Dhakshina M. Ganeshan's research while affiliated with University of Texas MD Anderson Cancer Center and other places

Publications (12)

Article
Full-text available
Background Single‐agent immune checkpoint inhibitors (ICIs) have demonstrated limited responses in recurrent ovarian cancer; however, 30%–40% of patients achieve stable disease. The primary objective was to estimate progression‐free survival (PFS) after sequential versus combination cytotoxic T‐lymphocyte antigen 4 and programmed death ligand 1 ICI...
Article
Full-text available
Anal cancer treatment response assessment can be challenging with both magnetic resonance imaging (MRI) and clinical evaluation considered essential. MRI, in particular, has shown to be useful for the assessment of treatment response, the detection of recurrent disease in follow up and surveillance, and the evaluation of possible post-treatment com...
Article
Patients often have symptoms due to the mass effect of a neoplasm on surrounding tissues or the development of distant metastases. However, some patients may present with clinical symptoms that are not attributable to direct tumor invasion. In particular, certain tumors may release substances such as hormones or cytokines or trigger an immune cross...
Article
Full-text available
Primary sclerosing cholangitis is a rare chronic inflammatory disease affecting the bile ducts, which can eventually result in bile duct strictures, cholestasis and cirrhosis. Patients are often asymptomatic but may present with clinical features of cholestasis. Imaging plays an important role in the diagnosis and management. This review covers the...
Article
Integrating diversity into healthcare systems has its challenges and advantages. Academic medicine strives to expand the diversity of the healthcare workforce. The Association of University Radiologists (AUR) put together a task force to review the concept of Diversity, Equity and Inclusion (DEI) as it pertains to Radiology and to propose strategie...
Article
Objectives: Response rates to immune checkpoint inhibitors (ICI) in recurrent ovarian cancer have been disappointingly low. While emerging data suggest increased activity in patients with ovarian clear cell carcinomas (OCCC), only a minority of patients benefit even among this group. The objective of the current study was to investigate correlates...
Article
Objectives Single agent immune checkpoint blockade (ICB) has demonstrated response rates of 5-15% in patients with recurrent high-grade ovarian cancer (HGOC), with another 15-40% of patients achieving stable disease. Combination ICB using ipilimumab and nivolumab resulted in improved response rates in a mixed population with platinum resistant and...
Article
Full-text available
Sex cord-stromal tumors of the ovary (SCST) are uncommon ovarian tumors arising from sex cord and/or stromal cells of the ovaries. They may be nonfunctional and asymptomatic or functional presenting with hyperestrogenic, hyperandrogenic or cushingoid symptoms. They present in a wide age group of women, mostly in early stages and follow a nonaggress...
Article
Full-text available
The perisplenic region is a complex anatomical area involving multiple peritoneal and subperitoneal structures, which influence the presentation and behavior of various pathologic processes. This review is a comprehensive resource for perisplenic anatomy and pathology with associated clinical presentations and imaging findings. Understanding the pa...
Article
Pneumoperitoneum can be an alarming radiological finding and a manifestation of a surgical emergency that warrant urgent intervention, or it can be a manifestation of chronic benign condition that can be managed conservatively. The sequela of misdiagnosing pneumoperitoneum due to surgical abdomen as a chronic benign pneumoperitoneum can be life-thr...
Article
Background Prostate MRI is used widely in clinical care for guiding tissue sampling, active surveillance, and staging. The Prostate Imaging Reporting and Data System (PI-RADS) helps provide a standardized probabilistic approach for identifying clinically significant prostate cancer. Despite widespread use, the variability in performance of prostate...
Article
AIM To assess the ability of dual-energy computed tomography (DECT) to distinguish benign from malignant ovarian tumours (OTs). MATERIALS AND METHODS Following approval of the institutional review board, the institutional database was mined for treatment-naive patients who underwent primary cytoreduction for OT. Thirty-seven patients were included...

Citations

... In terms of mode of administration, it is difficult for this review to determine adherence to the recommendation for electronic methods. The majority of studies included neglected to report on the mode of administration of instruments; only ten studies [35,46,[58][59][60][61][62][63][64][65] reported using electronic administration. In fact, only two studies [35,46] included in this review met all the recommendations outlined by Basch et al. [30] for the collection and reporting of PRAE data. ...
... As for the 531 abstracts obtained through strategy 4, we found 5 relevant abstracts that mentioned the following as targets for being empowered: underrepresented minority leadership [335], individuals change agents [349], people discussing EDI in libraries [350], DEI in radiology [351], and students [319]. ...
... In a recent retrospective analysis of ovarian clear cell carcinoma [23], the authors investigated whether specific mutations, including those in PP2A, were associated with survival outcomes following ICB therapy. ...
... PSC is difficult to diagnose, and no specific biomarker that could support the diagnosis of PSC has been identified [10,57]. Liver function tests may be useful to start an investigation, but there are no specific laboratory markers that help diagnose PSC [58]. Although patients with PSC may be initially assessed with ultrasound or computed tomography, cholangiography based on magnetic resonance cholangiography or endoscopic retrograde cholangiopancreatography evaluation is usually required to make a definitive diagnosis. ...
... The combination of nivolumab and the anti-CTL-4 tremelimumab, as sequential versus concomitant administration, in platinum-resistant heavily pretreated patients with HGSOC, did not show signs of activity, having reported no objective response and limited PFS [56]. ...
... early-stage SCSTs typically undergo conservative surgery to preserve fertility or maintain ovarian function, whereas patients with EOC require radical tumor resection followed by adjuvant chemotherapy [2,5]. It is therefore imperative to distinguish between SCST and EOC at the preoperative stage [6]. ...
... The pathogenesis of PCI is still uncertain, and there are 4 main theories that could explain its origin: 1) bacterial -the presence of gas-producing bacteria inside the intestinal wall; 2) mechanical -increased intraluminal pressure or epithelial injury allowing gas passage from the lumen into the intestinal wall; 3) biochemical -increased hydrogen gas production from carbohydrate fermentation exerts pressure within the intestinal lumen and is forced through the mucosa; 4) pulmonary diseases such as COPD and interstitial pneumonia may cause alveolar rupture leading to gas release, which travels along the mesenteric vessels into the mesentery. Coughing with abrupt changes in intra-abdominal pressure may also be an important contributing factor 2, 3,5,7,9,[11][12][13]15,[19][20][21]26,[28][29][30] . ...
... With repetition, pertinent images may be memorized and patterns recognized, but this type of learning, divorced from anatomical understanding, can be limiting. The perisplenic region can be a particularly confusing area in which to recognize pathology with its complex peritoneal spaces and folds [4]. The pericardial space, coined the "living" pericardial space by electrophysiologists for its nuanced anatomy, can be another challenge for the student of the FAST exam [5]. ...
... Similarly, a large multicentre study of 3449 men with suspected or biopsy confirmed untreated prostate cancer across 23 centres comprising the Society of Abdominal Radiology Prostate Cancer Disease-Focused Panel, found a positive predictive value (PPV) for clinically significant cancer (Gleason Grade Group ≥2) to range from 5%, 15%, 39%, and 72% for PI-RADS v2 scores of 2, 3, 4, and 5, respectively [22]. The PPV varied widely across the different imaging centres, with an estimated overall PPV for PI-RADS score ≥3 of 35% with an interquartile range of 27-48% across sites. ...
... Notably, recent advancements have highlighted its significant advantages in the evaluation of oncology patients [20][21][22]. Key among these applications are virtual noncontrast (VNC) and iodine maps, which effectively highlight tissue vascularity [23][24][25][26][27][28][29][30][31][32][33][34] in both primary tumors and metastases [35][36][37][38][39][40][41][42][43]. Furthermore, enhanced visualization of vascular structures enables the optimized assessment of vascular involvement [44]. ...