D. C. Rao's research while affiliated with Yale-New Haven Hospital and other places
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Publications (2)
Recent linkage findings for psychiatric disorders, in particular schizophrenia, manic-depression, and Alzheimer disease, have raised a number of important conceptual issues regarding the genetic etiology of these diseases, as well as the appropriate interpretation of linkage results in studying complex diseases. Perspectives on mode of inheritance,...
A two-parameter (admixture) test (Lod2) for the detection of linkage which allows for heterogeneity is described. Lod score values for this test which lead to comparable type 1 error probabilities as the conventional (homogeneous) single-parameter lod score test (Lod1) are derived. For example, a Lod2 value of 3.70 corresponds to the conventional l...
Citations
... This disease locus is presumed to lie at some map position x relative to the marker loci. The hypothesis of linkage with admixture due to locus heterogeneity assumes that a certain proportion, α, of families have disease due to the actions of a locus at this position whereas (1 − α) families manifest the effects of a locus with the same disease model parameters but at an unlinked position (Risch, 1989). The null hypothesis of no linkage assumes α = 0. ...
... Both family and adoption studies have suggested that several genetic loci are involved in the genesis of SCZ [59]. Linkage analyses of schizophrenic genes that have been performed on chromosomes 2q [60], 3p [61], 4p [62], 5q [63] , and 22q [64,65] around the world whereas the first study from Pakistan performed haplotype and linkage disequilibrium analysis association of DISC locus (1q24.1) ...
