Dinorah Friedmann's research while affiliated with Hebrew University of Jerusalem and other places

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Publications (2)

FIGURE 3. Nucleotide and deduced amino acid sequences of H (A) and L...
FIGURE 3. (continued)
FIGURE 4. V gene utilization by V H 11 transgenic anti-DNA hybridomas,...
FIGURE 5. 
Production of High Affinity Autoantibodies in Autoimmune New Zealand Black/New Zealand White F1 Mice Targeted with an Anti-DNA Heavy Chain
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  • May 1999
Lupus-prone, anti-DNA, heavy (H) chain "knock-in" mice were obtained by backcrossing C57BL/6 mice, targeted with a rearranged H chain from a VH11(S107)-encoded anti-DNA hybridoma (D42), onto the autoimmune genetic background of New Zealand Black/New Zealand White (NZB/NZW) F1 mice. The targeted female mice developed typical lupus serologic manifest...
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FIGURE 1. 
FIGURE 2. Representative flow cytometric analysis of B cells from...
FIGURE 3. Analysis of IgM and anti-DNA serum levels of individual wt...
FIGURE 4. In vivo activation of wt and mutant B cells upon immunization...
FIGURE 5. In vitro stimulation and receptor down-modulation of...
B Cell Deletion, Anergy, and Receptor Editing in “Knock In” Mice Targeted with a Germline-Encoded or Somatically Mutated Anti-DNA Heavy Chain 1
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  • Dec 1998
To study the relative contributions of clonal deletion, clonal anergy, and receptor editing to tolerance induction in autoreactive B cells and their dependence on B cell receptor affinity, we have constructed "knock in" mice in which germline encoded or somatically mutated, rearranged anti-DNA heavy (H) chains were targeted to the H chain locus of...
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Citations

... It has been shown that anti-dsDNA B cells were suppressed by multiple tolerance mechanisms in mouse models (11)(12)(13)(14). Although some dsDNA-reactive B cells were deleted in bone marrow, many emigrated to the periphery and exhibited an altered surface phenotype and reduced lifespan (13,15,16). ...
Reference: Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice
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... This technique is used to further define defects in immune function and autoimmune development in lupus. [92][93][94] Knockout models of lupus The technique of gene knockout has been used extensively to study pathogenetic mechanisms in lupus. A large number of such knockout studies were performed on the MRL/lpr background and provided important understanding of the effects of certain genes and certain cells on disease. ...
Reference: Mouse models of lupus: What they tell us and what they don't
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