Diane Sekura Snyder's research while affiliated with University of Miami Miller School of Medicine and other places
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Publications (8)
Soft tissue x-ray techniques were used to measure skin thickness as influenced by the chronic usage of topical corticosteroids. In a double-blind study commercial preparations of 1% hydrocortisone (HC), 0.1% triamcinolone acetonide (TA), and a placebo cream were compared for their ability to produce atrophy in normal human forearm skin. After 8 wee...
Prostaglandin E (PGE) levels in the skin have been shown to be elevated during the 24 hr. period following exposure of guinea pig skin to ultraviolet radiation from 280-320 nm in the so-called UVB or "sunburn spectrum". The development of increased PGE levels paralleled the development of the delayed phase of erythema. When applied immediately afte...
Application of 5% para-aminobenzoic acid (PABA) to hairless mice one hour Prior to ultra-violet light (UVL) irradiation will almost totally protect these animals from developing tumors induced by chronic exposure to UVL in the 290 to 320 nm range in conjunction with a chemical carcinogen. Mice exposed to UVL and not protected by PABA developed prim...
Topical application of a 2.5 per cent indomethacin (IM) solution to the sunburned skin of humans and guinea pigs resulted in a marked decrease in ultraviolet light (UVL) -induced erythema. In humans, a decrease in skin temperatute and hyperalgesia to near normal levels was also observed. Epidermal responses to UVL injury such as keratinocyte cell d...
We have used intradermal injections of corticosteroids into normal and ultraviolet light (UVL)-induced inflamed human skin to evaluate the inherent atrophy producing potential as well as the vasoconstrictor potency of selected compounds. Two corticosteroids, desonide and triamcinolone acetonide, which differ only by the presence of a fluorine atom,...
Prostaglandins appear to be important mediators of ultraviolet erythema. It is reported that prostaglandin inhibitors, indomethacin and aspirin, injected intradermally, delay and decrease ultraviolet erythema. In this study the effects were evaluated of topically applied indomethacin and a corticosteroid on sunburn induced by a sunlamp or by natura...
Inhibitors of prostaglandin (PG) biosynthesis, indomethacin and aspirin, decrease and delay ultraviolet light-induced erythema when injected intradermally in humans and guinea pigs. Increasing amounts of inhibitor cause a more intense blanch with a longer duration demonstrating a dose response. Indomethacin was approximately 45 times more effective...
Citations
... It was established, that vitamins of B group, incl. РАВА and betacarotene (provitamin A) and D-alpha-tocopherol (vitamin E), possess the UV-absorbing property and are widely used to protect from solar radiation, photocarcinogenic exposures and inflammatory agents [1][2][3][4][5][6][7][8][9]. Molecular and genetic mechanisms of these processes in mammalian cells are poorly understood. ...
... [86] A double blinded crossover study, with 3.6 g of aspirin administered to sunburn patients over 9 h in three divided doses, 30 min prior to UVB exposure, along with a control placebo group revealed a significant reduction of erythema in the aspirin-treated group 4-6 h post-sun exposure. [87] Synder and Eaglstein [88] demonstrated the benefit of intradermal aspirin injections in patients prone to sunburn. Edwards et al. [89] have also highlighted the efficacy of oral aspirin in sunburn reactions. ...
Reference: Aspirin in dermatology: Revisited
... A number of experimental and clinical studies have been conducted to evaluate atrophogenicity of topical GCs. In the 70s, based on the X-ray technique for soft-tissue evaluation described by Black in 1969 [9], the first studies that measured GC-induced skin atrophy by a radiological method were performed [10][11][12][13]. Several noninvasive methods were then proposed for assessing the atrophogenic potential of GCs based on ultrasound techniques, using mainly highfrequency ultrasound, B-scan ultrasound and pulsed ultrasound [14][15][16][17]. ...
... Sunburn is an erythema reaction known to be induced by increased eicosanoids prostaglandin E 2 (PGE 2 ), and nitric oxide levels in the skin exposed to ultraviolet radiation [8][9][10][11][12][13]53]. Ultraviolet radiation stimulates epidermal keratinocytes to exhibit mRNA of cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS), which produce PGE 2 and NO, respectively. ...
... The UVB irradiation alone caused a decreased in HPT and an increased STHS up to 3 days after irradiation, confirming that UVB induces thermal hyperalgesia in the irradiated area (Hoffmann and Schmelz 1999;Bishop et al. 2009;Dawes et al. 2011;Weinkauf et al. 2013;O'Neill et al. 2015). The release of inflammatory mediators, subsequent to UVB irradiation, can sensitize TRPV1channels, inducing an axonal hyper excitability correlated with heat hyperalgesia (Snyder 1975;Wilgus et al. 2002;Kienzler et al. 2005;Sycha et al. 2005;Weinkauf et al. 2013;O'Neill et al. 2015). ...
... for the loss of collagen which accompanies intralesional steriod injection for treatment of keloids and hypertrophic scars [19]. ...
... Ein Nachweis für die Beteiligung von Prostaglandinen am Entzündungsvorgang nach UV-Bestrahlung ist die Hemmung der Erythementstehung durch ASS (Acetylsalicylsäure) [217] und Indomethacin [289], welche die Prostaglandin-Synthese hemmen. ASS und Indomethacin sind selektive Hemmer der Cyclooxygenase. ...
