Cortlandt M. Sellers's research while affiliated with Baylor College of Medicine and other places

... The incidence of HCC after DAA administration and its biological behavior is also expected to impact survival. SVR reduced the risk of five-year all-cause and liverspecific mortality (Dang et al., 2020) and provided higher OS rates (Kamp et al., 2019;Kamp et al., 2020;Ochi et al., 2021). Kamp (2019) (2021) showed much more aggressive tumor behavior in DAA patients. ...

... Global estimates indicate that 71 million people suffer from hepatopathies caused by chronic hepatitis C virus (HCV) infection. The prognosis and disease progression have significantly improved due to the availability of Direct-acting antiviral (DAA) therapy [1,2]. The global accessibility of DAA treatment and the simplification of therapeutic strategies have made it possible to eliminate HCV by improving screening methods, identifying infected individuals with active infection, and initiating timely treatment. ...

... Case volume and type of hospital have also been shown to affect survival rates. Hospitals with a high volume of HCC cases and academic hospital settings are correlated with im- proved overall survival, probably due to the higher-experienced providers, better interdisciplinary team integration, and overall improved logistics [67]. The specific impact of a multidisciplinary approach in patients with HCC has also been found to have a positive effect on overall survival compared with patients not managed in a multidisciplinary manner, with 5-year survival rates of 71.2% and 49.4%, respectively [29]. ...

... Also, the deprivation component taking into account all the conventional deprivation aspects besides living in a single-parent family resulted in a potential risk factor for HCC survival. This is in line with previous studies on socioeconomic status and HCC survival [44,45]. ...

... Changes in pro-inflammatory and anti-inflammatory cytokine levels, i.e., interleukin 2 (IL2), IL4, IL6, IL10, IL17A, interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α), are observed in iCCA patients [4,5], which could serve as potential iCCA diagnostic markers. In addition, peripheral blood index, e.g., neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and systemic-immune inflammation index (SIII), are considered potential prognostic factors for assessing clinical outcomes in iCCA patients [6][7][8]. The diagnostic utility of these markers is, however, limited. ...

... Surgical resection remains the only potentially curative treatment (3). However, the recurrence rate after surgery is at 50%-70% (4,5) and is directly related to a poor 5-year survival rate of 4%-35% (6). Adjuvant systemic treatments, such as capecitabine, have been reported to lower the recurrence rates and improve prognostic outcomes in patients with biliary tract cancer following radical resection; capecitabine has not been universally accepted as a novel standard of care because it failed to meet its primary endpoint of improving the overall survival (OS) in the intention-to-treat population. ...

... Surgical treatment has a higher incidence of adverse reactions, longer hospital stay and higher cost, whereas ablation has a higher recurrence rate. However, the higher recurrence rate of ablation does not affect OS [60,61]. ...

... DPV practices and preferences vary throughout the world, the main operative methods for DPV include splenectomy and portosystemic shunt and particular radiological DPV. DPV has become a frequently-used bridging therapy for LT [10][11][12][13][14]. ...