Cheng Cheng's research while affiliated with First Affiliated Hospital of China Medical University and other places
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Publications (5)
The present study was designed to investigate whether 17β-estrogen (E2) reduces myocardial I/R injury by inhibiting NLRP3 inflammasome mediated pyroptosis. In vivo , four-weeks-old female C57BL/6 mice underwent ovariectomy (Ovx) before E2 replacement therapy. After the establishment of myocardial I/R injury, plasma E2, LDH and CK-MB were detected,...
Objectives:
To investigate the procedural efficiency, efficacy, and safety of high-power, short-term radiofrequency ablation delivered by the SmartTouch Surround Flow (STSF) catheter for paroxysmal atrial fibrillation (AF).
Methods:
We retrospectively analyzed a total of 72 patients who were admitted with paroxysmal AF, and who underwent radiofr...
Objectives:
This study aimed to prospectively observe the changes in the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) before and after percutaneous coronary intervention (PCI) and their impact on the prognosis of patients with acute coronary syndrome (ACS).
Methods:
Blood samples from 205 patients with ACS were col...
Background
The NOD–like receptor pyrin domain–containing protein 3 (NLRP3) inflammasome activation–mediated pyroptosis pathway has been linked to myocardial ischemia–reperfusion (MI/R) injury. This study explored whether uric acid (UA) aggravates MI/R injury through NLRP3 inflammasome–mediated pyroptosis.
Methods
In vivo, a mouse MI/R model was es...
Citations
... We will measure the cardiac biomarkers to monitor the status of AMI (60). We will assess inflammatory biomarkers such as leukocytes, neutrophils, lymphocytes, and Hs-CRP, which are linked with SF-NR and are predictors of adverse cardiac events in the patients that have undergone PCI (61)(62)(63). Patient pain levels will be quantified using the NRS Chest Pain Scale, an internationally recognized method. Since long-term pain has significant emotional impact (64, 65), we will also use the VAS-A scale to determine if acupuncture alleviates or decreases emotional disorders in patients with AMI (66). ...
... Previous research has indicated that hyperoxic conditions inhibit XOR enzyme activity, whereas hypoxia promotes XOR expression [90] (Figure 4). This observation aligns with experimental findings demonstrating a larger area of cardiac infarction in the HUA group within the mouse model of MIRI [91]. Therefore, the activity of XOR plays a pivotal role in the ability of HUA to induce oxidative damage to cardiomyocytes, indicating that XOR is a promising therapeutic target for subsequent cardiac disorders. ...
