David J. Aziz's research while affiliated with The University of Arizona and other places
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Publications (6)
The use of reflected light confocal microscopy is proposed to rapidly observe unfixed, unstained biopsy specimens of human skin. Reflected light laser scanning confocal microscopy was used to compare a freshly excised, unfixed, unstained biopsy specimen, and in vivo human skin. Optical sections from the ex vivo biopsy specimen of human skin and in...
The imaging performance of a confocal microscope including a fiber-optic imaging bundle is discussed. The goal of such a system is to examine objects which would otherwise be prohibited to confocal microscopy. It is found that this system can produce images comparable to that of a commercial confocal microscope.
The design of a confocal microscope including a fiber-optic imaging bundle is discussed, and experimental results are presented. The imaging bundle extends the range of the confocal microscope to image samples inaccessible to a conventional confocal system. The main advantage of this design over the single-fiber confocal microscope is the simplifie...
The concept for a new type of confocal microscope with a fiber-optic imaging bundle is presented, and experimental results are shown to demonstrate the principle. The primary advantage of the system is the flexibility of imaging samples that would otherwise be inaccessible to confocal microscopy.
Fluorescence response of canine heart tissue is studied in an attempt to localize the conduction system atrioventricular (AV) node. Data is collected for 364 nm and 308 nm illumination via a 750 micrometers diameter fiber placed against the tissue. This is done for sample locations in the right atrium, AV ring, and right ventricle, and for a rectil...
Citations
... While miniaturized scanning systems suitable for endoscopy have been widely demonstrated (see for example [2,3]), a simpler solution is to scan a laser over the proximal end of a fiber bundle outside of the patient, and thus have the scanning pattern transferred to the tissue without any need for physical scanning at the distal tip of the probe. Confocal microscopy through fiber bundles was demonstrated by Gmitro and Aziz in 1993 [4], and has been explored extensively since, particularly using the Cellvizio endomicroscope from Mauna Kea Technologies [5]. Confocal fluorescence endomicroscopy has been investigated for a wide range of clinical applications, particularly in the gastrointestinal tract [6], using both intravenous fluorescein and topical fluorescent stains. ...
... Several systems applied ultraviolet light for excitation of fluorophores intrinsic in the tissue and measurement of spectra of the fluorescent light emission. [37][38][39][40] Optical fibers coupled the tip of the spectroscopic probe to the light sources and detectors. The systems were evaluated using canine hearts as well as fresh and fixed samples from human hearts. ...
... 53 Furthermore, it is readily used for microscopy of unstained tissue samples. 54,55 In previous studies, Mueller matrix polarimetry has been combined with a confocal imaging system to obtain 3-D polarization information for collagenous tissues. 21,44 However, confocal microscopy has no inherent imaging specificity to collagen, and hence, any subsequent analysis based on acquired images cannot discriminate between collagenous and noncollagenous regions. ...
... Optical fibre bundles, also known as multicore fibres (MCFs), have ushered in a new era of deep tissue imaging, furnishing valuable diagnostic information [5,48,56,57]. These MCFs feature a high-density array layout within an overall bundle diameter of less than 1 mm. ...
