12] and poor racing performance [15,16,17,18,19]. We have shown previously that Muc5b and Muc5ac are the predominant mucins in airway secretion from healthy horses [20]. ...
