D Modesti's research while affiliated with Istituto Superiore di Sanità and other places
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Publications (9)
On the basis of the results obtained with pilot studies conducted in vitro on human low density lipoprotein (LDL) and on cell cultures (Caco-2), which had indicated the ability of certain molecules present in olive oil to inhibit prooxidative processes, an in vivo study was made of laboratory rabbits fed special diets. Three different diets were pr...
Experimental and clinical evidence suggest that oxidative stress causes cellular damage, leading to functional alterations of the tissue. Free radicals may thus play an important role in the pathogenesis of a number of human diseases. Among pro-oxidant agents, oxidized LDL lead to the production of cytotoxic reactive species, e.g., lipoperoxides, c...
Olive oil contains several phenolic compounds with antioxidant activity, whose levels depend strongly on the kind of cultivar grown, fruit ripening effects and the oil extraction process. Therefore, the beneficial effects exerted by olive oil consumption on the resistance of low density lipoproteins (LDLs) to oxidation depend not only on an increas...
Successful aging, characterized by little or no loss in physiological functions, should be the usual aging process in centenarians. It is known that well-preserved physiological functions depend on the proper functioning of cell systems. In this article we focus on cell membrane integrity and study the red blood cell membrane to evaluate the effect...
Virgin olive oil stability to autoxidation is mainly due to phenolic compounds naturally occurring in it, but contrasting data have been published on the effectiveness of the same antioxidant compounds. With thermogravimetric analysis (TGA) it is possible to have an estimation of oil resistance to oxidation, having a measure of weight gain percent...
Recent reports on the antioxidant activity of hypotaurine indicate that it behaves as a hydroxyl radical scavenger7. In vitro experiments have shown excellent reactivity with ·OH and HOCl based on rate constants calculated for these reactions2. Cystamine-α-disulfone has been proposed as a product of the radical reaction12, as demonstrated by the is...
Background. Yoshida rats are characterized by spontaneous hypercholesterolemia and hypertriglyceridemia. Moreover, they show age-related variations in plasma and liver lipid content similar, but earlier, than those of normolipidemic rats. On the other hand, it is known that dietary fats and cholesterol may affect lipid metabolism. This suggested us...
Lipoprotein and liver lipids of spontaneously hyperlipidemic Yoshida rats were compared with those of normolipidemic Wistar animals for studying their age- and strain-related differences. Both strains showed an age-related increase in the total plasma cholesterol concentration. However, the Yoshida strain had a higher content of cholesteryl esters...
Background. Humans and some animal species show age-related changes in cholesterol distribution that are evidenced by an increase in plasma cholesterol levels. Specifically in male Wistar rats the age-dependent plasma cholesterol increase is correlated with changes in both the distribution of HDL and the storage of cholesterol inside the liver. On...
Citations
... In terms of total mass loss in the fat degradation stages, all samples added with antioxidants performed better than the control, showing total loss percentages of 22.99, 18.22, and 21.05% for BHA, mixed tocopherols, and grape seed extract, respectively. In addition, Gennaro et al. (1998) and Marinho (2012) explained that the higher the temperatures at the onset of thermal decomposition, the longer the predicted lifetimes of the samples. The curves obtained in the thermogravimetric analyses allow the identification of the initial temperatures of degradation of the fats, which were 238, 250, 285, and 250 °C for the control samples, with the addition of BHA, the mixture of tocopherols and grape seed extract, respectively. ...
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... The observed difference may be attributed to the differences in the strain of rats; Grinna used Sprague-Dawley rats for these studies. Strain-dependent variations in the age-related changes in lipid profiles of plasma and liver lipids of Yoshida and Wistar rats have been reported (Masella et al., 1995). The phospholipid profiles of the mitochondria from the two tissues also changed in a tissue-specific manner (Tables 3 and 4). ...
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... Despite these plausible biological mechanisms, the role of PUFA on cognitive outcomes such as cognitive decline and dementia is largely unknown, particularly later in life. Notably, higher cellular membrane levels of PUFA has been identified among healthy centenarians [7], supporting a possible role of these fatty acids on membrane integrity and fluidity that could relate to healthy cognitive aging. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/386549586907137-1469172011401_Q64/Patrizia-Caprari-2.jpg)
... Tyrosol, which is also known as 2-(4-hydroxyphenyl)ethanol, belongs to the phenylethanoids category and exhibits notable cellular antioxidant properties [59]. In fact, it has demonstrated the ability to protect Caco-2 intestinal mucosa from the harmful cytotoxic and apoptotic effects induced by oxidized LDL [60]. Moreover, hydroxytyrosol, also known as 4-(2-hydroxyethyl)-1,2-benzendiol, stands out as an exceptionally potent antioxidant compound within the phenolic compounds derived from the olive tree. ...
... Low-density lipoprotein (LDL) oxidation plays a critical role in the development of atherosclerosis and coronary heart disease. Various in vitro and in vivo studies have shown that the polyphenolic compounds of EVOO play an important role in the prevention of atherosclerotic damage through their inhibition of LDL oxidation [42][43][44][45]. ...
... The antioxidants reduce the risk of chronic diseases [5,6], lower inflammation, and protect blood cholesterol from oxidation. The latter two benefits may lower the risk of heart diseases in several ways [7,8]. For example, olive oil improves blood vessels' flow, helping prevent excessive blood clotting. ...
